2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-113362
    Petroselinic acid
    		Inhibitor ≥98.0%
    Petroselinic acid, a positional isomer of oleic acid, is isolated from the vegetable oil of Coriandrum sativum fruits. Petroselinic acid is used as substrate for sophorolipid fermentation. Petroselinic acid inhibits the biofilm formation in microorganisms, exhibits antibacterial and antifungal activities. Petroselinic acid is orally active[4.
    Petroselinic acid
  • HY-N1500
    Pulegone
    		Inhibitor
    Pulegone is a monoterpene ketone compound widely present in the essential oils of many plants. Pulegone can also be used as a bird repellent. Pulegone has multiple activities such as anti-inflammatory, antibacterial, antifungal, and anti-hyperalgesic effects. Pulegone is particularly effective against bacteria of the Salmonella species.
    Pulegone
  • HY-108450
    Polygodial
    		Inhibitor 98.74%
    Polygodial (Poligodial) is an antifungal potentiator. Polygodial is a sesquiterpene with anti-hyperalgesic properties.
    Polygodial
  • HY-111741
    M700F048
    		Inhibitor 99.81%
    M700F048 is a major plant metabolite of fungicide Fluxapyroxad.
    M700F048
  • HY-12396
    Aminothiazole
    		Inhibitor 99.98%
    Aminothiazole (2-Aminothiazole), a typical heterocyclic amine, is a precursor for the synthesis of biologically active molecules including sulfur agents, biocides, fungicides, antibiotics, dyes and chemical reaction accelerators.
    Aminothiazole
  • HY-B0935
    Benzyl benzoate
    		Inhibitor 99.94%
    Benzyl benzoate (Phenylmethyl benzoate) is an orally active anti-scabies agent, acaricide (EC50= 0.06 g/m2) and fungicide. Benzyl benzoate is an angiotensin II (Ang II) inhibitor with antihypertensive effects. Benzyl benzoate can be used in perfumes, pharmaceuticals and the food industry.
    Benzyl benzoate
  • HY-N6869
    Dehydroabietic acid
    		Inhibitor 99.75%
    Dehydroabietic acid is a diterpene resin acid that can be isolated from Pinus and Picea. Dehydroabietic acid has anti-bacterial, anti-fungal, anti-inflammatory, and anticancer activities. Dehydroabietic acid is a dual PPAR-α/γ agonist and PPAR-γ partial agonist, which can attenuate insulin resistance (IR) and hepatic steatosis induced by HFD-consumption in mice.
    Dehydroabietic acid
  • HY-N6051
    (-​)​-Maackiain
    		Inhibitor 99.91%
    (-)-Maackiain is a pterocarpan phytoalexin produced from Sophora flavescens. (-)-Maackiain is toxic to several genera of fungal pathogens of legume and non legume hosts. (-)-Maackiain enhances the activation of NLRP3 inflammasome, inhibits the activation of NF-κB pathway, exhibiting thereby immunostimulatory and anti-inflammatory activities. (-)-Maackiain is orally active.
    (-​)​-Maackiain
  • HY-B0238
    Amorolfine hydrochloride
    		Inhibitor 99.84%
    Amorolfine (Ro 14-4767/002) hydrochloride is a potent anti-fungal agent. Amorolfine hydrochloride inhibits ergosterol biosynthesis. Amorolfine hydrochloride has the potential for the research of Neoscytalidium dimidiatum onychomycosis.
    Amorolfine hydrochloride
  • HY-W004282
    Undecanoic acid
    		Inhibitor 99.90%
    Undecanoic acid (Undecanoate) is a monocarboxylic acid with antifungal property. Undecanoic acid inhibits the production of exocellular keratinase, lipase and the biosynthesis of several phospholipids in T. rubrum.
    Undecanoic acid
  • HY-N3617
    Coniferin
    		Inhibitor 99.13%
    Coniferin (Laricin) is a glucoside of coniferyl alcohol. Coniferin inhibits fungal melanization. Coniferin inhibits the release of certain hormones from cells, including Prostaglandin E2 and Thromboxane B2.
    Coniferin
  • HY-Y0989
    Acetophenone
    		99.84%
    Acetophenone (1-Phenylethan-1-One) is an organic compound with simple structure. Acetophenone can be bioreduced to phenylethanol (PEA).
    Acetophenone
  • HY-P1939
    Cyclo(L-Leu-L-Pro)
    		Inhibitor 99.84%
    Cyclo(L-Leu-L-Pro) is an inhibitory substance targeting to production of norsolorinic acid (NA，a precursor of aflatoxin)，which can be isolated from A. xylosoxidans NFRI-A1. Cyclo(L-Leu-L-Pro) inhibits accumulation of NA by A. parasiticus NFRI-95 and inhibits spore formation. Cyclo(L-Leu-L-Pro) inhibits aflatoxin production with an IC50 of 0.2 mg/mL in A. parasiticus SYS-4.
    Cyclo(L-Leu-L-Pro)
  • HY-139983
    SDH-IN-1
    		Inhibitor 99.95%
    SDH-IN-1 (compound 4i) is a succinate dehydrogenase (SDH) inhibitor with an IC50 of 4.53 μM. SDH-IN-1 has potent antifungal activities. SDH-IN-1 displays potent activity against S. sclerotiorum (EC50 of 0.14 mg/L).
    SDH-IN-1
  • HY-D1200
    Malachite Green Carbinol base
    		Antagonist
    Malachite Green Carbinol base (MGOH, MGCB) is a derivative of Malachite green (MG) with not fluorescence. Malachite green carbinol base (MGOH, MGCB), as a pH regulation reagent, MGCB molecule could release OH- under UV light irradiation and generate a progressive shift in pH values. MGCB solution turns from colorless to deep green rapidly when exposed to a high-pressure UV lamp (500 W, 50 W/cm).
    Malachite Green Carbinol base
  • HY-B0370
    Tolnaftate
    		Inhibitor 99.28%
    Tolnaftate (NP-27) is a synthetic thiocarbamate used as an anti-fungal agent. .
    Tolnaftate
  • HY-B0736A
    Sertaconazole nitrate
    		Inhibitor 99.19%
    Sertaconazole nitrate (FI7056) is a broad-spectrum topical antifungal agent, exhibits anti-inflammatory activity via activation of a p38-COX-2-PGE2 pathway. Sertaconazole nitrate is also a microtubule inhibitor, shows antiproliferative effect, induces apoptosis and autophagy, and can also inhibit the migration of cells.
    Sertaconazole nitrate
  • HY-119976
    Boscalid
    		Inhibitor 99.29%
    Boscalid is an anti-fungal agent. Boscalid is a succinate dehydrogenase (SDH) inhibitor.
    Boscalid
  • HY-N6746
    Citrinin
    		Inhibitor 99.94%
    Citrinin (NSC 186) is a mycotoxin that causes food contamination and has different toxic effects. Citrinin is an effective oral anticancer agent. Citrinin has various regulatory effects on mouse immune system, including regulating the number of immune cells, inducing apoptosis and autophagy of immune cells, altering toll-like receptor expression and cytokine production. Citrinin can induce oxidative stress and lead to early apoptosis of oocytes. Low doses of Citrinin have neuroprotective effects against glutamate-induced excitotoxicity in rat cortical neurons. In addition, Citrinin also has antibacterial activity.
    Citrinin
  • HY-120435
    Tyrothricin
    		Inhibitor
    Tyrothricin is a polypeptide antibiotic mixture isolated from Bacillus brevis and consists of tyrocidines and gramicidins. Tyrothricin shows activity against bacteria, fungi and some viruses. Tyrothricin containing formulations are used in sore throat agents and in agents for the healing of infected superficial and small-area wounds.
    Tyrothricin
Cat. No. Product Name / Synonyms Application Reactivity