2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N15184
    Benanomicin B
    		Inhibitor
    Benanomicin B (Pradimicin C) is an antifungal antibiotic that also has antibacterial activity against two Gram-positive bacteria: Micrococcus luteus and Corynebacterium bovis.
    Benanomicin B
  • HY-W701251
    Ethylparaben-d5
    		Inhibitor
    Ethylparaben-d5 (Ethyl parahydroxybenzoate-d5) is deuterium labeled Ethylparaben. Ethylparaben is the ethyl ester of paraben and is used as an antifungal preservative and food additive.
    Ethylparaben-d<sub>5</sub>
  • HY-N13997
    Clavamycin C
    		Inhibitor
    Clavamycin C has strong anti-candida activity, and its action can be antagonized by dipeptide or tripeptide, but amino acid can not cancel its action. No antibacterial activity and no inhibition of β-lactamase.
    Clavamycin C
  • HY-16246R
    Haloprogin (Standard)
    		Inhibitor
    Haloprogin (Standard) is the analytical standard of Haloprogin. This product is intended for research and analytical applications. Haloprogin is a potent antifungal agent. Haloprogin has activity against dermatophytes, Candida spp and a limited number of Gram-positive bacteria.
    Haloprogin (Standard)
  • HY-N0626R
    Sorbic acid (Standard)
    		Inhibitor
    Sorbic acid (Standard) is the analytical standard of Sorbic acid. This product is intended for research and analytical applications. Sorbic acid is a highly efficient, and nonpoisonous?food preservative.?Sorbic acid generally is an effective inhibitor of most molds and yeasts and some bacteria.
    Sorbic acid (Standard)
  • HY-W020777R
    Triflumizole (Standard)
    		Inhibitor
    Triflumizole (Standard) is the analytical standard of Triflumizole. This product is intended for research and analytical applications. Triflumizole is one of imidazole fungicides that works by inhibiting ergosterol biosynthesis, and is widely used for the control of powdery mildew and scabs on various fruits and crops.
    Triflumizole (Standard)
  • HY-N13995
    Serratamolide
    		Inhibitor
    Serratamolide is a depsipeptide antibiotic. Serratamolide has anti-Gram-positive bacteria, mycobacteria and fungi activity, but the activity is weak.
    Serratamolide
  • HY-W089091
    Cispentacin
    		Inhibitor
    Cispentacin has anti-candida and other fungi activity, and has no toxicity at 1g/kg.
    Cispentacin
  • HY-129548A
    Prumycin di(hydrochloride)
    		Inhibitor
    Prumycin dihydrochloride is an antifungal antibiotic with activity against cucumber powdery mildew. Prumycin dihydrochloride significantly inhibited the disease, whereas other metabolites such as bacillomycin D and surfactin did not. Prumycin dihydrochloride did not induce the expression of plant defense genes, indicating that its effects were not through plant defense responses. Observation of cucumber cotyledons treated with prumycin showed that it could inhibit spore germination of P. fusca.
    Prumycin di(hydrochloride)
  • HY-159666
    Nystatin A1
    		Inhibitor
    Nystatin A1 is a polyene macrolide antifungal antibiotic that can be isolated from Streptomyces noursei. Nystatin A1 binds to ergosterol on the fungal cell membrane, increasing the permeability of the cell membrane and causing leakage of cell contents, thereby inhibiting the growth and reproduction of fungi.
    Nystatin A1
  • HY-N12913
    Antibiotic WB
    		Inhibitor
    Antibiotic WB is an antibioticwith antifungal activity and can be isolated from the soil fungus strain 38.
    Antibiotic WB
  • HY-136384R
    Diethofencarb (Standard)
    		Inhibitor
    Diethofencarb (Standard) is the analytical standard of Diethofencarb. This product is intended for research and analytical applications. Diethofencarb is a fungicide with strong activity against Botrytis cinerea and Benzimidazole-resistant strains of Botryis spp. Diethofencarb has a role as an antifungal agrochemical.
    Diethofencarb (Standard)
  • HY-N13892
    Alisamycin
    		Inhibitor
    Alisamycin is the manumycin group of antibiotic. Alisamycin is active against Gram-positive bacteria and fungi, and has a weak antitumour activity.
    Alisamycin
  • HY-W422288
    (Rac)-Ketoconazole
    (Rac)-Ketoconazole ((Rac)-R 41400) is an antifungal imidazole compound with oral activity. (Rac)-Ketoconazole interferes with ergosterol synthesis by inhibiting cytochrome P450-dependent 14α-sterol demethylase (CYP51), a key enzyme on the fungal cell membrane, leading to membrane dysfunction and ultimately inhibition of fungal growth and reproduction. (Rac)-Ketoconazole is indicated for studies of fungal infections.
    (Rac)-Ketoconazole
  • HY-N9720
    Herbarin
    		Inhibitor
    Herbarin is a quinone antibiotic. Herbarin complex has anti-Gram-positive bacteria, negative bacteria, Citrus Canker xanthomonas, potato early blight, Aspergillus Niger, Decaprous and other fungal activities.
    Herbarin
  • HY-167641
    Malvone A
    		Inhibitor
    Malvone A is an antifungal compound found in Malva sylvestris, with an ED50 of 24 μg/mL against V. dahliae. Malvone A may be used for research in the field of anti-infective agents.
    Malvone A
  • HY-B0856R
    Validamycin A (Standard)
    		Inhibitor
    Validamycin A (Standard) is the analytical standard of Validamycin A. This product is intended for research and analytical applications. Validamycin A, a fungicidal, is an agricultural antibiotic. Validamycin A is originally isolated from Streptomyces hygroscopicus var. limoneus. Validamycin A inhibits the growth of A. flavus, with a MIC of 1 μg/mL. Validamycin A shows potent inhibitory activity against trehalase of Rhizoctonia solani, with an IC50 of 72 μM. Validamycin A is a reversible tyrosinase inhibitor, with a Ki of 5.893 mM.
    Validamycin A (Standard)
  • HY-B1324R
    Oxiconazole nitrate (Standard)
    		Inhibitor
    Oxiconazole nitrate (Standard) is the analytical standard of Oxiconazole nitrate. This product is intended for research and analytical applications. Oxiconazole (Ro 13-8996) nitrate is a broad spectrum anti-fungal agent which can inhibit the growth of Candida, Aspergillus and Trichophyton. Oxiconazole nitrate is also a highly efficacious activator of CYP3A4 transactivation, which could be antagonized by Rifampicin (HY-B0272) in a competitive manner. Oxiconazole nitrate exhibits inhibitory effect against colorectal cancer (CRC) via peroxiredoxin-2 (PRDX2)-mediated autophagy arrest.
    Oxiconazole nitrate (Standard)
  • HY-N15583
    Purpuride
    		Inhibitor
    Purpuride is a sesquiterpene ester found in aciduric fungi. Purpuride shows moderate antibacterial activities against Candida albicans, Enterobacter aerogenes and Pseudomonas aeruginosa with MIC values ranging from 1.2 to 3.3 μM.
    Purpuride
  • HY-121935R
    Tecnazene (Standard)
    		Inhibitor
    Tecnazene (Standard) is the analytical standard of Tecnazene. This product is intended for research and analytical applications. Tecnazene (2,3,5,6-Tetrachloronitrobenzene) is a fungicide and is used as a sprout inhibitor on stored potatoes.
    Tecnazene (Standard)
Cat. No. Product Name / Synonyms Application Reactivity