2. Signaling Pathways
  3. Cell Cycle/DNA Damage
    Cytoskeleton
  4. Kinesin

Kinesin

Kinesin

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Kinesins are a family of molecular motors that use the energy of ATP hydrolysis to move along the surface of, or destabilize, microtubule filaments. The kinesin motor protein family consists of 14 distinct subclasses and 45 kinesin proteins in humans. A large number of these proteins, or their orthologues, have been shown to possess essential function(s) in both the mitotic and the meiotic cell cycle. Kinesins also can be classified into three groups based on the position of their motor domains: N-terminal, C-terminal and internal kinesins. Conventional kinesin operates as a dimer, walking in a co-ordinated, hand-over-hand fashion along a microtubule protofilament.

Kinesins have important roles in chromosome separation, microtubule dynamics, spindle formation, cytokinesis and cell cycle progression. Roles of kinesins in diseases typically involve defective transport of cell components, transport of pathogens, or cell division.

Kinesin Isoform Specific Products:

Kinesin Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-14846A
    Litronesib Racemate
    		99.20%
    Litronesib Racemate (LY2523355 Racemate) is the racemate of litronesib. Litronesib is a selective, allosteric inhibitor of kinesin Eg5.
    Litronesib Racemate
  • HY-118961
    SR31527 chloride
    		Inhibitor
    SR31527 chloride is a potent KIFC1 inhibitor with an IC50 value of 6.6 µM. SR31527 chloride decreases cell viability and colony formation.
    SR31527 chloride
  • HY-177248A
    Mitotic kinesin-IN-3 hydrochloride
    		Inhibitor
    Mitotic kinesin-IN-3 (Page 135, fourteenth) hydrochloride is a Mitotic kinesin inhibitor. Mitotic kinesin-IN-3 hydrochloride inhibits cell proliferation by suppressing mitosis. Mitotic kinesin-IN-3 hydrochloride can be used for cancer, cardiac hypertrophy, immune and inflammatory disorders, fungal infections research.
    Mitotic kinesin-IN-3 hydrochloride
  • HY-15187B
    Filanesib TFA
    		Inhibitor
    Filanesib TFA (ARRY-520 TFA) is a selective kinesin spindle protein (KSP) inhibitor, with an IC50 of 6 nM for human KSP. Filanesib TFA induces cell death by apoptosis in vitro. Filanesib TFA has potent anti-proliferative activity.
    Filanesib TFA
  • HY-101071
    (S)-Monastrol
    		Inhibitor
    (S)-Monastrol ((+)-Monastrol) is an allosteric inhibitor of the mitotic kinesin Eg5 that exhibits an antiproliferative effect against several cancer cell lines. (S)-Monastrol arrests mammalian cells in mitosis with monopolar spindles.
    (S)-Monastrol
  • HY-14661
    SB-743921 free base
    		Inhibitor
    SB-743921 free base is a potent selective inhibitor of the mitotic kinesin KSP (Eg5), with a Ki of 0.1 nM. SB-743921 free base can induce mitotic arrest, block cell cycle progression, induce apoptosis, and can be used in the research of myeloma, leukemia and other diseases.
    SB-743921 free base
  • HY-115570A
    (Z/E)-GW406108X
    		Inhibitor
    (Z/E)-GW406108X is a mixture of different configurations of GW406108X (HY-115570). GW406108X is a specific Kif15 (Kinesin-12) inhibitor with an IC50 of 0.82 uM.
    (Z/E)-GW406108X
  • HY-146146
    Kolavenic acid analog
    		Inhibitor
    Kolavenic acid analog (KAA) is an anticancer agent. Kolavenic acid analog shows strong activity against HSET-overproducing yeast cells. Kolavenic acid analog inhibits centrosome clustering in human cancer cells containing high HSET levels and supernumerary centrosomes.
    Kolavenic acid analog
  • HY-RS07262
    Kif14 Mouse Pre-designed siRNA Set A
    		Inhibitor

    Kif14 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Kif14 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Kif14 Mouse Pre-designed siRNA Set A
  • HY-N11128
    Solidagonic acid
    		Inhibitor
    Solidagonic acid inhibits HSET motor activity by promoting the conversion from abnormal monopolar to bipolar spindles. Solidagonic acid suppresses fission yeast cell death and enables reversion of the mitotic spindles from a monopolar to bipolar morphology. Solidagonic acid showed the growth inhibitory activity on the seedlings of Lactuca sativa L. and Lolium multiflorum Lam.
    Solidagonic acid
  • HY-155134
    Eg5-IN-1
    		Inhibitor
    Eg5-IN-1 (compound 6c) is a potent kinesin family motor protein (Eg5) inhibitor with an IC50 value of 1.97 µM. Eg5-IN-1 can be used in research of cancer.
    Eg5-IN-1
  • HY-RS07263
    Kif14 Rat Pre-designed siRNA Set A
    		Inhibitor

    Kif14 Rat Pre-designed siRNA Set A contains three designed siRNAs for Kif14 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Kif14 Rat Pre-designed siRNA Set A
  • HY-145827
    KIF18A-IN-4
    		Inhibitor
    KIF18A-IN-4 is a moderately potent ATP and microtubule (MT) noncompetitive KIF18A inhibitor (IC50=6.16 μM). KIF18A-IN-4 has selectivity against a large panel of mitotic kinesins and kinases, and does not show any direct effects on tubulin assembly. KIF18A-IN-4 exhibits anti-tumor activity.
    KIF18A-IN-4
  • HY-177285
    NVP-BQS481
    		Inhibitor
    NVP-BQS481 (Compound 1) is a selective Kinesin spindle protein-5 (Eg5) inhibitor with an IC50< 0.5 nM. NVP-BQS481 has significant antimitotic and antitumor activity (IC50: 0.0.9 nM for SK-OV-3ip cells). NVP-BQS481 can be used as a cytotoxic payload for synthesis of antibody-drug conjugates (ADCs).
    NVP-BQS481
  • HY-177613A
    ALN-12115 sodium
    		Inhibitor
    ALN-12115 sodium is a siRNA that targets kinesin spindle protein (KSP), and it is one of the siRNAs in ALN-VSP.ALN-VSP is a lipid nanoparticle formulation containing two siRNAs for KSP and VEGF with potential antitumor activity.
    ALN-12115 sodium
  • HY-122130
    SCH 2047069
    		Inhibitor
    SCH 2047069 (MK-8267) is an orally active kinesin spindle protein (KSP) inhibitor (Kd: 0.5 nM) that can cross the blood-brain barrier. SCH 2047069 exhibits an IC50 value of ≤ 5 nM against the KSP ATPase. SCH 2047069 exhibits broad-spectrum antitumor activity. SCH 2047069 can induce mitotic arrest and apoptosis in tumor cells. SCH 2047069 can be used in the research of tumors such as ovarian cancer, colon cancer, glioblastoma, and lymphoma.
    SCH 2047069
  • HY-RS07257
    Kif12 Mouse Pre-designed siRNA Set A
    		Inhibitor

    Kif12 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Kif12 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Kif12 Mouse Pre-designed siRNA Set A
  • HY-158683
    KIF18A-IN-11
    		Inhibitor
    KIF18A-IN-11 (Compound 13) is a potent KIF18A inhibitor, with IC50 values of less than 100 nM in OVCAR3 and MDA-MB-157 cells. KIF18A-IN-11 can be used for the research of cancer.
    KIF18A-IN-11
  • HY-RS07255
    KIF11 Human Pre-designed siRNA Set A
    		Inhibitor

    KIF11 Human Pre-designed siRNA Set A contains three designed siRNAs for KIF11 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    KIF11 Human Pre-designed siRNA Set A
  • HY-RS07258
    Kif12 Rat Pre-designed siRNA Set A
    		Inhibitor

    Kif12 Rat Pre-designed siRNA Set A contains three designed siRNAs for Kif12 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Kif12 Rat Pre-designed siRNA Set A
Cat. No. Product Name / Synonyms Application Reactivity
Kinesin Isoform Comparison

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