2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N7719R
    Oosporein (Standard)
    		Inhibitor
    Oosporein (Standard) is the analytical standard of Oosporein (HY-N7719). This product is intended for research and analytical applications. Oosporein is a microbial metabolite and a red crystalline toxin produced by various fungi. Oosporein can promote the reproduction of fungi in host bodies by inhibiting insect immunity, and possesses multiple activities such as antibacterial, antiviral (HSV), and insecticidal effects. Oosporein can inhibit plant growth. In addition, Oosporein can also induce apoptosis, cell membrane damage, oxidative stress, and mitochondrial damage. Oosporein has certain antitumor activity.
    Oosporein (Standard)
  • HY-N12180A
    Hodgkinsine
    		Inhibitor
    Hodgkinsine is an opioid receptor agonist and NMDA receptor antagonist, which has analgesic and anti-injurial effects. In addition, Hodgkinsine has antiviral, antibacterial and antifungal activities.
    Hodgkinsine
  • HY-W280349
    1-Phenylsemicarbazide
    1-Phenylsemicarbazide is an antifungal agent. 1-Phenylsemicarbazide has the potential for preventing mold growth on industrial products.
    1-Phenylsemicarbazide
  • HY-153618
    Antifungal agent 53
    		Inhibitor
    Antifungal agent 53 (A03) is a potent inhibitor of Candida albicans CYP51 with antifungal activity. Antifungal agent 53 prevents the formation of fungi biofilms. Antifungal agent 53 also exhibits good safety.
    Antifungal agent 53
  • HY-B0454S2
    Miconazole-d2
    Miconazole-d2 is the deuterium labeled Miconazole. Miconazole (R18134) is an imidazole antifungal agent. Miconazole also has antibacterial effects.
    Miconazole-d<sub>2</sub>
  • HY-P11141
    Jelleine-II
    		Inhibitor
    Jelleine-II is a short chain antibacterial peptide derived from royal jelly, with broad-spectrum antibacterial activity. Jelleine-II has antibacterial activity against yeast, fungi, Gram positive bacteria, and Gram negative bacteria. Jelleine-II can be used in the study of infectious conditions.
    Jelleine-II
  • HY-N12276
    (±)-Emodin bianthrone
    		Inhibitor
    (±)-Emodin bianthrone (compound 10), a natural product, exhibits antimalarial, antitubercular and ntifungal activities.
    (±)-Emodin bianthrone
  • HY-137794
    Tetramethylkaempferol
    		Inhibitor 99.93%
    Tetramethylkaempferol is an antifungal agent. Tetramethylkaempferol shows antifungal activity against Candida albicansCandida albicans with an IC50 value of 17.63 µg/mL.
    Tetramethylkaempferol
  • HY-172362
    SDH-IN-22
    		Inhibitor
    SDH-IN-22 (Compound SEZC7) is the inhibitor for succinate dehydrogenase (SDH) with an IC50 of 16.6 μM. SDH-IN-22 exhibits antifungal activity that inhibits Magnaporthe grisea with an EC50 of 0.5 mg/L.
    SDH-IN-22
  • HY-W706466
    3',5,5'-Trichlorosalicylanilide
    3',5,5'-Trichlorosalicylanilide (TCSA) acts as an inhibitor of fungal morphogenesis, preventing biofilm formation and hindering host cell invasion.
    3',5,5'-Trichlorosalicylanilide
  • HY-N15653
    Heveadride
    		Inhibitor
    Heveadride is a fungal metabolite and an antifungal agent. Heveadride is active against various filamentous fungi and some human pathogenic yeasts. Heaveadride induces down-regulation of TNFα-induced NF-κB activity in human chronic myeloid leukemia cells with an IC50 of 82.7 μM.
    Heveadride
  • HY-152249
    Antibacterial agent 131
    		Inhibitor 98.52%
    Antibacterial agent 131 is a quinoline derivative. Antibacterial agent 131 has antimicrobial effect. Antibacterial agent 131 destroys the integrity of the fungal cells via blocking ergosterol production.
    Antibacterial agent 131
  • HY-Y1313S
    3-Nitrobenzoic acid-d4
    		Inhibitor
    3-Nitrobenzoic acid-d4 (m-Carboxynitrobenzene-d4; m-Nitrobenzenecarboxylic acid-d4; m-Nitrobenzoic acid-d4) is the deuterium labeled 3-Nitrobenzoic acid (HY-Y1313). 3-Nitrobenzoic acid is an antioxidant and antibacterial agent that can kill bacteria and fungi. 3-Nitrobenzoic acid can be degraded or reduced by certain bacteria (such as Pseudomonas) and fungi (such as white rot fungi) into aldehydes and alcohols.
    3-Nitrobenzoic acid-d<sub>4</sub>
  • HY-123691
    7-O-Demethyl rapamycin
    		Inhibitor
    7-O-Demethyl rapamycin, a derivative of Rapamycin (HY-10219), has antifungal activity and immunosuppressant properties. 7-O-Demethyl rapamycin has useful tumor cell growth-inhibiting activity.
    7-O-Demethyl rapamycin
  • HY-155658
    Antifungal agent 62
    		Inhibitor
    Antifungal agent 62 (Compound 3a) is a fungicidal agent with excellent fungicidal activities against Fusarium oxysporum f.sp. cucumerinum. Antifungal agent 62 can be used for antiviral and fungicidal research.
    Antifungal agent 62
  • HY-155331
    Antifungal agent 77
    		Inhibitor
    Antifungal agent 77 (Compound 13h) is an antifungal agent. Antifungal agent 77 (500 μg/mL) also shows good insecticidal activity against Mythimna separate, Helicoverpa armigera, Ostrinia nubilalis, and Spodoptera frugiperda with a death rate of 30%, 25%, 40%, and 25%. Antifungal agent 77 shows toxicity in zebrafish embryo with a LC50 of 2.43 μg/mL.
    Antifungal agent 77
  • HY-151442
    Antifungal agent 43
    		Inhibitor
    Antifungal agent 43 (compound B05) is an antifungal agent. Antifungal agents 43 has antifungal activity by inhibiting biofilm formation. Antifungal agent 43 has low toxicity in human cancer cell lines.
    Antifungal agent 43
  • HY-N10282
    Isodihydroauroglaucin
    		Inhibitor
    Isodihydroauroglaucin, a fungal metabolite, shows antibacterial activity.
    Isodihydroauroglaucin
  • HY-143406
    Antifungal agent 25
    		Inhibitor
    Antifungal agent 25 is a potent broad-spectrum antifungal agent. Antifungal agent 25 shows antifungal effect against Candida albicans and fluconazole-resistant strain of Candida albicans. Antifungal agent 25 stable metabolic property in vivo.
    Antifungal agent 25
  • HY-112176R
    Kanosamine hydrochloride (Standard)
    		Inhibitor
    6-Hydroxytropinone (Standard) is the analytical standard of 6-Hydroxytropinone. This product is intended for research and analytical applications. 6-Hydroxytropinone is a Alkaloids product that can be isolated from the roots of Atropa belladonna.
    Kanosamine hydrochloride (Standard)
Cat. No. Product Name / Synonyms Application Reactivity