2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N12257
    Antimycin A2
    		Inhibitor ≥99.0%
    Antimycin A2 is the component of the antibiotic antimycin A. Antimycin A is an antibiotic, that exhibits inhibitory activity against fungi and some insects through inhibition of respiration and cytochrome b reoxidation.
    Antimycin A2
  • HY-B1858
    Isoprothiolane
    		Inhibitor 99.91%
    Isoprothiolane is a blast fungicide with antifungal, anti-inflammatory and insecticidal activities. Isoprothiolane primarily acts on fungi during the penetration and growth stages of infecting hyphae. Isoprothiolane can be used as an insecticide, pesticide, etc. In addition, Isoprothiolane can reduce serum phospholipid and total lipid concentrations, regulating lipid metabolism. Isoprothiolane is also used in the research of fatty liver.
    Isoprothiolane
  • HY-16779B
    Fosravuconazole L-lysine ethanolate
    		Inhibitor 99.86%
    Fosravuconazole L-lysine ethanolate (BMS-379224 L-lysine ethanolate), a proagent of Ravuconazole, is an orally active broad spectrum antifungal agent. Fosravuconazole L-lysine ethanolate can be used for candidiasis, onychomycosis and parasitemia research.
    Fosravuconazole L-lysine ethanolate
  • HY-66053
    5-Bromo-3-pyridinol
    		Inhibitor 99.45%
    5-Bromo-3-pyridinol is a potential fungicide. 5-Bromo-3-pyridinol provides at least 70% control of Plasmopara viticola at 200 ppm. Chlorinated derivatives of 5-Bromo-3-pyridinol have been used to control fungal infections of plants.
    5-Bromo-3-pyridinol
  • HY-123037
    Triadimefon
    		Inhibitor 98.12%
    Triadimefon is a triazole fungicide used to control powdery mildew, rusts, and other fungal pests on grains, fruit and vegetable crops, turf, shrubs, and trees. Triadimefon inhibits lanosterol 14α-demethylase, interfering with oxidative demethylation reactions in the ergosterol biosynthesis pathway of fungi, and also blocks gibberellin biosynthesis.
    Triadimefon
  • HY-B0846
    Dimethomorph
    		Inhibitor 99.13%
    Dimethomorph is a fungicide belongs to the fungicide group of sterol biosynthesis inhibitor. Dimethomorph can inhibit fungal cell wall formation. Dimethomorph also inhibits androgen receptor (AR) activity in MDA-kb2 cells with an IC20 of 0.263 µM.
    Dimethomorph
  • HY-W010549
    2-Methylcyclohexanone
    		98.89%
    2-Methylcyclohexanone is a substrate of EryKR1. 2-Methylcyclohexanone can be biotransformed by Fusarium sp. EryKR1 has certain biocatalyst activity.
    2-Methylcyclohexanone
  • HY-125776
    Kresoxim-methyl
    		Inhibitor 99.83%
    Kresoxim-methyl (BAS 490 F), a Strobilurin-based fungicide, inhibits the respiration at the complex III (cytochrome bc1 complex). Kresoxim-methyl binds to complex III from yeast with an apparent Kd of 0.07 μM proving a high affinity for this enzyme.
    Kresoxim-methyl
  • HY-N0654
    Corypalmine
    		Inhibitor 99.48%
    Corypalmine is an alkaloid from Stephania cepharantha. Corypalmine is an antifungal.
    Corypalmine
  • HY-17373S1
    Posaconazole-d4
    		Inhibitor 99.90%
    Posaconazole-d4 is a deuterium-labeled form of Posaconazole. Posaconazole is a broad-spectrum, second generation, triazole compound with antifungal activity.
    Posaconazole-d<sub>4</sub>
  • HY-116474
    Viridicatol
    		Inhibitor 99.93%
    Viridicatol, a quinolinone alkaloid, is isolated from the fermentation of an endophytic fungus Penicillium sp. R22 in Nerium indicum. Viridicatol has strong antifungal activity against Staphylococcus aureus with MIC value of 15.6 μg/mL.
    Viridicatol
  • HY-U00058
    Diflucortolone valerate
    		Inhibitor 99.90%
    Diflucortolone valerate is a powerful corticosteroid used topically for the research of various skin diseases.
    Diflucortolone valerate
  • HY-N2512
    1-Monomyristin
    		Inhibitor ≥98.0%
    1-Monomyristin, extracted from Serenoa repens, inhibits the hydrolysis of 2-oleoylglycerol (IC50=32 μM) and fatty acid amide hydrolase (FAAH) activity (IC50=18 μM). 1-Monomyristin shows antibacterial activity against Staphylococcus aureus and Aggregatibacter actinomycetemcomitans and also antifungal activity against Candida albicans.
    1-Monomyristin
  • HY-B2144I
    Chitosan (≥90% deacetylated,viscosity 10 mPa.s)
    		Inhibitor
    Chitosan (Deacetylated chitin) (≥90% deacetylated,viscosity 10 mPa.s) is a polysaccharide obtained by deacetylating chitin, and exhibits antimicrobial activity against various bacteria and fungi. Chitosan (≥90% deacetylated,viscosity 10 mPa.s) can be used as a versatile biomaterial in drug delivery, tissue engineering, and wound healing.
    Chitosan (≥90% deacetylated,viscosity 10 mPa.s)
  • HY-B1978
    Iprodione
    		Inhibitor 99.25%
    Iprodione is an orally active diformimide fungicide. Iprodione can specifically cause oxidative damage by producing free radicals (ROS). Iprodione is also an antiandrogen agent that delays adolescent development in rats and reduces sexual behavior and reproductive ability in rats.
    Iprodione
  • HY-106542A
    Eberconazole nitrate
    		99.76%
    Eberconazole nitrate is a dichlorinated imidazole derivative with antifungal activity. Eberconazole nitrate is more effective than Clotrimazole (HY-10882), Ketoconazole (HY-B0105), and Miconazole (HY-B0454). Eberconazole nitrate has potential for the study of dermatophytosis.
    Eberconazole nitrate
  • HY-100711A
    Prodigiosin hydrochloride
    		Inhibitor 98.00%
    Prodigiosin (Prodigiosine) hydrochloride is a red pigment produced by bacteria as a bioactive secondary metabolite. Prodigiosin hydrochloride is a potent proapoptotic agent, and inhibits Wnt/β-catenin pathway. Prodigiosin hydrochloride has antibacterial, antifungal, antiprotozoal, antimalarial, immunosuppressive, and anticancer properties.
    Prodigiosin hydrochloride
  • HY-N7133
    Diphenylamine hydrochloride
    		99.92%
    Diphenylamine hydrochloride (N-Phenylaniline hydrochloride) is an antihyperglycemic agent with oral activity and a common structure in non-steroidal anti-inflammatory drugs (NSAIDs) that uncouples oxidative phosphorylation in mitochondria, leading to a decrease in hepatic cell ATP levels and causing liver cell damage. Diphenylamine hydrochloride is also an industrial antioxidant, a dyeing mordant, and is used in agriculture as an antifungal and antibacterial agent.
    Diphenylamine hydrochloride
  • HY-12538
    Graveoline
    		Inhibitor 99.96%
    Graveoline (Rutamine) is an anti-cancer agent that can trigger apoptosis and autophagy in skin melanoma cells. Graveoline also exhibits antifungal activity.
    Graveoline
  • HY-108970
    Bafilomycin D
    		Inhibitor 99.30%
    Bafilomycin D is a specific inhibitor of vacuolar-type ATPase (V-ATPase). Bafilomycin D has antimicrobial, insecticidal, herbicidal and cytotoxic activity.
    Bafilomycin D
Cat. No. Product Name / Synonyms Application Reactivity