2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W701943
    Fenhexamid-d10
    Fenhexamid-d10 is the deuterium labeled Fenhexamid (HY-118065). Fenhexamid, a botryticide, is a sterol biosynthesis inhibitor. Fenhexamid shows fungicide efficient against the plant pathogenic fungus Botryotinia fuckeliana (Botrytis cinerea).
    Fenhexamid-d<sub>10</sub>
  • HY-119540
    Furametpyr
    		Inhibitor
    Furametpyr is a fungicide used to control rice sheath blight. Furametpyr exhibits a wide variety of metabolites in rats, through recombinant human cytochrome P450.
    Furametpyr
  • HY-120753
    Rimocidin
    		Inhibitor
    Rimocidin, a polyene macrolide, is an antifungal compound. Rimocidin shows broad‐spectrum antifungal activity against multiple plant‐pathogenic fungi.
    Rimocidin
  • HY-126795
    Aspergillin PZ
    Aspergillin PZ is a novel isoindole-alkaloid from Aspergillus awamori. Aspergillin PZ induces conidia of P. oryzae to deform moderately.
    Aspergillin PZ
  • HY-W014612R
    Eugenol acetate (Standard)
    		Inhibitor
    Eugenol acetate (Standard) is the analytical standard of Eugenol acetate. This product is intended for research and analytical applications. Eugenol acetate (Eugenyl acetate) is an antibacterial, anticancer, anti-inflammatory and antioxidant. Eugenol acetate inhibits NF-κB and enhances the expression of p53 and p21 (WAF1). Eugenol acetate can prevent chemically induced skin cancer, inhibit cancer cell proliferation and induce apoptosis.
    Eugenol acetate (Standard)
  • HY-137356R
    Prochloraz manganese (Standard)
    		Inhibitor
    Prochloraz manganese (Standard) is the analytical standard of Prochloraz manganese. This product is intended for research and analytical applications. Prochloraz manganese is an antifungal agent, and is used in agricultural industries.
    Prochloraz manganese (Standard)
  • HY-W008927A
    (Z)-Fluoxastrobin
    (Z)-Fluoxastrobin is fungicide agent. (Z)-Fluoxastrobin has excellent control of important seed and soilborne pathogens.
    (Z)-Fluoxastrobin
  • HY-146106
    Antitubercular agent-22
    		Inhibitor
    Antitubercular agent-22 (Compound 2) is a potent anticandidiasis and antitubercular agent with MIC values of 2.34 µg/ml and 2 µg/ml against Candida albicans MTCC 3017 and M. tuberculosis (H37Rv), respectively.
    Antitubercular agent-22
  • HY-N1817
    Demethoxypiplartine
    		Inhibitor
    Demethoxypiplartine is an amide alkaloids which can be isolated from Piper flaviflorum and Piper sarmentosum. Demethoxypiplartine has antifungal activity against Cryptococcus neoformans with the IC50 of 18.1 μg/mL.
    Demethoxypiplartine
  • HY-P5016
    CRAMP-18 (mouse)
    		Inhibitor
    CRAMP-18 (mouse) is an antibiotic peptide without hemolytic activity. CRAMP-18 (mouse) has good inhibitory activity against Gram-negative bacteria, such as S. typhimurium and P. aeruginosa. CRAMP-18 (mouse) has the potential to study antifungal, antibacterial and antitumor.
    CRAMP-18 (mouse)
  • HY-N1500S1
    Pulegone-d8
    		Inhibitor
    Pulegone-d8 is deuterated labeled Pulegone (HY-N1500). Pulegone is a monoterpene ketone compound widely present in the essential oils of many plants. Pulegone can also be used as a bird repellent. Pulegone has multiple activities such as anti-inflammatory, antibacterial, antifungal, and anti-hyperalgesic effects. Pulegone is particularly effective against bacteria of the Salmonella species.
    Pulegone-d<sub>8</sub>
  • HY-B1702
    Nifuroxime
    		Inhibitor
    Nifuroxime is an anti-infective agent. Nifuroxime can be used in the research of fungal infections.
    Nifuroxime
  • HY-148423
    Picarbutrazox
    		Inhibitor
    Picarbutrazox is a potent pesticide and fungicide. Picarbutrazox can be used for corn and soybean to control Pythium and Phytophthora. Picarbutrazox can be used in agricultural production and control.
    Picarbutrazox
  • HY-144391
    Chitin synthase inhibitor 1
    		Inhibitor
    Chitin synthase inhibitor 1 is a potent and selective chitin synthase (CHS) inhibitor (IC50=0.12 mM). Chitin synthase inhibitor 1 has potent antifungal activity against drug-resistant fungi variants.
    Chitin synthase inhibitor 1
  • HY-W726127
    Propamocarb hydrochloride
    		Inhibitor
    Propamocarb hydrochloride is a systemic fungicide. Propamocarb hydrochloride is widely used to protect cucumbers, tomatoes and other plants from pathogens.
    Propamocarb hydrochloride
  • HY-151419
    Chitin synthase inhibitor 9
    		Inhibitor
    Chitin synthase inhibitor 9 is a chitin synthase (CHS) inhibitor with broad-spectrum antifungal activity. Chitin synthase inhibitor 9 can be used in the research of fungi infection.
    Chitin synthase inhibitor 9
  • HY-76200B
    Voriconazole camphorsulfonate
    		Inhibitor
    Voriconazole (UK-109496) camphorsulfonate is a second-generation, broad-spectrum triazole antifungal agent that inhibits fungal ergosterol biosynthesis. Voriconazole camphorsulfonate exerts its antifungal activity by inhibition of 14-α-lanosterol demethylation, which is mediated by fungal cytochrome P450 enzymes.
    Voriconazole camphorsulfonate
  • HY-N12023
    Deacetylnomilin
    		Inhibitor
    Deacetylnomilin can be isolated from Citrus reticulata and has antibacterial and antifungal activity. Deacetylnomilin is a potent inhibitor of cell proliferation with an IC50 value of 0.005 ug/mL against estrogen receptor-positive (ER+) cells.
    Deacetylnomilin
  • HY-106371
    Siccanin
    		Inhibitor
    Siccanin is a succinate dehydrogenase (SDH) inhibitor (IC50=0.9 μM) with species-selective activity. Siccanin also is a antibiotic against pathogenic fungi.
    Siccanin
  • HY-129806
    Rugulosin
    		Inhibitor
    Rugulosin is a crystalline colouring matter of Penicillium rugulosum Thom. Rugulosin shows markedly specific antibacterial activity and moderately antifungal activity.
    Rugulosin
Cat. No. Product Name / Synonyms Application Reactivity