2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Phospholipase

Phospholipase

Phospholipase

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Phospholipase is a member of a very complex group of enzymes that break down phospholipids into fatty acids and other compounds. Phospholipases are defined by the enzymatic reaction they catalyze. The classes are phospholipase A, which has members A1 and A2; phospholipase B, which can carry out the reactions of both A1 and A2; phospholipase C; and phospholipase D.

Phospholipase A2 (PLA2) catalyses the hydrolysis of the sn-2 position of glycerophospholipids to yield fatty acids and lysophospholipids. Phospholipase C (PLC) converts phosphatidylinositol 4,5-bisphosphate (PIP2) to inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). DAG and IP3 each control diverse cellular processes and are also substrates for synthesis of other important signaling molecules. PLC is thus central to many important interlocking regulatory networks. Phospholipase D (PLD) is an essential enzyme responsible for the production of the lipid second messenger phosphatidic acid (PA), which is involved in fundamental cellular processes, including membrane trafficking, actin cytoskeleton remodeling, cell proliferation and cell survival.

Phospholipase Isoform Specific Products:

Phospholipase Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-177003
    SM (d18:1/15:0)
    		Inhibitor
    SM (d18:1/15:0) is a sphingomyelinase inhibitor. SM (d18:1/15:0) is promising for research of neurodegenerative diseases (e.g., Alzheimer's) and metabolic syndrome.
    SM (d18:1/15:0)
  • HY-118725
    Luffariellolide
    		Inhibitor
    Luffariellolide is an inhibitor of human synovial fluid phospholipase A2 (HSF-PLA2) (IC50=5 μM). Luffariellolide effectively inhibits phorbol ester (PMA)-induced ear edema (ED50=50 μg/ear).
    Luffariellolide
  • HY-129944
    MJ33-OH
    		Inhibitor
    MJ33-OH is a metabolite of MJ33. MJ33 is an active-site-directed, specific, competitive, and reversible phospholipase A2 (PLA2) inhibitor. MJ33 blocks the calcium-independent phospholipase A2 (iPLA2) activity of Prdx6.
    MJ33-OH
  • HY-153561
    Lp-PLA2-IN-15
    		Inhibitor
    Lp-PLA2-IN-15 (example 2) is a lipoprotein-associated phospholipase A2 (Lp-PLA 2) inhibitor, which can be used in the research of Alzheimer's disease, etc.
    Lp-PLA2-IN-15
  • HY-153560
    Lp-PLA2-IN-14
    		Inhibitor
    Lp-PLA2-IN-14 (Compound 19) is an Lp-PLA2 inhibitor with a pIC50 of 8.4 against rhLp-PLA2. Lp-PLA2-IN-14 can be used for the research of neurodegenerative related diseases, such as Alzheimer Disease (AD), glaucoma, age-related macular degeneration (AMD) or cardiovascular diseases including atherosclerosis and the like.
    Lp-PLA2-IN-14
  • HY-D1647
    7-Hydroxycoumarinyl-γ-linolenate
    7-Hydroxycoumarinyl-γ-linolenate is a cytosolic phospholipase A2 (cPLA2) fluorogenic substrate. 7-Hydroxycoumarinyl-γ-linolenate can be used to monitor the enzymatic activity of cPLA2.
    7-Hydroxycoumarinyl-γ-linolenate
  • HY-106611
    Brinazarone
    		Inhibitor
    Brinazarone (SR 33287) is an inhibitor for acid lysosomal sphingomyelinase, and leads to cellular lipidosis. Brinazarone potentiates the cytotoxic effects of anti-Thy 1.2 AT15E RTA-IT on T2 cells and anti-CD5 T101 on CEM cells.
    Brinazarone
  • HY-P3906
    Melittin free acid
    		Activator
    Melittin free acid is a basic 26-amino-acid polypeptide, the major active ingredient of honeybee venom. Melittin free acid is an activator of phospholipase A2 (PLA2). Melittin free acid has broad-spectrum antifungal activity with MIC values of 0.4-60 μM. Melittin free acid hinders fungal growth by inducing cell apoptosis, repressing (1,3)-β-D-glucan synthase and participating in other pathways.
    Melittin free acid
  • HY-169254
    sPLA2 inhibitor 2
    		Inhibitor
    sPLA2 inhibitor 2 (compound 6a) is a sPLA2 inhibitor, with IC50 of 0.0475 μM. sPLA2 inhibitor 2 can be used in diabetes research.
    sPLA2 inhibitor 2
  • HY-19415B
    SB-435495 ditartrate
    		Inhibitor
    SB-435495 ditartrate is a potent, selective, reversible, non-covalent and orally active Lp-PLA2 inhibitor with an IC50 of 0.06 nM.
    SB-435495 ditartrate
  • HY-176525
    PLC-β-IN-1
    		Inhibitor
    PLC-β-IN-1 (Compound 8a) is a PLCβ inhibitor. PLC-β-IN-1 exerts anti-airway contraction activity by inhibiting PLCβ and its downstream signaling pathways, and can enhance the airway relaxation effect of β-agonists. PLC-β-IN-1 can be used in the study of asthma.
    PLC-β-IN-1
  • HY-101579
    LY 178002
    		Antagonist
    LY 178002 is a potent inhibitor of 5-lipoxygenase (5-LPO), phospholipase A2, with IC50 of 0.6 μM for 5-lipoxygenase, inhibits cellular production of LTB4 by human polymorphonuclear leukocytes, and shows relatively weak inhibition on cyclooxygenase.
    LY 178002
  • HY-171962
    KARI 201
    		Inhibitor
    KARI 201 is a selective, brain penetrant pand competitive acid sphingomyelinase (ASM) inhibitor with an IC50 of 338.3?nM. KARI 201 is a ghrelin receptor agonist. KARI 201 improves neuropathological features of Alzheimer's disease.
    KARI 201
  • HY-125157
    Me-Indoxam
    		Inhibitor
    Me-Indoxam is a potent and cell-impermeable secreted phospholipase A2 (sPLA2) inhibitor.
    Me-Indoxam
  • HY-177450
    DS07551382
    		Inhibitor
    DS07551382 is a potent phosphatidylserine synthase 1 (PTDSS1) inhibitor, thereby blocking intracellular phosphatidylserine synthesis. DS07551382 has antitumor activity.
    DS07551382
  • HY-138871
    cPLA2α-IN-derivative 1
    		Control
    cPLA2α-IN-derivative 1 is an inactive alcohol derivative of a highly potent Cytosolic phospholipase A2α (cPLA2α) inhibitor.
    cPLA2α-IN-derivative 1
  • HY-155343
    A4333
    		Inhibitor
    A4333 is biotinylated compound of A3373 (HY-155342) that inhibits Phospholipase D1 (PLD1), but not PLD2. A4333 plays an important role in antitumor activity.
    A4333
  • HY-153561A
    Lp-PLA2-IN-16
    		Inhibitor
    Lp-PLA2-IN-16 (example 1) is a lipoprotein-associated phospholipase A2 (Lp-PLA 2) inhibitor, which can be used in the research of Alzheimer's disease, etc.
    Lp-PLA2-IN-16
  • HY-19151C
    Fuzapladib calcium
    		Inhibitor
    Fuzapladib calcium, an orally active leukocyte-function-associated antigen type 1 (LFA-1) activation inhibitor, is a leukocyte adhesion molecule. Fuzapladib calcium is also a phospholipase A2 (PLA2) inhibitor. Fuzapladib calcium exerts anti-inflammatory effects by inhibiting leukocyte migration into the inflammatory site.
    Fuzapladib calcium
  • HY-23909
    7,7-Dimethyl-(5Z,8Z)-eicosadienoic acid
    		Inhibitor
    7,7-Dimethyl-(5Z,8Z)-eicosadienoic acid (DEDA), a phospholipase inhibitor, is a non-metabolizable analog of arachidonic or eicosadienoic acid. 7,7-Dimethyl-(5Z,8Z)-eicosadienoic acid (DEDA) inhibits P388D1 cell phospholipase A2 (PLA2) (IC50 = 16 µM) and snake venom PLA2 (IC50 = 14 µM).
    7,7-Dimethyl-(5Z,8Z)-eicosadienoic acid
Cat. No. Product Name / Synonyms Application Reactivity
Phospholipase Isoform Comparison

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