2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-U00007A
    Stilbamidine dihydrochloride
    		Inhibitor
    Stilbamidine dihydrochloride is a diamidine compound derived from Stilbene and used chiefly in the form of its crystalline isethionate salt in treating various fungal infections.
    Stilbamidine dihydrochloride
  • HY-163459
    HWY-289
    		Inhibitor ≥98.0%
    HWY-289 is a semisynthetic protoberberine derivative, has broad-spectrum and potent activities against phytopathogenic fungi, particularly Botrytis cinerea (EC50 = 1.34 μg/mL). HWY-289 changes the morphology of the mycelium and the internal structure of cells. HWY-289 reduces ATP content, ATPase activities, and key enzyme activities in the TCA cycle.
    HWY-289
  • HY-128033
    Fenpropimorph
    		Inhibitor 98.70%
    Fenpropimorph is a fungicide that inhibits the sterol pathway. Fenpropimorph inhibits δ8-δ7-sterol isomerase in yeast at low concentrations, with δ14-sterol reductase being blocked at higher levels, preventing the biosynthesis of ergosterol. Fenpropimorph also inhibits sterol synthesis in certain plants and mammalian cells.
    Fenpropimorph
  • HY-135761
    Penconazole
    		Inhibitor 98.91%
    Penconazole is a typical triazole fungicide, and mainly applied on apples, grapes, and vegetables to control powdery mildew. Penconazole inhibits sterol biosynthesis in fungi. Penconazole decrease AChE activity in the cerebrum and cerebellum of rats.
    Penconazole
  • HY-N7023
    7-Prenyloxycoumarin
    		99.87%
    7-Prenyloxycoumarin (7-O-Prenylumbelliferone) is a secondary metabolite from the endophytic fungus of Annulohypoxylon ilanense.
    7-Prenyloxycoumarin
  • HY-N0150R
    Monensin sodium (Standard)
    		Inhibitor
    Monensin (sodium) (Standard) is the analytical standard of Monensin (sodium). This product is intended for research and analytical applications. Monensin (Monensin A) sodium, an orally active antibiotic, is an ionophore that mediates Na+/H+ exchange. Monensin sodium is a potent Wnt signaling inhibitor. Monensin sodium causes a marked enlargement of the multivesicular bodies (MVBs) and regulates exosome secretion. Monensin sodium can be used for bacterial, fungal, and parasitic infections research, and shows anticancer effects.
    Monensin sodium (Standard)
  • HY-129337
    Reveromycin A
    		Inhibitor 99.00%
    Reveromycin A, a benzoquinoid antibiotic isolated from the genus Streptomyces, is a selective inhibitor of protein synthesis in eukaryotic cells. Reveromycin A inhibits bone resorption by inducing apoptosis specifically in osteoclasts. Reveromycin A has antiproliferative activity against tumor cell lines and antifungal activity.
    Reveromycin A
  • HY-12772S
    Hydroxy Itraconazole-d8
    		99.71%
    Hydroxy Itraconazole-d8 is the deuterium labeled Hydroxy Itraconazole. Hydroxy Itraconazole is an active metabolite of Itraconazole (ITZ), which is a triazole antifungal agent.
    Hydroxy Itraconazole-d<sub>8</sub>
  • HY-150686
    Chitin synthase inhibitor 4
    		Inhibitor 99.48%
    Chitin synthase inhibitor 4 (compound 4fh) is a chitin synthase inhibitor with fungicidal effect. Chitin synthase inhibitor 4 is a potential chitin synthase-based fungicide in agriculture.
    Chitin synthase inhibitor 4
  • HY-10863S
    Anandamide-d8
    		Inhibitor 99.90%
    Anandamide-d8 is a deuterated labeled Anandamide. Anandamide is an endocannabinoid. Anandamide modulates both neuronal and immune functions through two protein-coupled cannabinoid receptors (CB1 and CB2). Anandamide can activate numerous other receptors like PPARS, TRPV1, and GPR18/GPR55. Anandamide also has potential anti-fungal and anti-inflammatory activities. Anandamide can be used for the research of Alzheimer’s disease (AD) and ulcerative colitis.
    Anandamide-d<sub>8</sub>
  • HY-W010649
    Isoxazole
    		Inhibitor 99.98%
    Isoxazole is a member of the five-membered heterocycle drug scaffold. Isoxazole has been used as a BET bromodomain inhibitor and can improve β-cell function in a diabetic mouse model. Isoxazole and its derivatives exhibit broad biological activities (such as antimicrobial, antibacterial, antifungal, antiviral, anticancer, anti-inflammatory, immunomodulatory, analgesic, anti-tuberculosis, and anti-diabetic effects). For example, the bicyclic Isoxazole can act as an HSP90 inhibitor, and the tricyclic Isoxazole is promising as a selective multidrug resistance protein (MRP1) inhibitor​.
    Isoxazole
  • HY-129060
    Flutrimazole
    		99.34%
    Flutrimazole is an imidazole antifungal with dual anti-inflammatory and antifungal activity. Flutrimazole shows scarce transdermal penetration. Flutrimazole has the advantageous in the research of topical fungal infections with an inflammatory component.
    Flutrimazole
  • HY-N3035
    Tetrahydroepiberberine
    		Inhibitor 99.20%
    Tetrahydroepiberberine is a isoquinoline alkaloid isolated from Corydalis impatiens (Pall). Tetrahydroepiberberine has antifungal and selective inhibition against the PI-3 virus activities.
    Tetrahydroepiberberine
  • HY-N2923
    β-Amyrin acetate
    		Inhibitor 99.47%
    β-Amyrin acetate is a triterpenoid with potent anti-inflammatory, antifungal, anti-diabetic, anti-hyperlipidemic activities. β-Amyrin acetate can inhibit HMG-CoA reductase activity by locating in the hydrophobic binding cleft of HMG CoA reductase.
    β-Amyrin acetate
  • HY-B0490R
    Hygromycin B (Standard)
    		Inhibitor
    Hygromycin B (Standard) is the analytical standard of Hygromycin B. This product is intended for research and analytical applications. Hygromycin B is an aminoglycoside antibiotic active against prokaryotic and eukaryotic cells.
    Hygromycin B (Standard)
  • HY-N12513
    Cyclo(L-Phe-trans-4-OH-L-Pro)
    		Inhibitor 99.76%
    Cyclo(L-Phe-trans-4-OH-L-Pro) is an antifungal peptides.
    Cyclo(L-Phe-trans-4-OH-L-Pro)
  • HY-W015399
    4-Methylcinnamic acid
    		Inhibitor 99.63%
    4-Methylcinnamic acid, a Cinnamic acid analog, can be used as a intervention catalyst for overcoming antifungal tolerance. 4-Methylcinnamic acid can improve the potency of cell wall-disrupting agents.
    4-Methylcinnamic acid
  • HY-B1211
    Dehydroacetic acid
    		Inhibitor 99.85%
    Dehydroacetic acid (Biocide 470F) is a pyrone derivative. Dehydroacetic acid has antibacterial, antifungal and phytotoxic activities. Dehydroacetic acid can be added to cosmetics, food and beverages for preservation and other purposes. Dehydroacetic acid can also be used to synthesize various heterocycles and cycloaddition products.
    Dehydroacetic acid
  • HY-N2145
    4',7-Dimethoxyisoflavone
    		Inhibitor 98.20%
    4',7-Dimethoxyisoflavone is isolated from the leaves of Albizzia lebbeck, which shows antifungal activity.
    4',7-Dimethoxyisoflavone
  • HY-W585866
    Alternariol, methyl ether
    		99.96%
    Alternariol, methyl ether is a common mycotoxin found in spoiled grains and is mutagenic and carcinogenic in vitro.
    Alternariol, methyl ether
Cat. No. Product Name / Synonyms Application Reactivity