2. Anti-infection
  3. Fungal
  4. Naphthalene-2,3-Dicarboxaldehyde

Naphthalene-2,3-Dicarboxaldehyde  (Synonyms: 2,3-Naphthalenedicarboxaldehyde; Naphthalene-2,3-dialdehyde)

Cat. No.: HY-W016288 Purity: 99.25%
COA
SDS
Handling Instructions Technical Support

Naphthalene-2,3-Dicarboxaldehyde (2,3-Naphthalenedicarboxaldehyde), a phthaldehyde derivative, is a fungal ASADH inhibitor (Ki: 45 μM). Naphthalene-2,3-Dicarboxaldehyde inhibits the growth of C. albicans CAF2-1 with IC50 of 58.2 μM and MIC of 12 μg/mL.

For research use only. We do not sell to patients.

Naphthalene-2,3-Dicarboxaldehyde

Naphthalene-2,3-Dicarboxaldehyde Chemical Structure

CAS No. : 7149-49-7

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Based on 1 publication(s) in Google Scholar

Other Forms of Naphthalene-2,3-Dicarboxaldehyde:

Naphthalene-2,3-Dicarboxaldehyde Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Naphthalene-2,3-Dicarboxaldehyde

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Naphthalene-2,3-Dicarboxaldehyde (2,3-Naphthalenedicarboxaldehyde), a phthaldehyde derivative, is a fungal ASADH inhibitor (Ki: 45 μM). Naphthalene-2,3-Dicarboxaldehyde inhibits the growth of C. albicans CAF2-1 with IC50 of 58.2 μM and MIC of 12 μg/mL[1].

Molecular Weight

184.19

Formula

C12H8O2
CAS No.
Appearance

Solid

Color

Off-white to pink

SMILES

O=CC1=CC2=CC=CC=C2C=C1C=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

RT, stored under nitrogen

In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (542.91 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.4291 mL 27.1453 mL 54.2906 mL
5 mM 1.0858 mL 5.4291 mL 10.8581 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 5 mg/mL (27.15 mM); Clear solution

    This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: 99.37%

SDS (393 KB)

COA (251 KB) HNMR (115 KB) RP-HPLC (194 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 5.4291 mL 27.1453 mL 54.2906 mL 135.7265 mL
5 mM 1.0858 mL 5.4291 mL 10.8581 mL 27.1453 mL
10 mM 0.5429 mL 2.7145 mL 5.4291 mL 13.5726 mL
15 mM 0.3619 mL 1.8097 mL 3.6194 mL 9.0484 mL
20 mM 0.2715 mL 1.3573 mL 2.7145 mL 6.7863 mL
25 mM 0.2172 mL 1.0858 mL 2.1716 mL 5.4291 mL
30 mM 0.1810 mL 0.9048 mL 1.8097 mL 4.5242 mL
40 mM 0.1357 mL 0.6786 mL 1.3573 mL 3.3932 mL
50 mM 0.1086 mL 0.5429 mL 1.0858 mL 2.7145 mL
60 mM 0.0905 mL 0.4524 mL 0.9048 mL 2.2621 mL
80 mM 0.0679 mL 0.3393 mL 0.6786 mL 1.6966 mL
100 mM 0.0543 mL 0.2715 mL 0.5429 mL 1.3573 mL
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Naphthalene-2,3-Dicarboxaldehyde Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Naphthalene-2,3-Dicarboxaldehyde7149-49-72,3-Naphthalenedicarboxaldehyde Naphthalene-2,3-dialdehydeFungalInfectionanti-fungalC. albicansCAF2-1Inhibitorinhibitorinhibit

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