Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Fungal Related Products (2278)
Antibodies (1)
Related Compound Screening Libraries (1)

By Effects:	Controls (3) Inhibitors (2039) Antagonists (3) Modulators (2) Chemical (1)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-W014589

2,4-Di-tert-butylphenol	Inhibitor	99.97%
2,4-Di-tert-butylphenol (2,4-DTBP) is an orally active RXRα activator and a human estrogen receptor ligand with anti-inflammatory and antioxidant activities, which can induce apoptosis in tumor cells. 2,4-Di-tert-butylphenol can activate the RXRα subtype in LXRα/RXRα, PPARγ/RXRα, and hormone receptor β/RXRα. 2,4-Di-tert-butylphenol also has antiviral and antifungal activities and has the potential to inhibit Aβ-induced neurotoxicity. 2,4-Di-tert-butylphenol can be used as an intermediate in the preparation of antioxidants and UV stabilizers, and is also used in the manufacture of drugs and fragrances.

HY-W016288

Naphthalene-2,3-Dicarboxaldehyde	Inhibitor	99.37%
Naphthalene-2,3-Dicarboxaldehyde (2,3-Naphthalenedicarboxaldehyde), a phthaldehyde derivative, is a fungal ASADH inhibitor (K_i: 45 μM). Naphthalene-2,3-Dicarboxaldehyde inhibits the growth of C. albicans CAF2-1 with IC₅₀ of 58.2 μM and MIC of 12 μg/mL.

HY-17006A

Caspofungin	Inhibitor	99.74%
Caspofungin is a potent antifungal agent. Caspofungin inhibits the synthesis of the fungal cell wall component β-(l,3)-D-glucan.

HY-B0935

Benzyl benzoate	Inhibitor	99.94%
Benzyl benzoate (Phenylmethyl benzoate) is an orally active anti-scabies agent, acaricide (EC₅₀= 0.06 g/m²) and fungicide. Benzyl benzoate is an angiotensin II (Ang II) inhibitor with antihypertensive effects. Benzyl benzoate can be used in perfumes, pharmaceuticals and the food industry.

HY-N6051

(-)-Maackiain	Inhibitor	99.91%
(-)-Maackiain is a pterocarpan phytoalexin produced from Sophora flavescens. (-)-Maackiain is toxic to several genera of fungal pathogens of legume and non legume hosts. (-)-Maackiain enhances the activation of NLRP3 inflammasome, inhibits the activation of NF-κB pathway, exhibiting thereby immunostimulatory and anti-inflammatory activities. (-)-Maackiain is orally active.

HY-B0238

Amorolfine hydrochloride	Inhibitor	99.84%
Amorolfine (Ro 14-4767/002) hydrochloride is a potent anti-fungal agent. Amorolfine hydrochloride inhibits ergosterol biosynthesis. Amorolfine hydrochloride has the potential for the research of Neoscytalidium dimidiatum onychomycosis.

HY-N0849

Dictamine	Inhibitor	99.60%
Dictamnine (Dictamine) exhibits cytotoxicity to human cervical and colon cancer cells and also has antibacterial and antifungal activities.

HY-N6939

Pseudolaric Acid B	Inhibitor	99.47%
Pseudolaric Acid B is an orally active diterpene acid. Pseudolaric Acid B has anti-fungal, anti-fertility, anti-angiogenesis and anticancer activity, and can induce tumor cell apoptosis and autophagy. In addition, Pseudolaric Acid B can inhibit the secretion of hepatitis B virus (HBV) and has immunosuppressive effect, selectively inhibiting the proliferation of T lymphocytes and the production of IL-2.

HY-119976

Boscalid	Inhibitor	99.80%
Boscalid is an anti-fungal agent. Boscalid is a succinate dehydrogenase (SDH) inhibitor.

HY-B0453

Econazole nitrate	Inhibitor	98.0%
Econazole nitrate is an imidazole class antifungal medication. Econazole nitrate also has antibacterial activity.

HY-116144

Picaridin	Inhibitor	99.25%
Picaridin (Lcaridin) is a broad spectrum arthropod repellent. Picaridin interacts with mosquito and tick olfactory receptor proteins. Picaridin repels Aedes aegypti. Picaridin exhibits considerable antibacterial, anticandidal and antifungal properties.

HY-N8432

Dipyrithione	Inhibitor	99.93%
Dipyrithione is a potent antimicrobial agent. Dipyrithione shows antifungal activity and antiproliferative activity. Dipyrithione induces apoptosis and cycle arrest at G1 phase. Dipyrithione shows anti-inflammatory activity in vivo. Dipyrithione shows anti-tumor activity. Dipyrithione has the potential for the research of dermatophytosis.

HY-N6746

Citrinin	Inhibitor	99.94%
Citrinin (NSC 186) is a mycotoxin that causes food contamination and has different toxic effects. Citrinin is an effective oral anticancer agent. Citrinin has various regulatory effects on mouse immune system, including regulating the number of immune cells, inducing apoptosis and autophagy of immune cells, altering toll-like receptor expression and cytokine production. Citrinin can induce oxidative stress and lead to early apoptosis of oocytes. Low doses of Citrinin have neuroprotective effects against glutamate-induced excitotoxicity in rat cortical neurons. In addition, Citrinin also has antibacterial activity.

HY-B0934

Ethylparaben	Inhibitor	99.53%
Ethylparaben is the ethyl ester of paraben and is used as an antifungal preservative and food additive.

HY-12396

Aminothiazole	Inhibitor	99.82%
Aminothiazole (2-Aminothiazole), a typical heterocyclic amine, is a precursor for the synthesis of biologically active molecules including sulfur agents, biocides, fungicides, antibiotics, dyes and chemical reaction accelerators.

HY-76200S

Voriconazole-d₃	Inhibitor	99.90%
Voriconazole-d₃ is the deuterium labeled Voriconazole. Voriconazole (UK-109496) is a second-generation, broad-spectrum triazole antifungal agent that inhibits fungal ergosterol biosynthesis. Voriconazole exerts its antifungal activity by inhibition of 14-α-lanosterol demethylation, which is mediated by fungal cytochrome P450 enzymes.

HY-B1729

Phenoxyethanol	Inhibitor	99.49%
Phenoxyethanol has a broad spectrum of antimicrobial agent. Phenoxyethanol is an uncouple agent in oxidative phosphorylation from respiration and competitively inhibits malate dehydrogenase. Phenoxyethanol is used as a preservative in cosmetic, vaccine, and textile, et al.

HY-W015590

2-Hydroxyphenylacetic acid		98.79%
2-Hydroxyphenylacetic acid is a metabolite of Phenylalanine and Tyrosine, and is also a product of the biotransformation of Phenylacetonitrile by marine fungi. 2-Hydroxyphenylacetic acid can be used as a potential biomarker for food. 2-Hydroxyphenylacetic acid can be used in the study of phenylketonuria and related hyperphenylalaninemias.

HY-121721

Inz-5	Inhibitor	98.82%
Inz-5 is a fungal-selective mitochondrial cytochrome bc1 inhibitor. Inz-5 impairs fungal virulence and prevents the evolution of agent resistance.

HY-N2584A

Isoxanthohumol	Inhibitor	99.91%
Isoxanthohumol is an orally active flavonoid compound. Isoxanthohumol has biological activities such as anti-tumor, anti-inflammatory, antioxidant, antiviral, antifungal, and inhibition of adipogenesis. Isoxanthohumol can induce apoptosis, autophagy, and migration of tumor cells. Isoxanthohumol is active against viruses such as HSV, BVDV, CMV, and Rhino. Isoxanthohumol can be used for the research of tumors, metabolic, and inflammatory diseases.

Antifungal Compound Library

Compound library containing all kinds of molecules with anti-fungal activity.

463compounds HY-L048

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Fungal

Fungal

Fungal Related Products (2278)

Antibodies (1)

Related Compound Screening Libraries (1)

Fungal Related Products (2278):