2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N3556
    Caulilexin C
    		Inhibitor 99.82%
    Caulilexin C is a phytoalexin from crucifers with antifungal activity.
    Caulilexin C
  • HY-153409
    Antifungal agent 48
    		Inhibitor
    Antifungal agent 48 (Example 308) is an antifungal agent. Antifungal agent 48 is active against Cryptococcus neoformans with a MIC value of 11 μM.
    Antifungal agent 48
  • HY-W007980
    Antifungal agent 98
    		Inhibitor 99.83%
    Antifungal agent 98 (compound 2) is an antifungal agent. Antifungal agent 98 (100 μg/mL) shows insecticidal activity against Bipolaris sorokinianum, Fusarium oxysporium f. sp.vasinfectum, Pyricularia oryzae, Alternaria Brassicae and Alternaria alternata with a death rate of 41.5%, 40.0%, 23.4, 36.8%, and 35.0%.
    Antifungal agent 98
  • HY-17583R
    Griseofulvin (Standard)
    		Inhibitor
    Griseofulvin (Standard) is the analytical standard of Griseofulvin. This product is intended for research and analytical applications.
    Griseofulvin (Standard)
  • HY-17514S2
    Itraconazole-d9
    Itraconazole-d9 is the deuterium labeled Itraconazole. Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC50 of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor.
    Itraconazole-d<sub>9</sub>
  • HY-W109523
    2-Butylbenzo[d]isothiazol-3(2H)-one
    		Inhibitor
    2-Butylbenzo[d]isothiazol-3(2H)-one is a bioactive compound with potent antibacterial and antifungal activity. 2-Butylbenzo[d]isothiazol-3(2H)-one is often used as a pesticide ingredient in agriculture to protect crops from diseases. 2-Butylbenzo[d]isothiazol-3(2H)-one is also used in coatings to prevent the growth of mold and algae. 2-Butylbenzo[d]isothiazol-3(2H)-one is also used as a preservative in personal care products to extend the shelf life of the product.
    2-Butylbenzo[d]isothiazol-3(2H)-one
  • HY-119759
    Lipoxamycin
    		Inhibitor
    Lipoxamycin is an antifungal antibiotic and a potent serine palmitoyltransferase inhibitor with an IC50 of 21 nM.
    Lipoxamycin
  • HY-129315
    Deacylketoconazole
    		Inhibitor 99.60%
    Deacylketoconazole (N-Deacetylketoconazole; R-39519) is an orally active metabolite of Ketoconazole (HY-B0105). Deacylketoconazole exhibits antifungal and antibacterial activity. Deacylketoconazole is cytotoxic in rats hepatocyte.
    Deacylketoconazole
  • HY-137989
    Voriconazole N-oxide
    		Inhibitor
    Voriconazole N-oxide (Voriconazole oxynitride) is a potent antifungal agent. Voriconazole N-oxide has phototoxicity and photocarcinogenicity. Voriconazole N-oxide does not sensitize keratinocytes to ultraviolet B (UVB).
    Voriconazole N-oxide
  • HY-N3187
    Nimbin
    		Inhibitor 99.59%
    Nimbin is an orally active intermediate limonoid found in Azadirachta. Nimbin prevents tau aggregation and increases cell viability. Nimbin is effective inhibits the envelope protein of dengue virus. Nimbin has anti-inflammatory, antipyretic, antifungal, antihistamine, antiseptic, antioxidant, anti-cancer and anti-viral properties. Nimbin can across blood-brain barrier. Nimbin is promising for research of neurodegenerative diseases and viral infections.
    Nimbin
  • HY-N12496
    Di-O-methylhonokiol
    		Inhibitor 99.59%
    Di-O-methylhonokiol is a natural phenolic compound that can be isolated from magnolia flowers. Di-O-methylhonokiol has significant antibacterial activity against Gram-positive bacteria, acid-fast bacilli, and yeast-like and filamentous fungi. Di-O-methylhonokiol can be used in the study of fungal infections.
    Di-O-methylhonokiol
  • HY-N0626AR
    Potassium sorbate (Standard)
    		Inhibitor
    Potassium sorbate (Standard) is the analytical standard of Potassium sorbate. This product is intended for research and analytical applications. Potassium sorbate (Sorbic acid potassium) is a highly efficient and nonpoisonous food preservative. Potassium sorbate generally is an effective inhibitor of most molds and yeasts and some bacteria. Potassium sorbate can be used to prepare antimicrobial biodegradable films with sweet potato starch.
    Potassium sorbate (Standard)
  • HY-100751
    N-563
    		≥98.0%
    N-563 is a deoxyspergualin mimetic that stimulates immune responses and enhances resistance to Candida albicans in mice.
    N-563
  • HY-118149A
    (±)9-HpODE
    		Inhibitor 98.9%
    (±)9-HpODE is a long chain lipid hydroperoxide, is a product of linoleic acid peroxidation. (±)9-HpODE can induce oxidation of intracellular glutathione (GSH). (±)9-HpODE also exhibits antimicrobial activity against various fungal and bacterial pathogens.
    (±)9-HpODE
  • HY-B0849R
    Azoxystrobin (Standard)
    		Inhibitor
    Azoxystrobin (Standard) is the analytical standard of Azoxystrobin. This product is intended for research and analytical applications. Azoxystrobin is a broad-spectrum β-methoxyacrylate fungicide. Azoxystrobin inhibits mitochondrial respiration by binding to the Qo site of the cytochrome bc1 complex and inhibiting electron transfer. Azoxystrobin induces the production of reactive oxygen species (ROS) and induces cell apoptosis.
    Azoxystrobin (Standard)
  • HY-N10229
    Harzianum A
    		Inhibitor
    Harzianum A is a trichothecene compound. Harzianum A has no antibacterial activity against Gram-negative and Gram-positive bacteria, but has antifungal activity. In addition, Harzianum A is cytotoxic to tumor cells.
    Harzianum A
  • HY-N0673
    Pseudolaric Acid A
    		Inhibitor 99.90%
    Pseudolaric Acid A is a diterpene acid isolated from Pseudolarix kaempferi, has antifungal, cytotoxic and antifertile activities.
    Pseudolaric Acid A
  • HY-B0139S
    Flucytosine-13C,15N2
    		Inhibitor 98.06%
    Flucytosine-13C,15N2 (NSC 103805-13C,15N2; Ro 2-9915-13C,15N2) is a 13C- and 15N-labeled Flucytosine (HY-B0139).
    Flucytosine-<sup>13</sup>C,15</sup>N<sub>2</sub>
  • HY-B0852R
    Tebuconazole (Standard)
    		Inhibitor
    Tebuconazole (Standard) is the analytical standard of Tebuconazole. This product is intended for research and analytical applications. Tebuconazole is an orally active agricultural azole fungicide which can also inhibit CYP51 with IC50s of 0.9 and 1.3 μM for Candida albicans CYP51 (CaCYP51) and truncated Homo sapiens CYP51 (Δ60HsCYP51), respectively. Tebuconazole induces lipid accumulation and oxidative stress in HepG2 Cells. Tebuconazole decreases MAC-T cells viability and proliferation, induces ER-stress-mediated apoptosis and increases oxidative stress levels in MAC-T cells.
    Tebuconazole (Standard)
  • HY-W012349
    2′-Hydroxychalcone
    		Inhibitor
    2′-Hydroxychalcone is a hydroxyl derivative of chalcones with anticancer activities. 2'-Hydroxychalcone inhibits NF-κB pathway and induces autophagy and apoptosis in breast cancer cells. 2′-Hydroxychalcone shows a better antifungal activity against the complex Paracoccidioides spp.
    2′-Hydroxychalcone
Cat. No. Product Name / Synonyms Application Reactivity