2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Endogenous Metabolite

Endogenous Metabolite

Endogenous Metabolite

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Metabolite results when a drug is metabolized into a modified form which continues to produce effects. A metabolome in a given body fluid is influenced by endogenous factors such as age, sex, body composition and genetics as well as underlying pathologies.The levels of the enormous array of unique small-molecule metabolites are usually kept tightly regulated by the activity of a very large array of enzymes and transporters responsible for the production, transformation, degradation, and compartmentalization of these small molecules.The levels of the endogenous small molecules present in the brain are normally tightly regulated.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-79494
    Glyoxalic acid (50% in water)
    Glyoxalic acid (NSC 27785) (50% in water) is an organic compound that is both an aldehyde and a carboxylic acid. Glyoxalic acid (50% in water) induces fluorescence. Glyoxalic acid (50% in water) is used to study neurons.
    Glyoxalic acid (50% in water)
  • HY-N7092
    D-Fructose
    		≥98.0%
    D-Fructose (D(-)-Fructose) is a monosaccharide found in honey, fruits, and other plants. Two D-Fructose molecules can combine to form a disaccharide, sucrose.
    D-Fructose
  • HY-134757
    Lactate oxidase, Microorganism
    Lactate oxidase (EC 1.13.12.4) belongs to a group of FMN-dependent enzymes and they catalyze a conversion of lactate to pyruvate with a release of hydrogen peroxide. Lactate oxidase can be used in the detection of Lactate.
    Lactate oxidase, Microorganism
  • HY-113263
    17a-Hydroxypregnenolone
    		99.61%
    17a-Hydroxypregnenolone is an intermediate in the synthesis of steroid hormones and may be related to the synthesis of sex hormones or adrenal hormones. The sulfate form of 17a-Hydroxypregnenolone (17α-hydroxypregnenolone sulfate) is the main interfering substance in neonatal plasma, which can significantly affect the immunoassay results of 17α-hydroxyprogesterone (17-OHP) by cross-reacting with antibodies.
    17a-Hydroxypregnenolone
  • HY-113332
    Myristoleic acid
    		≥98.0%
    Myristoleic acid, a cytotoxic component in the extract from Serenoa repens, induces apoptosis and necrosis in human prostatic LNCaP cells.
    Myristoleic acid
  • HY-15121
    L-Theanine
    		99.67%
    L-Theanine (L-Glutamic Acid γ-ethyl amide) is a non-protein amino acid contained in green tea leaves, which blocks the binding of L-glutamic acid to glutamate receptors in the brain, and with neuroprotective, anticancer and anti-oxidative activities. L-Theanine can pass through the blood–brain barrier and is orally active.
    L-Theanine
  • HY-135005A
    Biliverdin
    Biliverdin, a tetrapyrrolic pigment, is a product of heme catabolism. Heme is broken down into Biliverdin and carbon monoxide and iron by heme oxidase. Biliverdin is then quickly broken down to bilirubin by Biliverdin reductase. Biliverdin is anti-mutagenic, an antioxidant, anti-inflammatory, and immunosuppressant.
    Biliverdin
  • HY-B0754A
    Hematoporphyrin dihydrochloride
    Hematoporphyrin dihydrochloride (Hematoporphyrin IX dihydrochloride), a photosensitizer, is a substrate for affinity chromatography of heme-binding proteins. Hematoporphyrin dihydrochloride can induce apoptosis in U87 glioma cells and decrease tumor growth in vivo when exposed to red light.
    Hematoporphyrin dihydrochloride
  • HY-111355B
    Cholesteryl sulfate sodium
    		98.22%
    Cholesteryl sulfate sodium is an orally available, NPC2-targeted cholesterol biosynthesis agonist. Cholesteryl sulfate sodium activates SREBP2 by competitively binding to NPC2, promoting cholesterol synthesis (EC50=50 μM). Cholesteryl sulfate sodium enhances the self-assembly ability of Mitoxantrone hydrochloride (HY-13502A), while repairing the intestinal mucosal barrier and inhibiting inflammation by regulating serine protease activity and PKCη signaling pathway. Cholesteryl sulfate sodium is a component of the platelet cell membrane and supports platelet adhesion. Cholesteryl sulfate sodium also regulates the activity of selective protein kinase C isoforms and modulates the specificity of PI3K, playing a role in keratinocyte differentiation.
    Cholesteryl sulfate sodium
  • HY-N2581
    Phytic acid sodium salt
    Phytic acid sodium salt (myo-Inositol; hexakis dihydrogen phosphate; Inositol hexaphosphate) is an orally active compound derived from the seeds of legumes. Phytic acid sodium salt is a [PO4]3- storage depot and precursor for other inositol phosphates and pyrophosphates. phytic acid is hydrolyzed by phytases in a stepwise manner in the plant. Phytic acid sodium salt attenuates Aβ oligomers and upregulates autophagy protein. Phytic acid sodium salt can be used in cardiovascular disease, metabolic disease, nervous system disease and cancer research.
    Phytic acid sodium salt
  • HY-W016814
    (Z)-Aconitic acid
    		99.28%
    (Z)-Aconitic acid is an orally active glutamate decarboxylase inhibitor. (Z)-Aconitic acid reduces IκB-α phosphorylation. (Z)-Aconitic acid inhibits Antigen-induced arthritis and Monosodium urate (HY-B2130A)-induced gout.
    (Z)-Aconitic acid
  • HY-B0172B
    Isolithocholic acid
    		98.70%
    Isolithocholic acid (β-Lithocholic acid) is an isomer of Lithocholic acid. Isolithocholic acid, a bile acid, is formed by microbial metabolism of Lithocholic acid or Lithocholic acid 3α-sulfate.
    Isolithocholic acid
  • HY-N0415
    Trigonelline chloride
    		99.89%
    Trigonelline chloride is an alkaloid with potential antidiabetic activity that can be isolated from Trigonella foenum-graecum L or Leonurus artemisia. Trigonelline chloride is a potent Nrf2 inhibitor that blocks Nrf2-dependent proteasome activity, thereby enhancing apoptosis in pancreatic cancer cells. Trigonelline chloride also has anti-HSV-1, antibacterial, and antifungal activity, and induces ferroptosis.
    Trigonelline chloride
  • HY-B0141A
    Alpha-Estradiol
    		99.88%
    Alpha-Estradiol is a weak estrogen and a 5α-reductase inhibitor which is used as a topical medication in the treatment of androgenic alopecia.
    Alpha-Estradiol
  • HY-120318
    Zeaxanthin
    Zeaxanthin, a diet-obtained carotenoid, presents in the macula region of the eye. Zeaxanthin shows antioxidant effects.
    Zeaxanthin
  • HY-Y1644
    (E)-Crotonic acid
    		99.71%
    NSC 8751 (trans-2-Butenoic acid; trans-Crotonic acid) is an unsaturated carboxylic acid compound containing α,β-unsaturated carboxylic acid groups. NSC 8751 is one of the important analogs for evaluating the safety of fragrance ingredients and is used to evaluate the toxicological properties of compounds with similar structures. When NSC 8751 is applied to local lymph nodes, a 50% concentration does not cause skin sensitization. Structural analogs of NSC 8751 have been shown to be non-genotoxic. trans-Crotonic acid can be used in the preparation of cosmetics and food additives.
    (E)-Crotonic acid
  • HY-18341B
    L-Thyroxine sodium
    		99.75%
    L-Thyroxine sodium (Levothyroxine sodium) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4).
    L-Thyroxine sodium
  • HY-B2132
    Tryptamine
    		99.77%
    Tryptamine is a selective, blood-brain-penetrating 5-HT4 receptor agonist (EC50=1-3 mM) and an endogenous ligand of the aryl hydrocarbon receptor (AHR) (Kd=10-50 nM). Tryptamine promotes intestinal anion secretion and fluid transport by activating G protein-coupled receptors (GPCRs) and accelerates gastrointestinal motility. Tryptamine regulates Th17/Treg balance to inhibit neuroinflammation, competitively binds to 5-HT receptors to regulate central nervous system activity, and participates in temperature regulation and spinal reflex regulation as a neuromodulator. Tryptamine can be used to study intestinal motility disorders such as functional constipation, and has shown significant efficacy in multiple sclerosis models.
    Tryptamine
  • HY-101238
    Agmatine sulfate
    		≥98.0%
    Agmatine sulfate exerts modulatory action at multiple molecular targets, such as neurotransmitter systems, ion channels and nitric oxide synthesis. It is an endogenous agonist at imidazoline receptor and a NO synthase inhibitor.
    Agmatine sulfate
  • HY-113261
    Oleoylcarnitine
    		99.91%
    Oleoylcarnitine, the metabolite which accumulates through suppression of fatty acid β-oxidation, can enhance hepatocarcinogenesis via STAT3 activation.
    Oleoylcarnitine
Cat. No. Product Name / Synonyms Application Reactivity