Ferrochelatase

Ferrochelatase is a key enzyme involved in heme biosynthesis. Ferrochelatase can catalyze the binding of ferrous ions to protoporphyrin IX to form heme. In the heme synthesis pathway, Ferrochelatase is involved in the last crucial reaction, ensuring the normal synthesis of heme in organisms. This provides a material basis for the functions of heme-containing proteins such as hemoglobin and myoglobin, thus guaranteeing the smooth progress of important physiological processes such as oxygen transport and cellular respiration. Abnormalities in Ferrochelatase activity are closely related to diseases such as hereditary erythropoietic protoporphyria^[1].

References:

[1]. Ferreira GC. Ferrochelatase. Int J Biochem Cell Biol. 1999 Oct;31(10):995-1000. [Content Brief]

Ferrochelatase Inhibitors (4)

Ferrochelatase Related Products (4):

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-114758

Pyridoxal isonicotinoyl hydrazone	Inhibitor	99.96%
Pyridoxal isonicotinoyl hydrazone is an orally active and lipophilic iron-specific chelator that acts as a non-competitive inhibitor of ferrochelatase (FECH) by binding iron ions. Pyridoxal isonicotinoyl hydrazone disrupts heme biosynthesis, leading to reduced FECH stability and increased protoporphyrin IX (PPIX) accumulation. Pyridoxal isonicotinoyl hydrazone is promising for research of iron-overload diseases (e.g., β-thalassemia).

HY-129430

N-Methylprotoporphyrin IX	Inhibitor	≥99.0%
N-Methylprotoporphyrin IX is a potent inhibitor of ferrochelatase enzyme.

HY-118594

Diethyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate	Inhibitor	99.79%
Diethyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate is a ferrochelatase inhibitor that blocks heme synthesis. Diethyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate induces Mallory Denk bodies (MDB) formation. Diethyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate can be used in the fields of iron metabolism, oxidative stress, and liver-related diseases.

HY-136476C

Ni(II) protoporphyrin IX	Inhibitor
Ni(II) protoporphyrin IX is a metalloporphyrin that has a low tendency toward axial ligation, becomes distorted when bound to ferrochelatase.

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