2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-106542AR
    Eberconazole nitrate (Standard)
    Eberconazole nitrate (Standard) is the analytical standard of Eberconazole nitrate. This product is intended for research and analytical applications. Eberconazole nitrate is a dichlorinated imidazole derivative with antifungal activity. Eberconazole nitrate is more effective than Clotrimazole (HY-10882), Ketoconazole (HY-B0105), and Miconazole (HY-B0454). Eberconazole nitrate has potential for the study of dermatophytosis.
    Eberconazole nitrate (Standard)
  • HY-N14550
    Cyclogregatin
    		Inhibitor
    Cyclogregatin has anti-bacterial and fungal activity. Cyclogregatin inhibits airy ascites carcinoma with a MIC of 10 μg/mL .
    Cyclogregatin
  • HY-128429R
    Trans-​2-​Hexenal (Standard)
    		Inhibitor
    Trans-​2-​Hexenal (Standard) is the analytical standard of Trans-​2-​Hexenal. This product is intended for research and analytical applications. Trans-​2-​Hexenal can be used for the determination of low-molecular-weight carbonyl compounds which are reactive with biological nucleophiles in biological samples.
    Trans-​2-​Hexenal (Standard)
  • HY-P9962
    Efungumab
    		Inhibitor
    Efungumab is a monoclonal antibody with antifungal activity. Efungumab binds to HSP 90, preventing a conformational change needed for fungal viability. Efungumab can be used for research on invasive candidiasis (IC).
    Efungumab
  • HY-W712392
    Polyoxin D zinc
    		Inhibitor
    Polyoxin D (zinc) (Polyoxorim (zinc)), a polyoxin antibiotic fungicide, is a potent chitin synthetase inhibitor.
    Polyoxin D zinc
  • HY-N14544
    Orchinol
    		Inhibitor
    Orchinol is an aromatic derivative of antibiotic and has antifungal activity.
    Orchinol
  • HY-W979008
    (+)-Isopinocampheol
    		Inhibitor
    (+)-Isopinocampheol is an oxygenated monoterpenoid that is important in the chemical ecology of bark beetles.
    (+)-Isopinocampheol
  • HY-119898
    Alloocimene
    		Inhibitor
    Alloocimene is a diterpenoid that activates defense genes and induces resistance to Botrytis cinerea in Arabidopsis thaliana.
    Alloocimene
  • HY-126602
    Kinamycin B
    		Inhibitor
    Kinamycin B is an antibiotic found in Streptomyces murayamaensis of the genus Streptomyces that exhibits antifungal activity.
    Kinamycin B
  • HY-N14435
    Pradimicin Q
    		Inhibitor
    Pradimicin Q is an antibiotic. The cytotoxicity (IC50) to human colon HCT-116 cells and murine melanoma B16-F10 cells are 75 and 100 μg/mL, respectively.
    Pradimicin Q
  • HY-14283S1
    Luliconazole-d3
    		Inhibitor
    Luliconazole-d3 (NND 502-d3) is deuterium labeled Luliconazole. Luliconazole (NND 502)?is a topical antifungal imidazole antibiotic with broad-spectrum and potent antifungal activity. Luliconazole can be used for the research of skin infection, including?dermatophytosis, tinea corporis, tinea pedis?et al.
    Luliconazole-d<sub>3</sub>
  • HY-59097
    (E/Z)-Tapinarof
    		Inhibitor
    (E/Z)-Tapinarof ((E/Z)-WBI-1001; 3,5-dihydroxy-4-isopropylstilbene) is a broad-spectrum antibiotic. (E/Z)-Tapinarof has anti-bacterial, anti-fungal and anti-nematode activities.
    (E/Z)-Tapinarof
  • HY-N14044
    Crocacin D
    		Inhibitor
    Crocacin D has anti-yeast and filamentous fungal activity. Crocacin D can inhibit mouse fibroblasts L929. In the microsomes of the calf's heart, Crocacin D can interrupt the bc1 segment of electronic transmission, causes redshift of 569 nm peak in cytochrome B reduction spectrum.
    Crocacin D
  • HY-N14269
    Ezomycin A2
    		Inhibitor
    Ezomycin A2 is an antifungal antibiotic. Ezomycin A2 is mainly active against phytopathogens such as Sclerotinia sclerotiorum and Botrytis, and has a control effect on Sclerotinia, Botrytis and Candidiasis of crops.
    Ezomycin A2
  • HY-119459R
    Fluopyram (Standard)
    		Inhibitor
    Fluopyram (Standard) is the analytical standard of Fluopyram (HY-119459). This product is intended for research and analytical applications. Fluopyram is an orally active succinate dehydrogenase inhibitor, antifungal and nematicide. Fluopyram inhibits succinate dehydrogenase activity, activates CAR/PXR nuclear receptors, and increases caspase-3, TNF-α and NF-κB. Fluopyram inhibits the growth of F. virguliforme, Botrytis cinerea and Alternaria solani with EC50 values of 3.35, 5.389 and 0.244 µg/mL, respectively. Fluopyram induces liver and thyroid tumor formation. Fluopyram is nephrotoxic and embryotoxic.
    Fluopyram (Standard)
  • HY-N15056
    Chainin
    		Inhibitor
    Chainin has anti-yeast and Aspergillus Niger fungal activity.
    Chainin
  • HY-163891
    Antifungal agent 107
    		Inhibitor
    Antifungal agent 107 (compound b24) is an OSBP inhibitor with antifungal activity. Antifungal agent 107 can be used to control cucumber downy mildew and potato late blight in greenhouse.
    Antifungal agent 107
  • HY-B2033S1
    Pyrimethanil-d5
    		≥99.0%
    Pyrimethanil-d5 is the deuterium labeled Pyrimethanil (HY-B2033). Pyrimethanil is an anilinopyrimidine and broad-spectrum contact fungicide for the control of Botrytis spp. on a wide variety of crops. Pyrimethanil inhibits the biosynthesis of methionine and other amino acids in Botrytis cinerea. Pyrimethanil can be used for the research of fungal diseases prevention on fruit, vegetable and ornamental plants with mold infection.
    Pyrimethanil-d<sub>5</sub>
  • HY-113863
    Rilopirox
    		Inhibitor
    Rilopirox (HOE 351) is a hydroxy-pyridone compound with antimycotic properties. Rilopirox, a chelating agent, can inhibit catalase. Rilopirox inhibits the respiratory chain. Rilopirox inhibits growth of yeast isolates with a MIC50 of 4 μg/mL. Rilopirox has the potential for vaginal candidosis and oropharyngeal Candida infections research.
    Rilopirox
  • HY-N15288
    Cavipetin C
    		Inhibitor
    Cavipetin C is a diterpene that can be isolated from B. cavipes. Cavipetin C exhibits antifungal activity that blocks the Cladosporium cucumericum spore formation.
    Cavipetin C
Cat. No. Product Name / Synonyms Application Reactivity