2. Signaling Pathways
  3. Anti-infection
  4. Beta-lactamase
  5. Serine β-lactamase (SBL) Isoform
  6. Serine β-lactamase (SBL) Inhibitor

Serine β-lactamase (SBL) Inhibitor

Serine β-lactamase (SBL) Inhibitor (1):

Cat. No. Product Name Effect Purity
  • HY-178976
    YL6113
    		Inhibitor
    YL6113 is a potent and selective dual inhibitor of metallo-β-lactamases (MBLs) and serine-β-lactamases (SBLs). YL6113 shows inhibitory effect to MBLs, such as NDm-1, VIM-2, IMP-1, with IC50 values of 0.25, 27.16 and 3.55 μM. YL6113 shows inhibitory effect to SBLs, such as KPC-2, AmpC, OXA-48, with IC50 values of 0.2, 34.1 and 1.31 μM. YL6113 enhances the antibacterial efficacy of Meropenem (HY-13678) against carbapenem-resistant Gram-negative bacteria. YL6113 can be used for the research of infection.