Amylin Receptor

AMYR

Amylin receptors (AMYRs) are G protein-coupled receptors (GPCRs), which respond to the peptide hormones amylin and calcitonin. Amylin was originally discovered as the main constituent of pancreatic islet amyloid deposits in type 2 diabetics and in diabetic cats, amylin is also a physiologically relevant circulating peptide hormone. Amylin receptors are heterodimers comprising the calcitonin receptor, which is a G protein–coupled receptor, and one of three receptor-modifying proteins. An impediment to functional studies is that it is difficult to separate amylin receptor phenotypes from calcitonin receptor phenotypes. Amylin receptors are targets for treating obesity and metabolic disorders.

Amylin Receptor Related Products (31):

By Effects:	Inhibitors (2) Ligand (1) Agonists (6) Antagonists (4)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-P2501

Amylin (8-37), human
Amylin (8-37), human is a fragment of human Amylin. Amylin (8-37), human has direct vasodilator effects in the isolated mesenteric resistance artery of the rat. Human Amylin is a small hormone secreted by pancreatic β-cells that forms aggregates under insulin deficiency metabolic conditions, and it constitutes a pathological hallmark of type II diabetes mellitus.

HY-P3926

Amylin (8-37) (human)
Amylin (8-37) (human) (hIAPP (8-37)) is a 8-37 fragment of human islet amyloid polypeptide (IAPP). The duplex folding structure in the Amylin (8-37) (human) assembly has a hairpin structure.

HY-P11269

Lenbelintide	Agonist
Lenbelintide is a dual amylin/calcitonin receptor agonist. Lenbelintide can be studied in research on obesity.

HY-P4785

Acetyl-Amylin (8-37) (human)	Antagonist
Acetyl-Amylin (8-37) (human) is a specific amylin antagonist.

HY-P4873

Amylin (20-29) (human)
Amylin (20-29) (human) is the fragment of human islet amyloid polypeptide (hIAPP) or Amylin. Amylin is a 37-residue hormone. Amylin (20-29) (human) is responsible for the amyloidogenic propensities of the full length protein. Amylin (20-29) (human) can be transformed into its corresponding peptoid and retropeptoid sequences, to obtain beta-sheet breaker peptides as amyloid inhibitors.

HY-P11245

NN1213	Agonist
NN1213 (Peptide 21), a long-acting human amylin peptide analog, is a selective Amylin receptor agonist with an EC₅₀ of 0.177 and 0.262 nM for hAMY3R and rAMY3R, respectively. NN1213 significantly reduces appetite in rat and dog models. NN1213 can be used for antiobesity research.

HY-P1871

Amylin (IAPP), feline
Amylin (IAPP), feline is a 37-amino acid polypeptide from feline. Amylin (IAPP), feline is one of the major secretory products of β-cells of the pancreatic islets. Amylin (IAPP), feline is a regulatory peptide, which inhibits insulin and glucagon secretion.

HY-P991249

NI-203	Inhibitor
NI-203 is a monoclonal antibody inhibitor that targets amylin. NI-203 is promising for research of type 2 diabetes.

HY-P0058A

Pramlintide TFA
Pramlintide TFA is a polypeptide analogue of human amylin. Pramlintide TFA, an antidiabetic agent, is antineoplastic in colorectal cancer.

HY-P4767

Amylin (1-13) (human)	Ligand
Amylin (1-13) (human) is a fragment and a residues within amyloid cores of Amylin (human IAPP). Amylin is a glucose-regulating hormone, deposits as amyloid fibrils in condition of type II diabetes (T2D). Amylin (1-13) (human) has no effect on firbl formation, as it cannot form fibrils by itself.

HY-P0058S

Pramlintide-(Ala-¹³C₃,¹⁵N)
Pramlintide-(Ala-¹³C₃,¹⁵N) is the ¹³C- and ¹⁵N-labeled Pramlintide. Pramlintide is a polypeptide analogue of human amylin. Pramlintide, an antidiabetic agent, is antineoplastic in colorectal cancer.

Name
Email *

	Sorry, but the email address you supplied was invalid.