2. Signaling Pathways
  3. Immunology/Inflammation
  4. CD3

CD3

Cluster of differentiation 3

CD3 (cluster of differentiation 3) is a protein complex and T cell co-receptor that is involved in activating both the cytotoxic T cell (CD8+ naive T cells) and T helper cells (CD4+ naive T cells). It is composed of four distinct chains. In mammals, the complex contains a CD3γ chain, a CD3δ chain, and two CD3ε chains. These chains associate with the T-cell receptor (TCR) and the CD3-zeta (ζ-chain) to generate an activation signal in T lymphocytes. The TCR, CD3-zeta, and the other CD3 molecules together constitute the TCR complex.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P990160
    Anti-Rat TCR alpha/beta Antibody (R73)
    		Inhibitor
    Anti-Rat TCR alpha/beta Antibody (R73) is a mouse-derived IgG1, κ type antibody inhibitor, targeting to rat TCR alpha/beta.
    Anti-Rat TCR alpha/beta Antibody (R73)
  • HY-P991102
    Anti-MUC17 Antibody
    		Inhibitor
    Anti-MUC17 Antibody is a human antibody expressed in CHO cells, targeting MUC17. Anti-MUC17 Antibody can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).
    Anti-MUC17 Antibody
  • HY-P991155
    Ramantamig
    		Inhibitor
    Ramantamig is a humanized monoclonal antibody targeting human CD3ε, GPRC5D, and TNFRSF17 (tumor necrosis factor receptor superfamily member 17)。Ramantamig is promising for research of cancers, especially hematological malignancies such as multiple myeloma.
    Ramantamig
  • HY-P5453
    CFP10 (71–85)
    		99.17%
    CFP10 (71–85) is a biological active peptide. (CFP1071–85, that elicited IFN-γ production and CTL activity by both CD4+ and CD8+ T cells from persons expressing multiple MHC class II and class I molecules)
    CFP10 (71–85)
  • HY-P990692
    Ciduvectamig
    		Inhibitor
    Ciduvectamig is an anti-CD3E/TMEFF2 human IgG4 κ monoclonal antibody. Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).
    Ciduvectamig
  • HY-P990714
    Obertamig
    		Inhibitor
    Obertamig is an engineered, humanized, anti-CD3E/HLA-G monoclonal antibody with humanized CH2-CH3 modifications and consists of half immunoglobulin IgG1 λ2 and a single-chain variable fragment (scFv).
    Obertamig
  • HY-P99837
    Dafsolimab
    Dafsolimab (SPV-T3a) is an IgG2a murine monoclonal antibody (anti-CD3). Dafsolimab can induce cell death through modulation and activation of the CD3/T cell receptor complex. Dafsolimab can be used for the research of graft-versus-host disease (GVHD).
    Dafsolimab
  • HY-P991163
    Tixentamig
    		Inhibitor
    Tixentamig is a bispecific monoclonal antibody targeting human CD3 ε and CLDN18 (claudin 18). Tixentamig is promising for research of cancers.
    Tixentamig
  • HY-P991197
    Anti-GPRC5D Antibody
    		Inhibitor
    Anti-GPRC5D Antibody is a humanized IgG1 monoclonal antibody that targets GPRC5D. Anti-GPRC5D Antibody is the antibody part of the ADC molecule LM-305. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).
    Anti-GPRC5D Antibody
  • HY-N10445
    Maydispenoid A
    Maydispenoid A is a potent immunosuppressor. Maydispenoid A can inhibit anti-CD3/anti-CD28 mAbs activated and lipopolysaccharide activated murine splenocyte proliferation.
    Maydispenoid A
  • HY-P991055
    Forimtamig
    		Inhibitor
    Forimtamig (RG-6324) is a GPRC5DxCD3 T-cell-engaging bispecific antibody. Forimtamig has a 2 + 1 format, comprising two high-affinity GPRC5D binding moieties and one CD3 binder. Forimtamig further features a P329G LALA mutated Fc domain that inhibits Fcγ receptor and C1q binding, yet retains binding to the neonatal Fc receptor. The isotype control for Forimtamig can refer to Human IgG1 kappa, Isotype Control (HY-P99001).
    Forimtamig
  • HY-P990932
    Obrixtamig
    		Inhibitor
    HY-P990932 is an CD3E/DLL3-targeting L-κ-G1-h-CH2-CH3_L-λ-G1-h-CH2-CH3 type human antibodychimeric antibody.
    Obrixtamig
  • HY-P991209
    Nebratamig
    		Inhibitor
    Nebratamig (GNC-035) is an anti-ROR1/anti-CD3/anti-PD-L1/anti-4-1BB tetra-specific antibody with potential immunostimulatory and antineoplastic activities.
    Nebratamig
  • HY-P991044
    Anti-Mouse CD3E Antibody (1E11.D)
    		Inhibitor
    Anti-Mouse CD3E Antibody (1E11.D) is an anti-mouse CD3E IgG1 inhibitory antibody.
    Anti-Mouse CD3E Antibody (1E11.D)
  • HY-P991122
    Besufetamig
    		Ligand
    Besufetamig is a bispecific antibody targeting programmed cell death 1 (PD-1) and CD3ε chain. Besufetamig modulates the activity of immune cells, exerting immunosuppressive and antineoplastic activities. Besufetamig is promising for research of cancers.
    Besufetamig
  • HY-P991034
    Trevotamig
    		Inhibitor
    HY-P991034 is an EPCAM/CD3E-targeting H-γ1_L-κ-scFvhl dimer type bispecific antibody.
    Trevotamig
Cat. No. Product Name / Synonyms Application Reactivity