2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Endogenous Metabolite

Endogenous Metabolite

Endogenous Metabolite

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Metabolite results when a drug is metabolized into a modified form which continues to produce effects. A metabolome in a given body fluid is influenced by endogenous factors such as age, sex, body composition and genetics as well as underlying pathologies.The levels of the enormous array of unique small-molecule metabolites are usually kept tightly regulated by the activity of a very large array of enzymes and transporters responsible for the production, transformation, degradation, and compartmentalization of these small molecules.The levels of the endogenous small molecules present in the brain are normally tightly regulated.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N1428S1
    Citric acid-13C6
    		99.90%
    Citric acid-13C6 is the 13C-labeled Citric acid (HY-N1428). Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid is also an acidulant, emulsifier, sequestrant and buffering agent widely used across many industries.
    Citric acid-<sup>13</sup>C<sub>6</sub>
  • HY-W009310
    9-cis-Retinal
    		99.29%
    9-cis-Retinal is a natural retinoid. Dietary 9-cis-β-carotene generates 9-cis-retinoids via cleavage into 9-cis-retinal. 9-cis Retinal binds to cellular retinol-binding protein-I (CRBP-I) and CRBP-II with Kds of 8 nM and 5 nM, respectively. 9-cis-Retinal expedites differentiation and maturation of rod photoreceptors in retinal organoids.
    9-cis-Retinal
  • HY-W104368
    Nicotinic acid riboside
    		99.90%
    Nicotinic acid riboside is a NAD+ precursor in human cells. Nicotinic acid riboside is an authentic intermediate of human NAD+ metabolism.
    Nicotinic acid riboside
  • HY-N2072
    Crocetin
    		98.22%
    Crocetin (Transcrocetin), extracted from saffron (Crocus sativus L.), acts as an NMDA receptor antagonist with high affinity. Crocetin is capable of crossing the blood-brain barrier and reach the central nervous system (CNS).
    Crocetin
  • HY-W013049
    Docosanoic acid
    		≥98.0%
    Docosanoic acid (Behenic acid) is a long-chain saturated fatty acid. Docosanoic acid inhibits the double-stranded DNA (dsDNA) binding activity of p53 DNA binding domain, with a Kd of 12 nM. Docosanoic acid has low bioavailability and can increase cholesterol in humans.
    Docosanoic acid
  • HY-B0617S
    S-Adenosyl-L-methionine-d3
    		99.80%
    S-Adenosyl-L-methionine-d3 (S-Adenosyl methionine-d3) is the deuterated product of S-Adenosyl-L-methionine (HY-B0617). S-Adenosyl-L-methionine (S-Adenosyl methionine) is an orally active methyl group donor. S-Adenosyl-L-methionine is a dietary supplement with potent antidepressant effects. S-Adenosyl-L-methionine also has anti‑proliferative, pro‑apoptotic and anti‑metastatic roles in cancers. S-Adenosyl-L-methionine has the potential for, cancer, liver disease and osteoarthritis research.
    S-Adenosyl-L-methionine-d<sub>3</sub>
  • HY-B0303
    Diphenhydramine
    		99.56%
    Diphenhydramine is a first-generation histamine H1-receptor antagonist with anti-cholinergic effect. Diphenhydramine hydrochloride can across the ovine blood-brain barrier (BBB) .
    Diphenhydramine
  • HY-B1008
    4-Aminobenzoic acid
    		99.97%
    4-Aminobenzoic acid is an intermediate in the synthesis of folic acid by bacteria, plants and fungi. 4-Aminobenzoic acid has antibacterial and plant growth regulating properties.
    4-Aminobenzoic acid
  • HY-W035136
    Meso-tetrakis(4-aminophenyl)porphyrin
    		≥98.0%
    Meso-tetrakis(4-aminophenyl)porphyrin (IV) is a porphyrin derivative.
    Meso-tetrakis(4-aminophenyl)porphyrin
  • HY-B0504S
    Creatinine-d3
    		99.90%
    Creatinine-d3 is a deuterium labeled Creatinine. Creatinine is a break-down product of creatine phosphate in muscle.
    Creatinine-d<sub>3</sub>
  • HY-B0528A
    Octopamine hydrochloride
    		99.90%
    Octopamine ((±)-p-Octopamine) hydrochloride, a biogenic monoamine structurally related to noradrenaline, acts as a neurohormone, a neuromodulator and a neurotransmitter in invertebrates. Octopamine hydrochloride can stimulate alpha2-adrenoceptors (ARs) in Chinese hamster ovary cells transfected with human alpha2-ARs. Octopamine hydrochloride increased glycogenolysis, glycolysis, oxygen uptake, gluconeogenesis and the portal perfusion pressure.
    Octopamine hydrochloride
  • HY-P2853
    Hemocyanin
    		98.4%
    Hemocyanin is a large copper-containing respiratory protein. Hemocyanin is an important non-specific innate immune defense molecule with phenoloxidase, antiviral, antibacterial, hemolytic, and antitumor activities.
    Hemocyanin
  • HY-100973
    Adenosine 5′-diphosphoribose
    		98.21%
    Adenosine 5′-diphosphoribose (ADP ribose) is composed of an adenine base attached to a ribose sugar, which is in turn linked to two phosphate groups. Adenosine 5′-diphosphoribose is a key molecule involved in a variety of cellular processes, particularly in the response to DNA damage and the regulation of gene expression.
    Adenosine 5′-diphosphoribose
  • HY-113224
    Desmosterol
    		99.84%
    Desmosterol is a cholesterol-like molecule. In the Bloch pathway of cholesterol biosynthesis, Desmosterol is a direct precursor of cholesterol. As an endogenous metabolite, Desmosterol is used to study cholesterol metabolism . Desmosterol is an LXR activator and SREBP inhibitor, which can suppress macrophage inflammasome activation and prevent vascular inflammation and atherosclerosis. A reduction in Desmosterol promotes the production of mitochondrial reactive oxygen species (ROS) in macrophages and pyrin domain-dependent inflammasome activation of NLRP3. Desmosterol holds potential for research in inflammation, metabolism, and cardiovascular diseases .
    Desmosterol
  • HY-102015
    6-Biopterin
    		99.04%
    6-Biopterin (L-Biopterin), a pterin derivative, is a NO synthase cofactor.
    6-Biopterin
  • HY-113135
    5-Methylcytidine
    		99.72%
    5-Methylcytidine is a nucleoside compound. 5-Methylcytidine has antiviral activity, and its IC50 against HSV-1 is 0.06 μM.
    5-Methylcytidine
  • HY-Y0262
    Oxalic acid, 99%
    		99.56%
    Oxalic Acid is a strong dicarboxylic acid occurring in many plants and vegetables and can be used as an analytical reagent and general reducing agent.
    Oxalic acid, 99%
  • HY-W007926
    2-Oxobutanoic acid
    		99.55%
    2-Oxobutanoic acid is a product in the enzymatic cleavage of cystathionine.
    2-Oxobutanoic acid
  • HY-103638A
    3-Methoxytyramine
    3-Methoxytyramine, a well known extracellular metabolite of 3-hydroxytyramine/dopamine, is a neuromodulator.
    3-Methoxytyramine
  • HY-A0096
    Iloprost
    		99.57%
    Iloprost (ZK 36374; Ciloprost) is a prostacyclin (PGI2) analogue, involves in embryo development and inflammation improvement, and inhibits tumor metastasis. Iloprost can be used for peripheral vascular research.
    Iloprost
Cat. No. Product Name / Synonyms Application Reactivity