Na+/K+ ATPase

Sodium potassium pump

Na+/K+ ATPase

Related Products

Na⁺/K⁺ ATPase (Sodium potassium pump) is a transmembrane protein complex found in all higher eukaryotes acting as a key energy-consuming pump maintaining ionic and osmotic balance in cells. Na⁺/K⁺ ATPase is an emerging cancer target that merits further investigation.

The constant activity of the Na⁺/K⁺-ATPase (NKA, or Na⁺ pump) is essential for re-establishing and maintaining this gradient. In cardiac and vascular smooth muscle the principal isoforms of the NKA are α1 and α2 and their physiological role is controlled both by their unique and independent signalling pathways, and their discrete subcellular distribution.

Na+/K+ ATPase Related Products (113)
Antibodies (11)

By Effects:	Control (1) Inhibitors (83) Antagonists (2) Activators (13) Modulators (4)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-N1446

Oleic acid	Activator	99.97%
Oleic acid (9-cis-Octadecenoic acid) is an abundant monounsaturated fatty acid. Oleic acid is a Na⁺/K⁺ ATPase activator.

HY-N1446B

Oleic acid sodium	Activator	99.44%
Sodium oleate (Oleic acid sodium) is an abundant monounsaturated fatty acid sodium. Sodium oleate is a Na⁺/K⁺ ATPase activator.

HY-N0039

Ginsenoside Rb1	Inhibitor	99.75%
Ginsenoside Rb1, a main constituent of the root of Panax ginseng, inhibits Na⁺, K⁺-ATPase activity with an IC₅₀ of 6.3±1.0 μM. Ginsenoside also inhibits IRAK-1 activation and phosphorylation of NF-κB p65 .

HY-N0877

Bufalin	Inhibitor	99.86%
Bufalin is an active component isolated from Chan Su, acts as a potent Na⁺/K⁺-ATPase inhibitor, binds to the subunit α1, α2 and α3, with K_d of 42.5, 45 and 40 nM, respectively. Anti-cancer activity.

HY-N0143

Phlorizin	Inhibitor	99.93%
Phlorizin (Floridzin) is a non-selective SGLT inhibitor with K_is of 300 and 39 nM for hSGLT1 and hSGLT2, respectively. Phlorizin is also a Na⁺/K⁺-ATPase inhibitor.

HY-126751

DBM-819	Inhibitor
DBM-819 is a reversible inhibitor of H⁺/K⁺-ATPase (H⁺/K⁺-ATPase), with an IC₅₀ value of 5 μM. DBM-819 can reversibly block gastric acid secretion by inhibiting the proton pump in the gastric mucosa. It shows significant protective effects against duodenal ulcers induced by Cysteamine (HY-77591), gastric ulcers induced by Indomethacin (HY-14397), and gastric ulcers induced by Aspirin (HY-14654), with EC₅₀ values of 6, 3.1, and 4 mg/kg respectively. DBM-819 can be used in ulcer prevention research.

HY-165498

AU-461	Inhibitor
AU-461 is an orally active and reversible inhibitor of the gastric H⁺/K⁺ ATPase with IC₅₀ values for rabbit-derived and pig-derived enzymes are 12.15 μM and 4.20 μM respectively. AU-461 competes with activated cationic K⁺ (Kᵢ = 1.64 μM). AU-461 reduces both histamine-stimulated gastric acid secretion and basal gastric acid secretion in rats. AU-461 inhibits ulcer formation caused by ethanol or sodium hydroxide, and restores the plasma gastrin level to normal. AU-461 can be used for the study of peptic ulcers.

HY-113738

ADN 138	Activator
ADN-138 is an aldose reductase inhibitor. ADN-138 reduces sorbitol levels in diabetic nerves and results in significant increases in MNCV and Na⁺, K⁺-ATPase in the nerves. ADN-138 can be used in the research of diabetic nerve complications.

HY-B1357

Digitoxin		99.22%
Digitoxin is an anti-cancer agent. Digitoxin induces apoptosis, inhibits influenza cytokine storm, causes DNA double-stranded breaks (DSBs) and blocks the cell cycle at the G2/M phase. Digitoxin induces calcium uptake into cells by forming transmembrane calcium channels and can be used for research of heart failure .

HY-B0401

Tolbutamide	Inhibitor	99.96%
Tolbutamide is an orally active K_ATP inhibitor. Tolbutamide inhibits cell proliferation, stimulates exocytosis of glucagon and reduces fetal lethality of mice. Tolbutamide can be used in the research of diabete.

HY-N1446S2

Oleic acid-¹³C₁₈	Activator	99.90%
Oleic acid-¹³C₁₈ is the ¹³C labeled Oleic acid (HY-N1446). Oleic acid (9-cis-Octadecenoic acid) is an abundant monounsaturated fatty acid. Oleic acid is a Na+/K+ ATPase activator.

HY-A0154

Deslanoside	Inhibitor	99.79%
Deslanoside (Desacetyllanatoside C) is a rapidly acting cardiac glycoside used to treat congestive heart failure and supraventricular arrhythmias due to reentry mechanisms, and to control ventricular rate in the treatment of chronic atrial fibrillation. Deslanoside inhibits the Na-K-ATPase membrane pump, resulting in an increase in intracellular sodium and calcium concentrations .

HY-15718A

Istaroxime hydrochloride	Inhibitor	99.32%
Istaroxime hydrochloride is a Na⁺/K⁺-ATPase inhibitor (IC₅₀=0.11 μM) and a sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA 2) activator.

HY-B0887

Permethrin	Inhibitor	99.84%
Permethrin (NRDC-143) is an insecticide, acaricide and a high selectively inhibitor of the Mitochondrial complex I, found in sediment and water samples. Permethrin shows estrogenic in vivo and anti-estrogenic activity in vitro. Permethrin also acts as a neurotoxin affecting neuron membranes by prolonging Sodium channel activation. Permethrin decreases resistance to bacterial infections in medaka (Oryzias latipes).

HY-12283

Rostafuroxin	Antagonist	99.03%
Rostafuroxin (PST 2238), a digitoxigenin derivative, is an orally active and potent Na⁺,K⁺-ATPase (ATP1A1) antognist. Rostafuroxin binds specifically to the ATP1A1 extracellular domain and blocks respiratory syncytial virus (RSV)-triggered EGFR Tyr845 phosphorylation. Rostafuroxin has antihypertensive and anti-RSV activity.

HY-P5712

Gramicidin S	Inhibitor	99.89%
Gramicidin S (Gramicidin soviet) is a cationic cyclic peptide antibiotic that selectively targets bacterial cell membranes and has anticancer activity. Gramicidin S also exerts antibacterial activity by destroying membrane integrity and interfering with membrane protein function. Gramicidin S inserts into the phospholipid bilayer through hydrophobic amino acid residues, specifically binds to negatively charged membrane lipids and disrupts membrane structure, thereby inhibiting cell division and cell wall synthesis, and ultimately causing bacterial death. Gramicidin S also inhibits ion channels, with IC₅₀s of 41 μM, 24 μM, and 3 μM for Na⁺/K⁺-ATPase, tobacco leaf plasma membrane Mg²⁺/K⁺-ATPase, and rat heart plasma membrane Ca²⁺-ATPase, respectively.

HY-Y0413

Biacetyl monoxime	Inhibitor	98.0%
Biacetyl monoxime (Diacetyl monoxime), a myosin ATPase inhibitor, is a skeletal and cardiac muscle contraction inhibitor. Biacetyl monoxime is also a well-characterized non-competitive inhibitor of chemical and motile activity of skeletal muscle myosin-II. Biacetyl monoxime induces sarcoplasmic reticulum Ca²⁺ release.

HY-N1446S1

Oleic acid-d₂	Activator	99.60%
Oleic acid-d₂) is the deuterium labeled Oleic acid (HY-N1446). Oleic acid (9-cis-Octadecenoic acid) is an abundant monounsaturated fatty acid]. Oleic acid is a Na+/K+ ATPase activator.

HY-114252

Strophanthidin	Inhibitor	98.53%
Strophanthidin is a naturally available cardiac glycoside. Strophanthidin 0.1 and 1 nmol/L increases and 1~100 μmol/L inhibits the Na+/K+-ATPase activities, but Strophanthidin 10 and 100 nmol/L does not affect Na+/K+-ATPase activities in cardiac sarcolemmal. Strophanthidin increases both diastolic and systolic intracellular Ca²⁺ concentration.

HY-D1435

Oxonol VI		98.91%
Oxonol VI is an optical indicator of membrane potential in lipid vesicles (excitation/emission wavelengths: 614/646 nm). Oxonol VI can be used to detect changes in membrane potential associated with (Na⁺ + K⁺)-ATPase activity in reconstituted vesicles.

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Na+/K+ ATPase

Na+/K+ ATPase

Na+/K+ ATPase Related Products (113)

Antibodies (11)

Na+/K+ ATPase Related Products (113):