VD/VDR

Vitamin D; Vitamin D receptor

VD/VDR

Related Products

Vitamin D is a secosteroidalprohormone, it can be synthesized at sufficient levels in skin, given adequate skin exposure to UV B radiation from sunlight. Vitamin D modulates its biological effects by directly regulating target gene expression through the Vitamin D receptor (VDR), a ligand-regulated transcription factor and a member of the nuclear receptor superfamily. Whether synthesized in the skin or ingested, vitamin D requires two hydroxylation steps to become the biologically active hormone, 1,25-dyhydroxyvitamin D₃ [1,25(OH)₂D₃], a form that signals through the VDR. The hormone-bound VDR modulates target gene transcription in response to vitamin D. VDR acts as a master transcriptional regulator of autophagy. Activation of the VDR by vitamin D induces autophagy and an autophagic transcriptional signature in breast cancer (BC) cells.

There are 2 forms of vitamin D. Vitamin D₂ (ergocalciferol) comes from irradiation of the yeast and plant sterol ergosterol, and vitamin D₃ (cholecalciferol) is found in oily fish and cod liver oil and is made in the skin. Vitamin D represents vitamin D₂ and vitamin D₃.

Topical agents containing active vitamin D₃ (calcitriol, 1α, 25- dihydroxyvitaminD₃, VD₃) analogues such as Tacalcitol, Calcipotriol and Maxacalcitol are widely used for psoriasis therapy.

VD/VDR Related Products (147)
Antibodies (3)

By Effects:	Controls (2) Inhibitors (4) Ligand (1) Agonists (19) Antagonists (15) Activators (62) Modulators (7) Chemicals (4)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-15398S

Vitamin D3-d₇	Activator
Vitamin D3-d₇ is the deuterium labeled Vitamin D3. Vitamin D3 (Cholecalciferol) is a naturally occuring form of vitamin D. Vitamin D3 induces cell differentiation and prevents proliferation of cancer cells.

HY-32345

Elocalcitol	Agonist	99.2%
Elocalcitol (BXL-628), a vitamin D analogue, is a selective, orally active vitamin D receptor (VDR) agonist. Elocalcitol shows anti-inflammatory activity. Elocalcitol inhibits growth of prostate cancer cells.

HY-U00017

Coumetarol	Antagonist	98.94%
Coumetarol (Dicumoxane) is a vitamin K antagonist.

HY-15267

MC 976	Activator
MC 976 is a Vitamin D3 derivative.

HY-75035

Calcipotriol Impurity C	Activator	99.20%
Calcipotriol Impurity C is the impurity of Calcipotriol, Calcipotriol is a ligand of VDR-like receptors.

HY-13293

Impurity C of Calcitriol	Activator	99.84%
Impurity C of Calcitriol is the impurity of Calcitriol (HY-10002). Calcitriol is the hormonally active form of vitamin D. Calcitriol is the active metabolite of vitamin D3 that activates the vitamin D receptor (VDR).

HY-32338

Tacalcitol monohydrate	Activator	99.85%
Tacalcitol monohydrate (1,24(R)-Dihydroxyvitamin D3; 1.alpha.,24R-Dihydroxyvitamin D3 monohydrate) can promote normal bone growth by regulating calcium ions. Tacalcitol monohydrate inhibits cancer cell proliferation and migration. Tacalcitol monohydrate can be used in the research of inflammation, cancer, and skin diseases.

HY-76802

Calcitriol Derivatives	Activator	99.55%
Calcitriol Derivatives is a vitamin D3 analog.

HY-13294

Impurity C of Alfacalcidol	Activator	99.81%
Impurity of Alfacalcidol. Alfacalcidol (1-hydroxycholecalciferol; Alpha D3; 1.alpha.-Hydroxyvitamin D3) is a non-selective VDR activator medication.

HY-B0918

Chlorindione		98.03%
Chlorindione (Chlophenadione) is a potent anticoagulant. Chlorindione also is a vitamin K1 antagonist.

HY-15285

Doxercalciferol-d₃	Activator
Doxercalciferol-d₃3 is the deuterated form of Doxercalciferol, which is a Vitamin D2 analog that acts as a vitamin D receptor activator (VDRA).

HY-10001R

Calcipotriol (Standard)	Chemical
Calcipotriol (Standard) is the analytical standard of Calcipotriol. This product is intended for research and analytical applications. Calcipotriol is a synthetic VitD₃ analogue with a high affinity for the vitamin D receptor.

HY-130705

Previtamin D3		98.68%
Previtamin D3 is an intermediate in the production of cholecalciferol (vitamin D3).

HY-76937

Impurity of Doxercalciferol	Activator
Impurity of Doxercalciferol is an impurity of doxercalciferol, which is a synthetic analog of ergocalciferol (vitamin D2), used as a agent for secondary hyperparathyroidism and metabolic bone disease, and it suppresses parathyroid synthesis and secretion.

HY-15156

1alpha, 24, 25-Trihydroxy VD2	Activator	98.21%
1alpha, 24, 25-Trihydroxy VD2 is a vitamin D analog.

HY-131961

Triciferol	Agonist	98.61%
Triciferol functions as a multiple ligand with combined VDR agonist and HDAC antagonist activities. Triciferol binds directly to the VDR (IC₅₀=87 nM), and functions as an agonist with 1,25D-like potency on several 1,25D target genes. Triciferol induces marked tubulin hyperacetylation, and augments histone acetylation. Antiproliferative and cytotoxic activities.

HY-32351AS

Calcifediol-d₆ monohydrate
Calcifediol-d₆ monohydrate is the deuterium labeled Calcifediol monohydrate. Calcifediol monohydrate (25-hydroxy Vitamin D3 monohydrate), is an effective VDR ligand and VD supplement. Calcifediol is a prohormone of the vitamin D endocrine system (VDES) and is hydroxylated in the liver to produce the active form, calcitriol. Calcifediol can rapidly increase serum VD levels.

HY-100219

CB1151
CB1151 is a 20-epi analogue of 1,25 dihydroxyvitamin D3 (VD) with potent anti-tumor effects. CB1151 inhibits MCF-7 cell growth with an IC₅₀ value of 0.82 nM.

HY-75992

trans-Doxercalciferol		98.20%
trans-Doxercalciferol is an isomer of Doxercalciferol. Doxercalciferol is a Vitamin D2 analog, acts as an activator of Vitamin D receptor, and prevent renal disease.

HY-32346

Atocalcitol
Atocalcitol, a vitamin D3 analogue, is used in the study for psoriasis.

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VD/VDR

VD/VDR

VD/VDR Related Products (147)

Antibodies (3)

VD/VDR Related Products (147):