2. Signaling Pathways
  3. GPCR/G Protein
  4. LPL Receptor
  5. S1PR2 Isoform
  6. S1PR2 Inhibitor

S1PR2 Inhibitor

S1PR2 Inhibitors (2):

Cat. No. Product Name Effect Purity
  • HY-176533
    S1PR5-IN-1
    		Inhibitor
    S1PR5-IN-1 (Compound 7a) is a selective and BBB-penetrable S1PR5 inhibitor with an IC50 of 85.4 nM. S1PR5-IN-1 has a superior binding capacity on S1PR5 with Kds of 2.2, 4.6, and 27.6 nM for recombinant human S1PR5 cell membranes, C57BL/6 mouse brain, and human cerebral cortex, respectively. S1PR5-IN-1 can be used for neurodegenerative disorders like multiple sclerosis research.
  • HY-120409
    AB1
    		Inhibitor
    AB1 is a highly selective S1P2 receptor antagonist (IC50=3.5 nM). AB1 inhibits sphingosine-1-phosphate (S1P) signaling, suppressing tumor cell migration, angiogenesis, and profibrotic mediator CTGF expression while inducing apoptosis. AB1 is promising for research of solid tumors.