2. Signaling Pathways
  3. Cell Cycle/DNA Damage
    Cytoskeleton
  4. Kinesin

Kinesin

Kinesin

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Kinesins are a family of molecular motors that use the energy of ATP hydrolysis to move along the surface of, or destabilize, microtubule filaments. The kinesin motor protein family consists of 14 distinct subclasses and 45 kinesin proteins in humans. A large number of these proteins, or their orthologues, have been shown to possess essential function(s) in both the mitotic and the meiotic cell cycle. Kinesins also can be classified into three groups based on the position of their motor domains: N-terminal, C-terminal and internal kinesins. Conventional kinesin operates as a dimer, walking in a co-ordinated, hand-over-hand fashion along a microtubule protofilament.

Kinesins have important roles in chromosome separation, microtubule dynamics, spindle formation, cytokinesis and cell cycle progression. Roles of kinesins in diseases typically involve defective transport of cell components, transport of pathogens, or cell division.

Kinesin Isoform Specific Products:

Kinesin Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-118961
    SR31527 chloride
    		Inhibitor
    SR31527 chloride is a potent KIFC1 inhibitor with an IC50 value of 6.6 µM. SR31527 chloride decreases cell viability and colony formation.
    SR31527 chloride
  • HY-15187B
    Filanesib TFA
    		Inhibitor
    Filanesib TFA (ARRY-520 TFA) is a selective kinesin spindle protein (KSP) inhibitor, with an IC50 of 6 nM for human KSP. Filanesib TFA induces cell death by apoptosis in vitro. Filanesib TFA has potent anti-proliferative activity.
    Filanesib TFA
  • HY-101071
    (S)-Monastrol
    		Inhibitor
    (S)-Monastrol ((+)-Monastrol) is an allosteric inhibitor of the mitotic kinesin Eg5 that exhibits an antiproliferative effect against several cancer cell lines. (S)-Monastrol arrests mammalian cells in mitosis with monopolar spindles.
    (S)-Monastrol
  • HY-14661
    SB-743921 free base
    		Inhibitor
    SB-743921 free base is a potent selective inhibitor of the mitotic kinesin KSP (Eg5), with a Ki of 0.1 nM. SB-743921 free base can induce mitotic arrest, block cell cycle progression, induce apoptosis, and can be used in the research of myeloma, leukemia and other diseases.
    SB-743921 free base
  • HY-115570A
    (Z/E)-GW406108X
    		Inhibitor
    (Z/E)-GW406108X is a mixture of different configurations of GW406108X (HY-115570). GW406108X is a specific Kif15 (Kinesin-12) inhibitor with an IC50 of 0.82 uM.
    (Z/E)-GW406108X
  • HY-146146
    Kolavenic acid analog
    		Inhibitor
    Kolavenic acid analog (KAA) is an anticancer agent. Kolavenic acid analog shows strong activity against HSET-overproducing yeast cells. Kolavenic acid analog inhibits centrosome clustering in human cancer cells containing high HSET levels and supernumerary centrosomes.
    Kolavenic acid analog
  • HY-RS07262
    Kif14 Mouse Pre-designed siRNA Set A
    		Inhibitor

    Kif14 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Kif14 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Kif14 Mouse Pre-designed siRNA Set A
    Kif14 Mouse Pre-designed siRNA Set A
  • HY-N11128
    Solidagonic acid
    		Inhibitor
    Solidagonic acid inhibits HSET motor activity by promoting the conversion from abnormal monopolar to bipolar spindles. Solidagonic acid suppresses fission yeast cell death and enables reversion of the mitotic spindles from a monopolar to bipolar morphology. Solidagonic acid showed the growth inhibitory activity on the seedlings of Lactuca sativa L. and Lolium multiflorum Lam.
    Solidagonic acid
  • HY-155134
    Eg5-IN-1
    		Inhibitor
    Eg5-IN-1 (compound 6c) is a potent kinesin family motor protein (Eg5) inhibitor with an IC50 value of 1.97 µM. Eg5-IN-1 can be used in research of cancer.
    Eg5-IN-1
  • HY-RS07263
    Kif14 Rat Pre-designed siRNA Set A
    		Inhibitor

    Kif14 Rat Pre-designed siRNA Set A contains three designed siRNAs for Kif14 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Kif14 Rat Pre-designed siRNA Set A
    Kif14 Rat Pre-designed siRNA Set A
  • HY-162937
    KIF18A-IN-13
    		Inhibitor
    KIF18A-IN-13 (Compound 16) is an effective and orally active inhibitor of KIF18A with anticancer activity in vivo. KIF18A-IN-13 can be utilized for research in ovarian cancer.
    KIF18A-IN-13
  • HY-145827
    KIF18A-IN-4
    		Inhibitor
    KIF18A-IN-4 is a moderately potent ATP and microtubule (MT) noncompetitive KIF18A inhibitor (IC50=6.16 μM). KIF18A-IN-4 has selectivity against a large panel of mitotic kinesins and kinases, and does not show any direct effects on tubulin assembly. KIF18A-IN-4 exhibits anti-tumor activity.
    KIF18A-IN-4
  • HY-RS07257
    Kif12 Mouse Pre-designed siRNA Set A
    		Inhibitor

    Kif12 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Kif12 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Kif12 Mouse Pre-designed siRNA Set A
    Kif12 Mouse Pre-designed siRNA Set A
  • HY-158683
    KIF18A-IN-11
    		Inhibitor
    KIF18A-IN-11 (Compound 13) is a potent KIF18A inhibitor, with IC50 values of less than 100 nM in OVCAR3 and MDA-MB-157 cells. KIF18A-IN-11 can be used for the research of cancer.
    KIF18A-IN-11
  • HY-RS07255
    KIF11 Human Pre-designed siRNA Set A
    		Inhibitor

    KIF11 Human Pre-designed siRNA Set A contains three designed siRNAs for KIF11 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    KIF11 Human Pre-designed siRNA Set A
    KIF11 Human Pre-designed siRNA Set A
  • HY-RS07258
    Kif12 Rat Pre-designed siRNA Set A
    		Inhibitor

    Kif12 Rat Pre-designed siRNA Set A contains three designed siRNAs for Kif12 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Kif12 Rat Pre-designed siRNA Set A
    Kif12 Rat Pre-designed siRNA Set A
  • HY-RS07256
    KIF12 Human Pre-designed siRNA Set A
    		Inhibitor

    KIF12 Human Pre-designed siRNA Set A contains three designed siRNAs for KIF12 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    KIF12 Human Pre-designed siRNA Set A
    KIF12 Human Pre-designed siRNA Set A
  • HY-15187C
    Filanesib hydrochloride
    		Inhibitor
    Filanesib (ARRY-520) hydrochloride is a selective and noncompetitive kinesin spindle protein (KSP) inhibitor, with an IC50 of 6 nM for human KSP. Filanesib induces cell death by apoptosis in vitro. Filanesib has potent anti-proliferative activity.
    Filanesib hydrochloride
  • HY-161112
    LG157
    		Inhibitor
    LG157 is a potent inhibitor of mitotic kinesin-like protein 2 (MKLP2).
    LG157
  • HY-162292
    Anticancer agent 190
    		Inhibitor
    Anticancer agent 190 (compound 3e) is an inhibitor targeting KSP (Kinesin) and PI3Kδ with activity against breast cancer.
    Anticancer agent 190
Cat. No. Product Name / Synonyms Application Reactivity
Kinesin Isoform Comparison

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