2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Heme Oxygenase (HO)

Heme Oxygenase (HO)

Heme Oxygenase

Heme oxygenase (HO) is an enzyme that catalyzes the degradation of heme to produce biliverdin/bilirubin, ferrous iron and carbon monoxide. Heme oxygenase (HO) can be divided into inducible type (HO-1) and constitutive type (HO-2). HO-1 is a kind of heat shock protein 32 (HSP32). Its expression level is low in normal physiological state, but it will increase significantly when induced by various stimuli such as oxidative stress, heavy metals, and inflammatory factors. HO-2 is continuously and stably expressed in brain, testis and other tissues, and is involved in maintaining the normal physiological function of cells. Heme oxygenase (HO) plays a key role in cell stress response and homeostasis, and the dysregulation of its expression or activity is related to the pathophysiology of cardiovascular disease, diabetes, obesity, lung disease, gastrointestinal disease, renal dysfunction, dermatitis, cancer and other diseases[1].

Heme Oxygenase (HO) Isoform Specific Products:

Heme Oxygenase (HO) Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-162857
    Heme Oxygenase-1-IN-3
    		Inhibitor
    Heme Oxygenase-1-IN-3 (compound 4) is a highly selective heme oxygenase-1 (HO-1) inhibitor (Kd=141 nM) that can be used in the research of cancer and neurodegenerative diseases.
    Heme Oxygenase-1-IN-3
  • HY-170867
    Nrf2/HO-1 activator 3
    		Inhibitor
    Nrf2/HO-1 activator 3 (Compound C3a) is the activator for Nrf2 signaling pathway that promotes the Nrf2 translocation into nuclei and upregulates the expression of heme oxygenase-1 HO-1. Nrf2/HO-1 activator 3 inhibits the overespression of ROS and MDA in H2O2- or glucose-stimulated H9c2 cardiomyocytes, inhibits the cell viability and colony formation, thereby exhibiting antioxidant efficacy.
    Nrf2/HO-1 activator 3
  • HY-W010320R
    Ethyl maltol (Standard)
    Ethyl maltol (Standard) is the analytical standard of Ethyl maltol. This product is intended for research and analytical applications. Ethyl maltol (2-Ethyl-3-hydroxy-4H-pyran-4-one) is an orally active and important food additive and flavor enhancer. Ethyl maltol is less toxic to rats and dogs. Ethyl maltol can enhance copper-mediated cytotoxicity and induce apoptosis in lung epithelial cells.
    Ethyl maltol (Standard)
  • HY-N0576R
    Solanesol (Standard)
    		Inducer
    Solanesol (Standard) is the analytical standard of Solanesol (HY-N0576). This product is intended for research and analytical applications. Solanesol is an orally active aliphatic terpene alcohol. Solanesol is mainly found in tobacco and other Solanaceae plants. Solanesol induces HO-1 and Hsp70 expression, activates p38 and Akt signaling pathways, and inhibits Apoptosis (reduces caspase-3 and PARP cleavage). Solanesol has antioxidant, anti-inflammatory, and neuroprotective activities. Solanesol can be used in the research of Huntington's disease, alcoholic liver disease, chronic inflammatory pain, anxiety, Alzheimer's disease, and bipolar disorder.
    Solanesol (Standard)
  • HY-N1500S1
    Pulegone-d8
    		Activator
    Pulegone-d8 is deuterated labeled Pulegone (HY-N1500). Pulegone is a monoterpene ketone compound widely present in the essential oils of many plants. Pulegone can also be used as a bird repellent. Pulegone has multiple activities such as anti-inflammatory, antibacterial, antifungal, and anti-hyperalgesic effects. Pulegone is particularly effective against bacteria of the Salmonella species.
    Pulegone-d<sub>8</sub>
  • HY-N0648R
    Monotropein (Standard)
    		Activator
    Monotropein (Standard) is the analytical standard of Monotropein. This product is intended for research and analytical applications. Monotropein is an iridoid glycoside that can be isolated from the roots of Morinda officinalis. Monotropein inhibits the expression of inflammatory mediators in dextran sulfate sodium (DSS)-induced colitis mouse model. Monotropein exerts protective effects against IL-1β-induced apoptosis and catabolic responses on osteoarthritis chondrocytes. Monotropein has cartilage protective activity. Monotropein can alleviate Cisplatin (HY-17394)-induced acute kidney injury by inhibiting oxidative damage, inflammation and apoptosis through activation of Nrf2/HO-1 pathway and inhibition of NF-κB signaling. Monotropein can be studied in research for osteoarthritis, acute kidney injury and acute lung injury.
    Monotropein (Standard)
  • HY-N0257R
    Epimedin A (Standard)
    		Activator
    Epimedin A (Standard) is the analytical standard of Epimedin A (HY-N0257). This product is intended for research and analytical applications. Epimedin A, one of the main flavonoid active components in Herba Epimedii, is orally active. Epimedin A can inhibit osteoclastogenesis, differentiation, and bone resorption. Epimedin A also possesses anti-inflammatory activity. Epimedin A can be used in the research of osteoporosis and inflammatory diseases.
    Epimedin A (Standard)
  • HY-N1500R
    Pulegone (Standard)
    		Activator
    Pulegone (Standard) is the analytical standard of Pulegone (HY-N1500). This product is intended for research and analytical applications. Pulegone is a monoterpene ketone compound widely present in the essential oils of many plants. Pulegone can also be used as a bird repellent. Pulegone has multiple activities such as anti-inflammatory, antibacterial, antifungal, and anti-hyperalgesic effects. Pulegone is particularly effective against bacteria of the Salmonella species.
    Pulegone (Standard)
  • HY-W854721
    Mn(III) Protoporphyrin IX chloride
    		Inducer
    Mn(III) protoporphyrin IX chloride is a metalloporphyrin. It induces mRNA expression of the genes encoding δ-aminolevulinate synthase and heme oxygenase (HO), enzymes that catalyze the rate-limiting steps of heme biosynthesis and degradation, respectively, in chick embryo liver cells when used at a concentration of 10 μM. Mn(III) protoporphyrin IX chloride-containing nanobialys have been used in magnetic resonance imaging (MRI) of fibrin clots in vitro. It has also been used in the synthesis of Mn(III) protoporphyrin IX-6(7)-glycyl-glycyl-L-histidine methyl ester (MnGGH), a metalloporphyrin conjugate with microperoxidase activity.
    Mn(III) Protoporphyrin IX chloride
  • HY-N0310R
    Soyasaponin Bb (Standard)
    		Inducer
    Soyasaponin Bb (Standard) is the analytical standard of Soyasaponin Bb (HY-N0310). This product is intended for research and analytical applications. Soyasaponin Bb is an orally active, covalent inducer of heme oxygenase HO-1 and an inhibitor of aldose reductase AKR1B1. Soyasaponin Bb can regulate oxidative stress pathways, enhance antioxidant capacity, reduce reactive oxygen species (ROS) generation, and inhibit lipid peroxidation and hepatocyte apoptosis. Soyasaponin Bb improves alcohol-induced hepatocyte membrane damage and liver function abnormalities, and improves Scopolamine (HY-N0296)-induced memory impairment. Soyasaponin Bb has antioxidant, hepatoprotective, and neuroprotective activities.
    Soyasaponin Bb (Standard)
Heme Oxygenase (HO) Isoform Comparison

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