2. Signaling Pathways
  3. Immunology/Inflammation
  4. FAP

FAP

Fibroblast activation protein

Fibroblast activation protein (FAP) is a cell-surface serine protease that acts on various hormones and extracellular matrix components. FAP is highly upregulated in a wide variety of cancers, and is often used as a marker for pro-tumorigenic stroma.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-137331
    FAPI-46
    		98.57%
    FAPI-46 is a quinoline-based fibroblast activation protein (FAP)-targeted tracer. Use radioactivity FAPI-46 labeled with 68Ga or 177Lu can be used for tumor imaging in a variety of cancers and has higher tumor uptake rates and longer tumor accumulation.
    FAPI-46
  • HY-101801
    Ac-Gly-BoroPro
    		≥98.0%
    Ac-Gly-BoroPro is a selective FAP inhibitor with a Ki of 23 nM.
    Ac-Gly-BoroPro
  • HY-147057
    Rofapitide tetraxetan
    		99.54%
    Rofapitide tetraxetan (FAP-2286) is a potent and selective FAP-binding peptide with a mean IC50 value of 2.7 nM for binding to FAP. Rofapitide tetraxetan can be labeled with radionuclides for diagnostic applications. Rofapitide tetraxetan has antitumor activity.
    Rofapitide tetraxetan
  • HY-128643
    FAPI-4
    		99.47%
    FAPI-4 is a potent fibroblast activation protein (FAP) inhibitor for the targeting FAP. FAPI-4 can be used in cancer research. 68Ga-FAPI-4 PET/CT is a promising new diagnostic method for imaging various kinds of cancer, with good tumor-to-background contrast ratios.
    FAPI-4
  • HY-P99269
    Sibrotuzumab
    Sibrotuzumab (BIBH 1) is a humanized IgG1 monoclonal antibody targets fibroblast activation protein (FAP). Sibrotuzumab can be used for the research of colorectal cancer and non-small cell lung cancer (NSCLC).
    Sibrotuzumab
  • HY-P10944
    Unlabeled FXX489
    		Ligand 98.52%
    Unlabeled FXX489 (NNS309) is a fibroblast activation protein (FAP)-targeting ligand. Unlabeled FXX489 can be labeled with 68Ga and 177Lu and shows anticancer effects. Unlabeled FXX489 can be used for the study of pancreatic ductal adenocarcinoma (PDAC), non-small cell lung cancer (NSCLC), breast cancer (BC), and colorectal cancer (CRC).
    Unlabeled FXX489
  • HY-172317
    AZD2389
    		Inhibitor 98.99%
    AZD2389 is a potent and orally active FAP inhibitor. AZD2389 can be used for the study of metabolic dysfunction-associated steatohepatitis.
    AZD2389
  • HY-173374
    DOTAGA-FAP-2286-ALB
    		Inhibitor
    DOTAGA-FAP-2286-ALB is a derivative of Rofapitide tetraxetan (HY-147057). DOTAGA-FAP-2286-ALB is a selective fibroblast activation protein (FAP) inhibitor with an IC50 value of 67.5 nM. DOTAGA-FAP-2286-ALB enhances tumor retention via albumin interaction, prolonging blood circulation and improving radiometal complex stability (e.g., with 111In and 225Ac). DOTAGA-FAP-2286-ALB is promising for research of radionuclide therapy (TRT) of FAP-positive solid tumors.
    DOTAGA-FAP-2286-ALB
  • HY-145983
    Suc-Gly-Pro-AMC
    		99.16%
    Suc-Gly-Pro-AMC is a fluorescent substrate. Suc-Gly-Pro-AMC is a fibroblast activation protein (FAP) specific substrate. Suc-Gly-Pro-AMC reacts with recombinant porcine prolyl oligopeptidase. Suc-Gly-Pro-AMC can be used to study the activity of FAP, prolyl endopeptidase (PREP). Suc-Gly-Pro-AMC is used in glioma research.
    Suc-Gly-Pro-AMC
  • HY-100684
    UAMC-1110
    		Inhibitor 99.51%
    UAMC-1110 is a highly potent and selective inhibitor of fibroblast activation protein (FAP) with an IC50 of 3.2 nM. UAMC-1110 also inhibits prolyl oligopeptidase (PREP) with an IC50 of 1.8 μM.
    UAMC-1110
  • HY-153552A
    NH2-UAMC1110 TFA
    		Inhibitor 99.89%
    NH2-UAMC1110 TFA is a UAMC1110 (HY-100684) derivative that can be used in the synthesis of FAPI-QS. UAMC1110 is a fibroblast activation protein (FAP) inhibitor. FAPI-QS is a chelating agent that can be used to synthesize high tumor selectivity and high dose radiotracers for the diagnosis and treatment of tumors.
    NH2-UAMC1110 TFA
  • HY-147173
    FAPI-74
    		99.84%
    FAPI-74 is a PET (positron emission tomography) tracer targeting the fibroblast activation protein (FAP). FAPI-74 can be used for FAP-positive tumor research.
    FAPI-74
  • HY-145938
    OncoFAP
    		99.77%
    OncoFAP is an ultra-high-affinity ligand of fibroblast activation protein (FAP) for targeting applications with pan-tumoral potential.
    OncoFAP
  • HY-P10131
    3BP-3940
    		99.96%
    3BP-3940 is a highly potent and selective peptide inhibitor of FAP that targets cancer-associated fibroblasts (CAFs) in the tumor microenvironment. 3BP-3940 can be labeled with radionuclides (such as Ga-68) for precise tumor imaging or Lu-177 for the development of targeted anticancer technologies. 3BP-3940 accumulates in tumor lesions and can be used to diagnose and inhibit various solid cancers and CAFs-related diseases.
    3BP-3940
  • HY-47979
    FAP-IN-2
    		Inhibitor 99.93%
    FAP-IN-2 is a derivative of 99mTc-labeled isonitrile-containing fibroblast activation protein (FAPI) inhibitor. FAP-IN-2 can be used for tumor imaging. FAP-IN-2 has good stability, high uptake and good retention in the tumor site of mouse model.
    FAP-IN-2
  • HY-164725
    FAPI-mFS
    		Inhibitor 99.78%
    FAPI-mFS is an irreversible fibroblast activation protein (FAP) inhibitor, that enhances the uptake and retention time in cancer cells through its covalent binding property for FAP. FAPI-mFS can be used for cancer imaging the therapy, when labeled with radioactive 68Ga or 177Lu. FAPI-mFS can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).
    FAPI-mFS
  • HY-160289
    ARI-3144
    		Substrate 99.72%
    ARI-3144 is an excellent and specific substrate for fibroblast activation protein (FAP). ARI-3144 is usually coupled with the fluorophore 7-Amino-4-methylcoumarin (HY-D0027) (AMC) for detection and quantification of FAP.
    ARI-3144
  • HY-47979A
    FAP-IN-2 TFA
    		Inhibitor 99.92%
    FAP-IN-2 TFA is a 99mTc-labeled isonitrile-containing FAP inhibitor derivative that can be used for tumor imaging.
    FAP-IN-2 TFA
  • HY-125366
    ARI-3099
    		99.42%
    ARI-3099 is potent and selective inhibitor of FAP with a Ki value of 9 nM.
    ARI-3099
  • HY-164316
    FT-FAPI-12_9
    		99.07%
    FT-FAPI-12_9 is a FAP-binding moiety, which can be used for synthesis of FAP-targeted radiotracer FAPI-46 (HY-137331). FT-FAPI-12_9 can be used in the research of cancers.
    FT-FAPI-12_9
Cat. No. Product Name / Synonyms Application Reactivity