2,5-Furandimethanol

Cat. No.: HY-W017782 Purity: 99.01%: Data Sheet
COA

SDS
Handling Instructions
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2,5-Furandimethanol (2,5-Bis(hydroxymethyl)furan) is a building block for the enzymatic synthesis of bio-based polyesters. 2,5-Furandimethanol is also a metabolite of Phellinus linteus. 2,5-Furandimethanol affects leukemia. 2,5-Furandimethanol can be used in fungal infection research.

For research use only. We do not sell to patients.

2,5-Furandimethanol Chemical Structure

CAS No. : 1883-75-6

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
500 mg	In-stock	Estimated Time of Arrival: December 31
1 g	In-stock	Estimated Time of Arrival: December 31
5 g	In-stock	Estimated Time of Arrival: December 31
10 g	In-stock	Estimated Time of Arrival: December 31
25 g	In-stock	Estimated Time of Arrival: December 31
50 g	In-stock	Estimated Time of Arrival: December 31
100 g	In-stock	Estimated Time of Arrival: December 31
> 100 g	Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]^[2]

Fungal Metabolite

In Vitro

2,5-Furandimethanol exhibits an MIC of >100 μg/mL in the Nadsonia fulvescens resistance test^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

128.13

Formula

C₆H₈O₃

CAS No.

1883-75-6

Appearance

Solid

Color

Light yellow to yellow

SMILES

OCC1=CC=C(CO)O1

Structure Classification

Others

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (780.46 mM; Need ultrasonic)

DMSO : 50 mg/mL (390.23 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	7.8046 mL	39.0229 mL	78.0457 mL
5 mM	1.5609 mL	7.8046 mL	15.6091 mL
10 mM	0.7805 mL	3.9023 mL	7.8046 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (19.51 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (19.51 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (19.51 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.62%

Select Batch:

Data Sheet (283 KB) SDS (393 KB)

COA (245 KB) HNMR (127 KB) GC (213 KB)

Handling Instructions (2659 KB)

References

[1]. Schneider G, et al. Xylaramide, a new antifungal compound, and other secondary metabolites from Xylaria longipes. Z Naturforsch C J Biosci. 1996 Nov-Dec;51(11-12):802-6. [Content Brief]

[2]. Jiang Y, et al. Enzymatic synthesis of biobased polyesters using 2,5-bis(hydroxymethyl)furan as the building block. Biomacromolecules. 2014 Jul 14;15(7):2482-93. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	7.8046 mL	39.0229 mL	78.0457 mL	195.1143 mL
	5 mM	1.5609 mL	7.8046 mL	15.6091 mL	39.0229 mL
	10 mM	0.7805 mL	3.9023 mL	7.8046 mL	19.5114 mL
	15 mM	0.5203 mL	2.6015 mL	5.2030 mL	13.0076 mL
	20 mM	0.3902 mL	1.9511 mL	3.9023 mL	9.7557 mL
	25 mM	0.3122 mL	1.5609 mL	3.1218 mL	7.8046 mL
	30 mM	0.2602 mL	1.3008 mL	2.6015 mL	6.5038 mL
	40 mM	0.1951 mL	0.9756 mL	1.9511 mL	4.8779 mL
	50 mM	0.1561 mL	0.7805 mL	1.5609 mL	3.9023 mL
	60 mM	0.1301 mL	0.6504 mL	1.3008 mL	3.2519 mL
	80 mM	0.0976 mL	0.4878 mL	0.9756 mL	2.4389 mL
	100 mM	0.0780 mL	0.3902 mL	0.7805 mL	1.9511 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.