2. Signaling Pathways
  3. Immunology/Inflammation
  4. AP-1
  5. AP-1 Activator

AP-1 Activator

AP-1 Isoform Comparison

AP-1 Activators (8):

Cat. No. Product Name Effect Purity
  • HY-P10927A
    BRP TFA
    		Activator
    BRP (BRINP2-related peptide) TFA possesses anti-obesity activity via FOS activation. BRP activates FOS in the central and acts independently of leptin, GLP-1 receptor and melanocortin 4 receptor.
  • HY-N14495
    Nidulal
    		Activator
    Nidulal induces differentiation of human promyelocytic leukemia cells. In COS-7 cells it selectively activates AP-1 dependent signal transduction.
  • HY-131670
    (±)9,10-DiHOME
    		Activator 99.90%
    (±)9,10-DiHOME is the racemate of 9,10-DiHOME. 9,10-DiHOME is a leukotoxin derivative of linoleic acid diol that has been reported to be toxic in human's tissue preparations, and is produced by inflammatory leukocytes such as neutrophils and macrophages.
  • HY-N4225
    Aaptamine
    		Activator 99.71%
    Aaptamine is an alkaloid that can be isolated from the sponge Aaptos suberitoides. Aaptamine is a competitive antagonist of the α-adrenergic receptor, as well as an inhibitor of the proteasome and cholinesterase. Aaptamine is cytotoxic to tumor cells and can induce apoptosis, cell cycle arrest of tumor cells, and the expression of p21 through a p53-independent pathway. Aaptamine has multiple activities such as anti-tumor, antioxidant, antibacterial, and analgesic effects.
  • HY-13703A
    Nimustine hydrochloride
    		Activator 98.22%
    Nimustine hydrochloride (ACNU) is the hydrochloride salt form of Nimustine (HY-13703). Nimustine hydrochloride is an alkylating agent, which induces DNA double-strand breaks (DSBs) and inter-strand crosslinks (ICLs), thereby activating the DNA damage response (DDR) signaling pathway. Nimustine hydrochloride activates p38 MAPK/JNK signaling pathway, and exhibits antitumor activity.
  • HY-P10927
    BRP
    		Activator
    BRP, a BRINP2-related peptide, possesses anti-obesity activity via FOS activation. BRP central FOS activation and acts independently of leptin, GLP-1 receptor and melanocortin 4 receptor.
  • HY-13703
    Nimustine
    		Activator
    Nimustine is an alkylating agent, which induces DNA double-strand breaks (DSBs) and inter-strand crosslinks (ICLs), thereby activating the DNA damage response (DDR) signaling pathway. Nimustine activates p38 MAPK/JNK signaling pathway, and exhibits antitumor activity.
  • HY-113443
    12(S)-HPETE
    		Activator
    12(S)-HPETE is a 12-hydroxyeicosatetraenoic acid. 12(S)-HPETE has the function of regulating vascular tone. 12(S)-HPETE induces the expression of c-Fos and c-Jun protein and increases activating protein 1 (AP-1) activity in vascular smooth muscle cells.12(S)-HPETE may play a physiological role in vasomotor regulation through endothelium itself and crosstalk between blood cells and endothelium. 12(S)-HPETE can be used in the study of cerebrovascular tension.