2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-107492
    Ethaboxam
    		Inhibitor
    Ethaboxam is a β-tubulin inhibitor that can be used as anti-oomycete fungicide.
    Ethaboxam
  • HY-N15444
    Bullatenone
    		Inhibitor
    Bullatenone is a volatile bioactive compound that can be found in Lophomyrtus bullata. It has insect - repellent, anti - ulcer, anti - UV, and antifungal activities. Bullatenone can inhibit the growth of fungi such as Candida albicans and Cladosporium resinae. Bullatenone can be used in the research of diseases such as inflammation and infections.
    Bullatenone
  • HY-W753375
    Fluindapyr
    		Inhibitor ≥98.0%
    Fluindapyr is a broad-spectrum pyrazolamide chiral fungicide of succinate dehydrogenase inhibitor (SDHIs) with broad bactericidal spectrum and good efficacy. Fluopimomide is effective against M. incognita in vitro and application of fuopimomide shows some growth promotion effect in cucumber.
    Fluindapyr
  • HY-N14803
    Nanaomycin B
    		Inhibitor
    Nanaomycin B is an antibiotic. Nanaomycin B has anti-Gram-positive bacteria, mycobacteria, mycoplasma and fungi activity.
    Nanaomycin B
  • HY-165123
    Mepartricin
    		Inhibitor
    Mepartricin is a polyene macrolide with antifungal and antiprotozoal activities, widely used in research related to benign prostatic hyperplasia.
    Mepartricin
  • HY-N13908
    Acremonol
    		Inhibitor
    Acremonol has anti-Gram-positive bacteria and fungal activity.
    Acremonol
  • HY-N14283
    Ezomycin D2
    		Inhibitor
    Ezomycin D2 is an antifungal antibiotic. Ezomycin D2 is mainly active against phytopathogens such as Sclerotinia sclerotiorum and Botrytis, and has a control effect on Sclerotinia, Botrytis and Candidiasis of crops.
    Ezomycin D2
  • HY-148223
    Tolindate
    		Inhibitor
    Tolindate is a potent PXR agonist with an EC50 value of 8.3 μM. Tolindate shows antifungal activity.
    Tolindate
  • HY-136758
    CYP51-IN-8
    		Inhibitor
    CYP51-IN-2 (compound 1h), a Fluconazole (HY-B0101) analog, is a potent antifungal agent. CYP51-IN-2 shows MIC80s of 15.6 and 62.5 ng/mL for Microsporum gypseum and Candida albicans, respectively.
    CYP51-IN-8
  • HY-163631
    Antibacterial agent 218
    		Inhibitor
    Antibacterial agent 218 (compound d28) is an orally active sterol 24-C-Methyltransferase inhibitor with the IC50 of 0.273 μM. Antibacterial agent 218 shows antifungal activity against the C.albicans SC5314 with the IC50 of 0.25 μg/mL.
    Antibacterial agent 218
  • HY-N13151
    3-GlcA-28-AraRhaxyl-medicagenate
    		Inhibitor
    3-GlcA-28-AraRhaxyl-medicagenate is an insect toxin belonging to the saponin family. 3-GlcA-28-AraRhaxyl-medicagenate exhibits antifungal activity and causes mortality in rice weevils at doses down to 0.1 mg/mL.
    3-GlcA-28-AraRhaxyl-medicagenate
  • HY-N14812
    Neobulgarone E
    		Inhibitor
    Neobulgarone E is an anthraquinone derivative of Neobulgaria pura HA A07-97, a fungus of the ascomycetes class. Neobulgarone E can inhibit the formation of Appressorium in Magnaporthe grisea and has weak cytotoxicity without antifungal, antibacterial or phytotoxicity.
    Neobulgarone E
  • HY-117424
    Inz-4
    		Inhibitor
    Inz-4 is a fungal-selective inhibitor of mitochondrial cytochrome bc1, with the IC50 of 0.026 μM.
    Inz-4
  • HY-B1843R
    Fuberidazole (Standard)
    		Inhibitor
    Fuberidazole (Standard) is the analytical standard of Fuberidazole. This product is intended for research and analytical applications. Fuberidazole (BAY 33172; Furidazole) is a fungicide. Fuberidazole shows a synergistic effect with cucurbituril (CB) macromolecules, such as CB7 and CB8. Studies have shown that, CB8 induces pKa shifts on Fuberidazole. Fuberidazole significantly inhibits the growth of B. cinerea.
    Fuberidazole (Standard)
  • HY-119683S1
    Epoxiconazole-d4
    		Inhibitor
    Epoxiconazole-d4 is the deuterium labeled Epoxiconazole (HY-119683). Epoxiconazole, a fungicide, is a demethylation inhibitor of the Ergosterol biosynthesis pathway. Epoxiconazole exhibits strong inhibitory effects on both carbendazim-resistant and phenamacril-resistant isolates, and can be used for controlling many crop diseases.
    Epoxiconazole-d<sub>4</sub>
  • HY-114717
    Pterophyllin 2
    		Inhibitor
    Pterophyllin 2 is a fungicide against R. stolonifer with a MFC value of 250 μg/mL. Pterophyllin 2 also has antifungal activity against B. cinerea and M. fructicola.
    Pterophyllin 2
  • HY-N14488
    Nemotinic acid
    		Inhibitor
    Nemotinic acid has the activity against Gram-positive bacteria, mycobacterium and fungus, and also against Gram-negative bacteria, but the activity is weak.
    Nemotinic acid
  • HY-115441
    (Rac)-Luliconazole
    		Inhibitor
    (Rac)-Luliconazole ((Rac)-NND 502) is the racemic isomer of Luliconazole (HY-14283). Luliconazole is a topical antifungal imidazole antibiotic with broad-spectrum and potent antifungal activity.
    (Rac)-Luliconazole
  • HY-B1211R
    Dehydroacetic acid (Standard)
    		Inhibitor
    Dehydroacetic acid (Standard) (Biocide 470F (Standard)) is the analytical standard of Dehydroacetic acid (HY-B1211). This product is intended for research and analytical applications. Dehydroacetic acid (Biocide 470F) is a pyrone derivative. Dehydroacetic acid has antibacterial, antifungal and phytotoxic activities. Dehydroacetic acid can be added to cosmetics, food and beverages for preservation and other purposes. Dehydroacetic acid can also be used to synthesize various heterocycles and cycloaddition products.
    Dehydroacetic acid (Standard)
  • HY-B0101R
    Fluconazole (Standard)
    		Inhibitor
    Fluconazole (Standard) is the analytical standard of Fluconazole. This product is intended for research and analytical applications. Fluconazole (UK-49858) is a triazole antifungal agent with excellent activities against a broad range of fungi, especially against Candida albicans. Fluconazole inhibits C. albicans and Candida kefyr with IC99s range from 0.20 μg/mL to 0.39 μg/mL.
    Fluconazole (Standard)
Cat. No. Product Name / Synonyms Application Reactivity