2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Phospholipase

Phospholipase

Phospholipase

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Phospholipase is a member of a very complex group of enzymes that break down phospholipids into fatty acids and other compounds. Phospholipases are defined by the enzymatic reaction they catalyze. The classes are phospholipase A, which has members A1 and A2; phospholipase B, which can carry out the reactions of both A1 and A2; phospholipase C; and phospholipase D.

Phospholipase A2 (PLA2) catalyses the hydrolysis of the sn-2 position of glycerophospholipids to yield fatty acids and lysophospholipids. Phospholipase C (PLC) converts phosphatidylinositol 4,5-bisphosphate (PIP2) to inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). DAG and IP3 each control diverse cellular processes and are also substrates for synthesis of other important signaling molecules. PLC is thus central to many important interlocking regulatory networks. Phospholipase D (PLD) is an essential enzyme responsible for the production of the lipid second messenger phosphatidic acid (PA), which is involved in fundamental cellular processes, including membrane trafficking, actin cytoskeleton remodeling, cell proliferation and cell survival.

Phospholipase Isoform Specific Products:

Phospholipase Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-171033
    ASM-IN-3
    		Inhibitor
    ASM-IN-3 (Compound 21b) is a selective and BBB-penetrating acid sphingomyelinase (ASM) inhibitor (IC50: 3.37 μM for pure human ASM). ASM-IN-3 improves depression-like behaviors by inhibiting ASM activity and increasing neurogenesis in hippocampus in Reserpine (HY-N0480)-induced depressed rats.
    ASM-IN-3
  • HY-18570R
    1-Naphthaleneacetic acid (Standard)
    		Inhibitor
    1-Naphthaleneacetic acid (Standard) is the analytical standard of 1-Naphthaleneacetic acid. This product is intended for research and analytical applications. 1-Naphthaleneacetic acid (1-Naphthylacetic acid), a auxin, can promote plant growth. 1-Naphthaleneacetic acid is also an inhibitor of PLA2, with an IC50 of 13.16 μM.
    1-Naphthaleneacetic acid (Standard)
  • HY-170650
    SMase-IN-1
    		Inhibitor
    SMase-IN-1 (Compound 4) is a bacterial sphingomyelinase enzyme (SMase) inhibitor (IC50 value for B. cereus SMase is 6.43 µM). SMase-IN-1 also inhibits eqBuChE (59.50% inhibition rate at 50 µM concentration). SMase-IN-1 forms a complex with Cu2+ in biometal interactions. SMase-IN-1 reduces B. cereus-induced hemolysis on sheep erythrocytes.
    SMase-IN-1
  • HY-N14105
    Cinatrin C3
    		Inhibitor
    Cinatrin C3 is a phospholipase A2 (PLA2) inhibitor with an IC50 of 70 μM and can be extracted from Circinotrichum falcatisporum RF-641.
    Cinatrin C3
  • HY-120078
    AZD2716
    		Inhibitor
    AZD2716 is a selective sPLA2 (secretory phospholipase A2) inhibitor. AZD2716 significantly reduces the production of pro-inflammatory lipids by inhibiting sPLA2-IIa (IC50 = 10 nM), sPLA2-V (IC50 = 40 nM), and sPLA2-X (IC50 = 400 nM), thereby decreasing macrophage activation and foam cell formation. AZD2716 is promising for studying mechanisms related to atherosclerosis and inflammatory diseases associated with sPLA2.
    AZD2716
  • HY-N14103
    Cinatrin C1
    		Inhibitor
    Cinatrin C1 is a phospholipase A2 (PLA2) inhibitor that can be extracted from Circinotrichum falcatisporum RF-641.
    Cinatrin C1
  • HY-116273
    ML299
    		Inhibitor
    ML299 is a selective allosteric modulator and a dual inhibitor of phospholipases D1 and D2 (IC50 values are 6 and 12 nM, respectively). ML299 decreases invasive migration in U87-MG glioblastoma cells.
    ML299
  • HY-P10658
    ARF1 (2-17)
    		Inhibitor
    ARF1 (2-17) inhibits both ARF-independent (PLC-β) and ARF-dependent (PLD) pathways. ARF1 (2-17) inhibits GTP-γ-S-stimulated PLD activity, phospholipase C-β (PLC-β), and exocytosis.
    ARF1 (2-17)
  • HY-17569R
    Difluprednate (Standard)
    		Inhibitor
    Difluprednate (Standard) is the analytical standard of Difluprednate. This product is intended for research and analytical applications. Difluprednate is a topical corticosteroid, which is thought to act by the induction of phospholipase A2 inhibitory proteins (lipocortins). Difluprednate is used for the symptomatic treatment of inflammation and pain associated with ocular surgery.
    Difluprednate (Standard)
  • HY-10521R
    Darapladib (Standard)
    		Inhibitor
    Darapladib (Standard) is the analytical standard of Darapladib. This product is intended for research and analytical applications. Darapladib (SB-480848) is an orally active, selective and reversible Lp-PLA2 inhibitor (IC50=0.25 nM). Darapladib can trigger irreversible actions on glioma cell apoptosis and induce cycle arrest. Darapladib can be used in the study of atherosclerosis and cancer[1][2][3][4].
    Darapladib (Standard)
  • HY-N14101
    Cinatrin B
    		Inhibitor
    Cinatrin B has the activity of inhibiting phospholipase A2.
    Cinatrin B
  • HY-115855
    Ro 31-4639
    		Inhibitor
    Ro 31-4639 is a potent phospholipase A2 inhibitor with an IC50 of 1.5 μM.
    Ro 31-4639
  • HY-127110
    AK106-001616
    		Inhibitor
    AK106-001616 is a potent and selective inhibitor of cytosolic phospholipase A2 (cPLA2) (IC50=3.8 nmol/L). AK106-001616 is able to reduce the production of prostaglandins (PG) E2 and leukotrienes (LT) B4 by stimulated cells. AK106-001616 can be used in the study of inflammatory diseases, neuropathic pain and pulmonary fibrosis.
    AK106-001616
  • HY-19151B
    Fuzapladib potassium
    		Inhibitor
    Fuzapladib (IS-741) potassium, an orally active leukocyte-function-associated antigen type 1 (LFA-1) activation inhibitor, is a leukocyte adhesion molecule. Fuzapladib potassium is also a phospholipase A2 (PLA2) inhibitor. Fuzapladib potassium exerts anti-inflammatory effects by inhibiting leukocyte migration into the inflammatory site.
    Fuzapladib potassium
  • HY-117068
    (R)-Bromoenol lactone
    		Inhibitor
    (R)-Bromoenol lactone ((R)-BEL) is an irreversible, chiral, mechanism-based inhibitor of calcium-independent phospholipase γ (iPLA2γ). (R)-BEL inhibits human recombinant iPLA2γ with an IC50 of approximately 0.6 µM.
    (R)-Bromoenol lactone
  • HY-B0113S4
    Omeprazole-d3 sodium
    		Inhibitor
    Omeprazole-d3 sodium is deuterated labeled Omeprazole (HY-B0113). Omeprazole (H 16868), a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole shows competitive inhibition of CYP2C19 activity with a Ki of 2 to 6 μM. Omeprazole also inhibits growth of Gram-positive and Gram-negative bacteria.Omeprazole is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor).
    Omeprazole-d<sub>3</sub> sodium
  • HY-131002A
    DPTIP hydrochloride
    		Inhibitor
    DPTIP hydrochloride is a potent brain penetrant neutral sphingomyelinase 2 (N-SMase 2) inhibitor (exosome inhibitor), with an IC50 of 30 nM.
    DPTIP hydrochloride
  • HY-117068S
    (R)-Bromoenol lactone-d7
    		Inhibitor
    (R)-Bromoenol lactone-d7 ((R,E)-Bromoenol lactone-d7) is deuterium labeled (R)-Bromoenol lactone. (R)-Bromoenol lactone ((R)-BEL) is an irreversible, chiral, mechanism-based inhibitor of calcium-independent phospholipase γ (iPLA2γ). (R)-BEL inhibits human recombinant iPLA2γ with an IC50 of approximately 0.6 μM.
    (R)-Bromoenol lactone-d<sub>7</sub>
  • HY-158734
    Methyl γ-linolenyl fluorophosphonate
    		Inhibitor
    Methyl γ-linolenyl fluorophosphonate (MγLnFP) is a close analog of a well-characterized, irreversible inhibitor of phospholipases, methyl arachidonyl fluorophosphonate (MAFP).
    Methyl γ-linolenyl fluorophosphonate
  • HY-136994
    Sphingolactone-24
    		Inhibitor
    Sphingolactone-24 (Sph-24) is a selective and irreversible neutral sphingomyelinase (nSMase) inhibitor. Sphingolactone-24 has the potential for the research of acute lung injury.
    Sphingolactone-24
Cat. No. Product Name / Synonyms Application Reactivity
Phospholipase Isoform Comparison

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