2. Signaling Pathways
  3. Immunology/Inflammation
  4. CD3

CD3

Cluster of differentiation 3

CD3 (cluster of differentiation 3) is a protein complex and T cell co-receptor that is involved in activating both the cytotoxic T cell (CD8+ naive T cells) and T helper cells (CD4+ naive T cells). It is composed of four distinct chains. In mammals, the complex contains a CD3γ chain, a CD3δ chain, and two CD3ε chains. These chains associate with the T-cell receptor (TCR) and the CD3-zeta (ζ-chain) to generate an activation signal in T lymphocytes. The TCR, CD3-zeta, and the other CD3 molecules together constitute the TCR complex.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-175369
    PI3Kδ-IN-25
    		Inhibitor
    PI3Kδ-IN-25 is an orally active selective PI3Kδ inhibitor (IC50 = 2.1 nM). PI3Kδ-IN-25 has IC50s of 272, 285, and 1171 nM for PI3Kα, PI3Kγ, and PI3Kβ, respectively. PI3Kδ-IN-25 inhibits AKT Ser473 phosphorylation, suppresses Treg cell proliferation, and downregulates PD-L1 expression in B16F10 cells. PI3Kδ-IN-25 exhibits anticancer effects in B16F10 melanoma and Lewis lung cancer mouse models by reducing tumor-infiltrating Treg cells and enhancing immune responses. PI3Kδ-IN-25 is potentially useful in the study of melanoma, lung cancer, and other cancers.
    PI3Kδ-IN-25
  • HY-P990692
    Ciduvectamig
    		Inhibitor
    Ciduvectamig is an anti-CD3E/TMEFF2 human IgG4 κ monoclonal antibody. Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).
    Ciduvectamig
  • HY-P990113
    Anti-Rat TCR gamma/delta Antibody (V65)
    		Inhibitor
    Anti-Rat TCR gamma/delta Antibody (V65) is a mouse-derived IgG1 κ type antibody inhibitor, targeting to rat TCR gamma/delta. Anti-Rat TCR gamma/delta Antibody (V65) can deplete γδ T cells. Anti-Rat TCR gamma/delta Antibody (V65) can be used for the research of immunology.
    Anti-Rat TCR gamma/delta Antibody (V65)
  • HY-P991686
    Gamgertamig
    		Inhibitor
    Gamgertamig is a humanized IgG4 bispecific antibody targeting TNFRSF17 & CD3E.
    Gamgertamig
  • HY-P991700
    Lumivatamig
    		Inhibitor
    Lumivatamig is an H-γ1_L-κ-scFvhl dimer-type bispecific antibody targeting CLDN18.2 & CD3E.
    Lumivatamig
  • HY-P991731
    Alveltamig
    Alveltamig (ZG006) is a trispecific anti-T cell engager (Tri-TE) targeting Delta-like ligand 3 (DLL3) and CD3. Alveltamig has two distinct DLL3 epitopes, and bridges tumor cells and T cells by strongly binding to DLL3 on tumor cells and CD3 on T cells, thereby mediating T cell-specific killing of DLL3-expressing tumor cells. Alveltamig can be used for the study of small cell lung cancer (SCLC) or neuroendocrine carcinoma (NEC).
    Alveltamig
  • HY-P991490
    ISB2001
    		Inhibitor
    ISB2001 is a human trispecific antibody (tsAb) targeting CD38 & CD3 & BCMA. BI-765423 can be used in relapsed/refractory multiple myeloma (RRMM) research. Recommended isotype control: IgG1-kappa-IgG1-Fab.
    ISB2001
  • HY-N10445
    Maydispenoid A
    Maydispenoid A is a potent immunosuppressor. Maydispenoid A can inhibit anti-CD3/anti-CD28 mAbs activated and lipopolysaccharide activated murine splenocyte proliferation.
    Maydispenoid A
  • HY-P991526
    M701
    		Inhibitor
    M701 is a humanized bispecific CD3/EpCAM T-cell engager antibody. M701 effectively kill high EpCAM expressing cancer cells. M701 can be used for the study of malignant ascites and gastric cancer.
    M701
  • HY-P991155
    Ramantamig
    		Inhibitor
    Ramantamig is a humanized monoclonal antibody targeting human CD3ε, GPRC5D, and TNFRSF17 (tumor necrosis factor receptor superfamily member 17)。Ramantamig is promising for research of cancers, especially hematological malignancies such as multiple myeloma.
    Ramantamig
  • HY-P990714
    Obertamig
    		Inhibitor
    Obertamig is an engineered, humanized, anti-CD3E/HLA-G monoclonal antibody with humanized CH2-CH3 modifications and consists of half immunoglobulin IgG1 λ2 and a single-chain variable fragment (scFv).
    Obertamig
Cat. No. Product Name / Synonyms Application Reactivity