2. Anti-infection
  3. Beta-lactamase
  4. YL6113

YL6113 is a potent and selective dual inhibitor of metallo-β-lactamases (MBLs) and serine-β-lactamases (SBLs). YL6113 shows inhibitory effect to MBLs, such as NDm-1, VIM-2, IMP-1, with IC50 values of 0.25, 27.16 and 3.55 μM. YL6113 shows inhibitory effect to SBLs, such as KPC-2, AmpC, OXA-48, with IC50 values of 0.2, 34.1 and 1.31 μM. YL6113 enhances the antibacterial efficacy of Meropenem (HY-13678) against carbapenem-resistant Gram-negative bacteria. YL6113 can be used for the research of infection.

For research use only. We do not sell to patients.

YL6113

YL6113 Chemical Structure

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YL6113 Related Antibodies

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Metallo-β-lactamase (MBL) Serine β-lactamase (SBL)

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Description

YL6113 is a potent and selective dual inhibitor of metallo-β-lactamases (MBLs) and serine-β-lactamases (SBLs). YL6113 shows inhibitory effect to MBLs, such as NDm-1, VIM-2, IMP-1, with IC50 values of 0.25, 27.16 and 3.55 μM. YL6113 shows inhibitory effect to SBLs, such as KPC-2, AmpC, OXA-48, with IC50 values of 0.2, 34.1 and 1.31 μM. YL6113 enhances the antibacterial efficacy of Meropenem (HY-13678) against carbapenem-resistant Gram-negative bacteria. YL6113 can be used for the research of infection[1].

IC50 & Target[1]

KPC-2

0.2 μM (IC50)

NDM-1

0.25 μM (IC50)

OXA-48

1.31 μM (IC50)

IMP-1

3.55 μM (IC50)

VIM-2

27.16 μM (IC50)

AmpC

34.1 μM (IC50)

In Vivo

YL6113 (10 mg/kg; IP; single dose) significantly reduces bacterial load in a murine sepsis modell when combined with Meropenem (HY-13678)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Murine sepsis model infected with NDM-1-producing K.p. 140509 strain[1]
Dosage: 10 mg/kg
Administration: Ip, a single dose
Result: Significantly reduced bacterial load in the lungs, liver, and kidneys compared to the control and Meropenem-only groups.
Molecular Weight

416.62

Formula

C18H18BClN4O5
SMILES

NCC1=CC=C(C=C1)C2=CN(N=N2)CC3=CC=C4OCB(OC4=C3C(O)=O)O.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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YL6113 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

YL6113YL 6113YL-6113Beta-lactamaseβ-lactamaseβ-lactamasesNDm-1VIM-2IMP-1KPC-2AmpCOXA-48MeropenemGram-negative bacteriaInhibitorinhibitorinhibit

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