2. Signaling Pathways
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  4. Drug Derivative

Drug Derivative

Drug derivative

Drug derivatives are derived from parent compounds. They replace or add atoms and groups through chemical reactions to optimize the various properties of the parent compound and reduce side effects. The application of drug derivatives provides a diverse compound library for drug research and development and accelerates the discovery of new drugs. For example, urea derivatives Glibenclamide can prolong the blood sugar-lowering effect of anti-diabetic drugs.

Drug Derivative Related Products (1529):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W010562
    2-Methoxypyrazine
    		99.98%
    2-Methoxypyrazine is an active compound. 2-Methoxypyrazine can be used for the research of various biochemical studies.
    2-Methoxypyrazine
  • HY-170472
    Bpin-Bedaquiline
    Bpin-Bedaquiline (compound 2) is a boronic ester precursor of Bedaquiline (HY-14881). Bpin-Bedaquiline can react with H476Br to synthesize 76Br-Bedaquiline.
    Bpin-Bedaquiline
  • HY-I0180A
    Ticagrelor EP Impurity E hydrochloride
    		Control 99.96%
    Ticagrelor EP Impurity E hydrochloride is a conformationally restricted phenethylamine.
    Ticagrelor EP Impurity E hydrochloride
  • HY-114531
    Lomifylline
    		99.67%
    Lomifylline is a derivative of Xanthine (HY-W017389). Lomifylline can be used in research of sepsis and septic or endotoxic shock, when combined with an antibody to TNF or a TNF binding fragment.
    Lomifylline
  • HY-124479A
    γ-Lumicolchicine
    		99.70%
    γ-Lumicolchicine is an inactive analogue of Colchicine (HY-16569) that can be used as an experimental control for Colchicine action.
    γ-Lumicolchicine
  • HY-113490
    15-KETE
    		≥99.0%
    15-KETE (15-KETE) is produced by oxidation of the 15-hydroxyl of 15-HETE.
    15-KETE
  • HY-W585922
    3β-Cholic acid
    		99.7%
    3β-Cholic acid is a derivative of cholic acid (HY-N0324), and can be found in human feces.
    3β-Cholic acid
  • HY-125938
    Cycloartenyl ferulate
    		98.98%
    Cycloartenyl ferulate (Cycloartenol ferulate; Cycloartenol ferulic acid ester) is a derivative of γ-oryzanol (HY-B2194) with multiple biological activities including antioxidant, anti-inflammatory, and anti-tumor properties. Cycloartenyl ferulate selectively binds to IFNγR1 (binding affinity Kd = 0.5 μM) to activate the canonical JAK1/2-STAT1 signaling pathway. Cycloartenyl ferulate inhibits paraquat (PQ)-triggered apoptosis and ROS in HK2 cells. Cycloartenyl ferulate enhances the activation and cytolytic activity of natural killer (NK) cells by upregulating the expression of NK cell activation receptors (NKG2D, NKp30, NKp44) and the release of cytotoxic molecules and cytokine IFNγ. Cycloartenyl ferulate exerts anti-cancer effects in tumor mice models. Cycloartenyl ferulate can be used for the study of cancer and allergic inflammation intervention.
    Cycloartenyl ferulate
  • HY-W279223
    Potassium tetrakis(4-chlorophenyl)borate
    		≥98.0%
    Potassium tetrakis(4-chlorophenyl)borate is an active compound.
    Potassium tetrakis(4-chlorophenyl)borate
  • HY-105946A
    Hidrosmin (mixture)
    Hidrosmin (mixture) is a mixture of 3,5-di-O-(hydroxyethyl)diosmin and 3'-mono-O-(hydroxyethyl)diosmin.
    Hidrosmin (mixture)
  • HY-101595
    RPH-2823
    		≥99.0%
    RPH-2823, a basic triamterene derivative, induces a dose-dependent decrease in short-circuit current (SCC) and increase in transepithelial electrical resistance.
    RPH-2823
  • HY-19714
    XY1
    		99.10%
    XY1 is an analog of SGC707 (HY-19715), a potent and selective PRMT3 inhibitor with an IC50 of 31 nM. XY1 is completely inactive against PRMT3. XY1 and SGC707 represent an excellent pair of tools for further elucidating the biological functions and disease relevance of PRMT3.
    XY1
  • HY-145554
    Bafrekalant
    		99.67%
    Bafrekalant is a diazabicyclic substituted imidazo[l,2-a]pyrimidine-derivative. Bafrekalant has the potential for the research of breathing disorders, including sleep-related breathing disorders such as obstructive and central sleep apnea and snoring (extracted from patent WO2018228907A1).
    Bafrekalant
  • HY-B1714
    NSC 601980 analog
    		98.0%
    NSC 601980 analog is an analogue of NSC601980. In yeast screening experiments, NSC 601980 exhibited antitumor activity, effectively inhibiting cell proliferation in both COLO 205 and HT29 cell lines, with Log GI 50 values of -6.6 and -6.9, respectively.
    NSC 601980 analog
  • HY-76665
    Anticancer agent 209
    		≥99.0%
    Anticancer agent 209 (compound 1) is an anticancer agent. Anticancer agent 209 exhibits cytotoxic activity against colon cancer in vitro.
    Anticancer agent 209
  • HY-101556
    Namirotene
    		99.33%
    Namirotene (CBS-211A) is a retinoic acid analog, which is utilized in topical eye administration. Namirotene enhances 1α,25-dihydroxyvitamin D3-induced cytotoxicity in cell U937 and induces the differentation in U937.
    Namirotene
  • HY-123358
    AR-H049020XX
    AR-H049020XX is an active compound.
    AR-H049020XX
  • HY-136554
    WYC-210
    		99.18%
    WYC-210, a Tazarotene derivative, is a retinoid compound with lower anticancer activity. WYC-210 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    WYC-210
  • HY-173374
    DOTAGA-FAP-2286-ALB
    DOTAGA-FAP-2286-ALB is a derivative of Rofapitide tetraxetan (HY-147057). DOTAGA-FAP-2286-ALB is a selective fibroblast activation protein (FAP) inhibitor with an IC50 value of 67.5 nM. DOTAGA-FAP-2286-ALB enhances tumor retention via albumin interaction, prolonging blood circulation and improving radiometal complex stability (e.g., with 111In and 225Ac). DOTAGA-FAP-2286-ALB is promising for research of radionuclide therapy (TRT) of FAP-positive solid tumors.
    DOTAGA-FAP-2286-ALB
  • HY-121469
    Dioxone
    		≥98.0%
    Dioxone is a substance possessing convulsant properties qualitatively similar to leptazol and bemegride. Dioxone is orally active.
    Dioxone