2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Ferrochelatase
  5. Ferrochelatase Inhibitor

Ferrochelatase Inhibitor

Ferrochelatase Inhibitors (5):

Cat. No. Product Name Effect Purity
  • HY-114758
    Pyridoxal isonicotinoyl hydrazone
    		Inhibitor 99.96%
    Pyridoxal isonicotinoyl hydrazone is an orally active and lipophilic iron-specific chelator that acts as a non-competitive inhibitor of ferrochelatase (FECH) by binding iron ions. Pyridoxal isonicotinoyl hydrazone disrupts heme biosynthesis, leading to reduced FECH stability and increased protoporphyrin IX (PPIX) accumulation. Pyridoxal isonicotinoyl hydrazone is promising for research of iron-overload diseases (e.g., β-thalassemia).
  • HY-129430
    N-Methylprotoporphyrin IX
    		Inhibitor ≥99.0%
    N-Methylprotoporphyrin IX is a potent inhibitor of ferrochelatase enzyme.
  • HY-118594
    Diethyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate
    		Inhibitor 99.79%
    Diethyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate is a ferrochelatase inhibitor that blocks heme synthesis. Diethyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate induces Mallory Denk bodies (MDB) formation. Diethyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate can be used in the fields of iron metabolism, oxidative stress, and liver-related diseases.
  • HY-136476C
    Ni(II) protoporphyrin IX
    		Inhibitor
    Ni(II) protoporphyrin IX is a metalloporphyrin that has a low tendency toward axial ligation, becomes distorted when bound to ferrochelatase.
  • HY-118594R
    Diethyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate (Standard)
    		Inhibitor
    Diethyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate (Standard) is the analytical standard of Diethyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate. This product is intended for research and analytical applications. Diethyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate is a ferrochelatase inhibitor that blocks heme synthesis. Diethyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate induces Mallory Denk bodies (MDB) formation. Diethyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate can be used in the fields of iron metabolism, oxidative stress, and liver-related diseases.