2. Signaling Pathways
  3. Epigenetics
    TGF-beta/Smad
  4. PKC

PKC

Protein kinase C

PKC

Related Products

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PKC (Protein kinase C) is a family of protein kinase enzymes that are involved in controlling the function of otherproteins through the phosphorylation of hydroxyl groups of serine and threonine amino acid residues on these proteins. PKC enzymes in turn are activated by signals such as increases in the concentration of diacylglycerol (DAG) or calcium ions (Ca2+). Hence PKC enzymes play important roles in several signal transduction cascades. The PKC family consists of 15 isozymes in humans: PKC-α (PRKCA), PKC-β1 (PRKCB), PKC-β2 (PRKCB), PKC-γ (PRKCG), PKC-δ (PRKCD), PKC-δ1 (PRKD1), PKC-δ2 (PRKD2), PKC-δ3 (PRKD3), PKC-ε (PRKCE), PKC-η (PRKCH), PKC-θ (PRKCQ), PKC-ι (PRKCI), PKC-ζ (PRKCZ), PK-N1 (PKN1), PK-N2 (PKN2), PK-N3 (PKN3). PKC is involved in receptor desensitization, in modulating membrane structure events, in regulating transcription, in mediating immune responses, in regulating cell growth, and in learning and memory. These functions are achieved by PKC-mediated phosphorylation of other proteins.

PKC Isoform Specific Products:

PKC Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-121828
    TX-1123
    		Inhibitor
    TX-1123 is a potent protein tyrosine kinase (PTK) inhibitor for Src, eEF2-K, and PKA, and EGFR-K/PKC. TX-1123 is a cyclo-oxygenase (COX) inhibitor with IC50 values of 1.16 μM and 15.7 μM for COX2 and COX1, respectively. TX-1123 has low mitochondrial toxicity. TX-1123 can be used in research of cancer.
    TX-1123
  • HY-131305
    HBDDE
    		Inhibitor 98.03%
    HBDDE, a derivative of Ellagic acid, is an isoform-selective PKCα and PKCγ inhibitor with IC50s of 43 μM and 50 μM, respectively. HBDDE shows selective for PKCα/PKCγ over PKCδ, PKCβI and PKCβII isozymes. HBDDE induces neuronal apoptosis.
    HBDDE
  • HY-P1402
    [Glu27]-PKC (19-36)
    [Glu27]-PKC (19-36) is an inactive control for protein kinase C (PKC) (19-36). PKC (19-36) is a pseudosubstrate peptide inhibitor of protein kinase C, it may be responsible for maintaining the enzyme in the inactive form in the absence of allosteric activators such as phospholipids.
    [Glu27]-PKC (19-36)
  • HY-P1284A
    ZIP TFA
    		Inhibitor
    ZIP TFA is a selective peptide inhibitor of PKMζ. ZIP TFA injections can block the impairment in morphine conditioned place preference induced.
    ZIP TFA
  • HY-149490
    AJH-836
    		Activator
    AJH-836 is an activator of Munc13-1 and PKC ε/α (Kd: 4.5 nM for PKCα) . AJH-836 triggers the translocation of Munc13-1 from the cytoplasm to the plasma membrane. AJH-836 can be used for research of neurodegenerative diseases.
    AJH-836
  • HY-N0278
    Anemonin
    		Inhibitor
    Anemonin (Pulsatilla camphor), a selective iNOS inhibitor, is also a PKC-θ inhibitor. Anemonin can significantly inhibit the translation or protein stability of PKC-θ protein. Anemonin also ameliorates dextran sodium sulfate-induced acute ulcerative colitis (UC) in mice. Anemonin can be used in the research of inflammation-related diseases.
    Anemonin
  • HY-115767
    (±)-1,2-Diolein
    		Activator
    (±)-1,2-Diolein (1,2-Dioleoyl-rac-glycerol) is a PKC activator. (±)-1,2-Diolein increases myotubes Ca2+ influx.
    (±)-1,2-Diolein
  • HY-RS11139
    Prkcq Rat Pre-designed siRNA Set A
    		Inhibitor

    Prkcq Rat Pre-designed siRNA Set A contains three designed siRNAs for Prkcq gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Prkcq Rat Pre-designed siRNA Set A
  • HY-129099AR
    N-Desmethyltamoxifen hydrochloride (Standard)
    		Inhibitor
    N-Desmethyltamoxifen (hydrochloride) (Standard) is the analytical standard of N-Desmethyltamoxifen (hydrochloride). This product is intended for research and analytical applications. N-Desmethyltamoxifen hydrochloride is the major metabolite of tamoxifen in humans. N-Desmethyltamoxifen, a poor antiestrogen, is a ten-fold more potent protein kinase C (PKC) inhibitor than Tamoxifen. N-Desmethyltamoxifen hydrochloride is also a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation[1][2][3].
    N-Desmethyltamoxifen hydrochloride (Standard)
  • HY-RS11127
    Prkce Rat Pre-designed siRNA Set A
    		Inhibitor

    Prkce Rat Pre-designed siRNA Set A contains three designed siRNAs for Prkce gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Prkce Rat Pre-designed siRNA Set A
  • HY-RS11123
    Prkcd Mouse Pre-designed siRNA Set A
    		Inhibitor

    Prkcd Mouse Pre-designed siRNA Set A contains three designed siRNAs for Prkcd gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Prkcd Mouse Pre-designed siRNA Set A
  • HY-P3841
    Protein Kinase C β Peptide
    Protein Kinase C (beta) Peptide is a peptide fragment of Protein Kinase Cβ. Protein Kinase Cβ is related with hyperglycemia decreases endothelium-derived nitric oxide. Inhibition of Protein kinase Cβ prevents the reduction in endothelium-dependent vasodilation induced by acute hyperglycemia.
    Protein Kinase C β Peptide
  • HY-108601
    (S)-Ro 32-0432 free base
    		Inhibitor
    (S)-Ro 32-0432 free base is a potent, selective, ATP-competitive and orally active PKC inhibitor. The IC50 values of (S)-Ro 32-0432 free base for PKCα, PKCβI, PKCβII, PKCγ and PKCε are 9.3 nM, 28 nM, 30 nM, 36.5 nM and 108.3 nM, respectively. (S)-Ro 32-0432 free base is also a selective G protein-coupled receptor kinase 5 (GRK5) inhibitor. (S)-Ro 32-0432 free base prevents T-cell activation and has the potential for chronic inflammatory and autoimmune diseases research.
    (S)-Ro 32-0432 free base
  • HY-RS11137
    PRKCQ Human Pre-designed siRNA Set A
    		Inhibitor

    PRKCQ Human Pre-designed siRNA Set A contains three designed siRNAs for PRKCQ gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    PRKCQ Human Pre-designed siRNA Set A
  • HY-115769
    1,2-Didecanoylglycerol
    		Activator
    1,2-Didecanoylglycerol, a synthetic diacylglycerol, is metabolized by platelets to 1,2-didecanoylphosphatidic acid (PA10) and activates protein kinase C (PKC).
    1,2-Didecanoylglycerol
  • HY-P1286
    PKC β pseudosubstrate
    		Inhibitor 98.98%
    PKC β pseudosubstrate is a selective cell-permeable inhibitor of PKC.
    PKC β pseudosubstrate
  • HY-P5877
    ɛPKC(85–92),Myristoylated
    		Activator
    PKC(85–92),Myristoylated is a cell permeable myristic acid conjugated PKC peptide activator that enhances NO release in cultured human umbilical vein endothelial cells (HUVECs).
    ɛPKC(85–92),Myristoylated
  • HY-RS11135
    Prkci Mouse Pre-designed siRNA Set A
    		Inhibitor

    Prkci Mouse Pre-designed siRNA Set A contains three designed siRNAs for Prkci gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Prkci Mouse Pre-designed siRNA Set A
  • HY-118384R
    Sangivamycin (Standard)
    		Inhibitor
    Sangivamycin (Standard) is the analytical standard of Sangivamycin. This product is intended for research and analytical applications. Sangivamycin (NSC 65346), a nucleoside analog, is a potent inhibitor of protein kinase C (PKC) with an Ki of 10 μM. Sangivamycin has potent antiproliferative activity against a variety of human cancers[1][2].
    Sangivamycin (Standard)
  • HY-RS11117
    Prkca Mouse Pre-designed siRNA Set A
    		Inhibitor

    Prkca Mouse Pre-designed siRNA Set A contains three designed siRNAs for Prkca gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Prkca Mouse Pre-designed siRNA Set A
Cat. No. Product Name / Synonyms Application Reactivity
PKC Isoform Comparison

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