2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Glucokinase

Glucokinase

Hexokinase IV; Hexokinase D

Glucokinase

Related Products

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Glucokinase is an enzyme that facilitates phosphorylation of glucose to glucose-6-phosphate. Glucokinase occurs in cells in theliver, pancreas, gut, and brain of humans and most other vertebrates. In each of these organs it plays an important role in the regulation of carbohydrate metabolism by acting as a glucose sensor, triggering shifts in metabolism or cell function in response to rising or falling levels of glucose, such as occur after a meal or when fasting. Glucokinase has a lower affinity for glucose than the other hexokinases do, and its activity is localized to a few cell types, leaving the other three hexokinases as more important preparers of glucose for glycolysis and glycogen synthesis for most tissues and organs. Mutations of the gene for this enzyme can cause unusual forms of diabetes or hypoglycemia.

Glucokinase Related Products (38):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-144287
    Glucokinase activator 3
    		Activator 98.36%
    Glucokinase activator 3 is a potent and full Glucokinase (GK) activator with an AC50 of 38 nM. Glucokinase activator 3 has the potential for the research of type 2 diabetes.
    Glucokinase activator 3
  • HY-117721
    IHVR-11029
    		Inhibitor 99.86%
    IHVR-11029 is a small molecule inhibitor of ER α-glucosidases, with an EC50 of 0.09 μM.
    IHVR-11029
  • HY-19843A
    MK-0941 free base
    		Activator
    MK-0941 free base is an orally active glucokinase activator, with EC50s of 240 and 65 nM for recombinant human glucokinase in the presence of 2.5 and 10 mM glucose, respectively. MK-0941 free base exhibits strong glucose-lowering activity and is a potential therapeutic agent for treatment of type 2 diabetes.
    MK-0941 free base
  • HY-133127A
    AR453588 hydrochloride
    		Activator
    AR453588 hydrochloride is a potent and orally bioavailable anti-diabetic glucokinase activator, with an EC50 of 42 nM. AR453588 hydrochloride shows anti-hyperglycemic activity.
    AR453588 hydrochloride
  • HY-101788
    Glucokinase activator 1
    		Activator
    Glucokinase activator 1 is a liver-directed glucokinase activator with an EC50 of 34 nM.
    Glucokinase activator 1
  • HY-116946
    Glucokinase activator 6
    		Activator
    Glucokinase activator 6 (compound 9) is a potent glucokinase activator, with an EC50 of 0.09 μM. Glucokinase activator 6 can be used for type 2 diabetes (T2D) research.
    Glucokinase activator 6
  • HY-117603
    CM-10-18
    		Inhibitor
    CM-10-18 is a potent and orally active inhibitor of both α-glucosidases I and II in vitro and in treated animals. CM-10-18 inhibits DENV infection of cultured human cells and reduces the peak viremia of DENV in mice.
    CM-10-18
  • HY-P3257B
    ADP-Specific glucokinase, thermococcus litoralis
    ADP-Specific glucokinase, thermococcus litoralis is an ADP-specific glucose kinase expressed in thermophilic archaea. ADP-Specific glucokinase, thermococcus litoralis can catalyze glucose into glucose-6-phosphate, which promotes glycolysis. ADP-Specific glucokinase, thermococcus litoralis can activate T cells and enhance the phagocytic activity of macrophages. ADP-Specific glucokinase, thermococcus litoralis can be used in research on metabolic diseases, neurological disorders, and tumors.
    ADP-Specific glucokinase, thermococcus litoralis
  • HY-P3257A
    ADP-specific glucokinase, pyrococcus furiosus
    ADP-Specific glucokinase, pyrococcus furiosus is an ADP-specific glucose kinase expressed in thermophilic archaea. ADP-Specific glucokinase, pyrococcus furiosus can catalyze glucose into glucose-6-phosphate, which promotes glycolysis. ADP-Specific glucokinase, pyrococcus furiosus can activate T cells and enhance the phagocytic activity of macrophages. ADP-Specific glucokinase, pyrococcus furiosus can be used in research on metabolic diseases, neurological disorders, and tumors.
    ADP-specific glucokinase, pyrococcus furiosus
  • HY-121070
    AZD1092
    		Activator
    AZD1092 is an orally active glucokinase (GK) activator with an EC50 value of 0.03 μM. AZD1092 can be used for the research of Type 2 Diabetes (T2D).
    AZD1092
  • HY-136631
    PF-04279405
    		Agonist
    PF-04279405 is a potent and full-acting glucokinase (GK) agonist (EC50=23 nM). Glucokinase (GK) is an enzyme responsible for the conversion of glucose to glucose-6-phosphate and plays a key role in maintaining blood glucose homeostasis. PF-04279405 can be used in the research of type 2 diabetes.
    PF-04279405
  • HY-14747
    Piragliatin
    		Activator
    Piragliatin (RO4389620) is an activator for glucokinase, which reduces endogenous glucose production, increases β-cell function and glucose utilization, and thus decreases the blood glucose levels. Piragliatin exhibits antidiabetic efficacy.
    Piragliatin
  • HY-109030R
    Dorzagliatin (Standard)
    		Activator
    Dorzagliatin (Standard) is the analytical standard of Dorzagliatin. This product is intended for research and analytical applications. Dorzagliatin (HMS5552), a dual-acting glucokinase (GK) activator, improves glycaemic control and pancreatic β-cell function in type 2 diabetes.
    Dorzagliatin (Standard)
  • HY-119813
    (S,S)-Sinogliatin
    		Activator
    (S,S)-Sinogliatin ((S,S)-HMS-5552) is the (S,S) -enantiomer of Sinogliatin. Sinogliatin is a glucokinase activator that can be used to study type 2 diabetes.
    (S,S)-Sinogliatin
  • HY-169545
    Glucokinase activator 8
    		Activator
    Glucokinase activator 8 is an activator for glucokinase.
    Glucokinase activator 8
  • HY-116682
    GKA-71
    		Activator
    GKA-71 is an orally active Glucokinase activator, possesses an islet protective effect.
    GKA-71
  • HY-156923
    Glucokinase activator 5
    		Activator
    Glucokinase activator 5 (compound 6) is a glucokinase activator.
    Glucokinase activator 5
  • HY-U00411
    PSN-GK1
    		Activator
    PSN-GK1 is a potent glucokinase activator with an EC50 of 0.13 μM.
    PSN-GK1