Cathepsin

Cathepsin Related Products (154):

By Effects:	Control (1) Inhibitors (112) Agonist (1) Activators (3) Inducer (1)

Cat. No.	Product Name	Effect	Purity

HY-D0843

N-Ethylmaleimide	Inhibitor	99.89%
N-Ethylmaleimide (NEM) derives from maleic acid, it can alkylates free sulfhydryl. N-Ethylmaleimide is an irreversible cysteine protease inhibitor. N-ethylmaleimide specific inhibits phosphate transport in mitochondria. N-Ethylmaleimide inhibits prolyl endopeptidase with an IC₅₀ value of 6.3 μM. N-Ethylmaleimide can be used to modify cysteine residues in proteins and peptides.

HY-18234A

Leupeptin hemisulfate	Inhibitor	99.39%
Leupeptin hemisulfate is a broad-spectrum, membrane-permeable protease inhibitor. Leupeptin hemisulfate potently inhibits serine, cysteine and threonine proteases. Leupeptin hemisulfate inhibits M^pro (the main protease of SARS-CoV-2) and also has anti-inflammatory activity.

HY-B0496

PMSF	Inhibitor	99.32%
PMSF (Phenylmethylsulfonyl fluoride) is a nonspecific and irreversible serine proteases inhibitor. PMSF inhibits some thiol proteases, non-protease enzymes, and acetylcholinesterase. PMSF can be used to prepare protein extracts from tissue and cell lysates.

HY-148905

p-Aminophenylmercuric acetate	Activator	99.07%
p-Aminophenylmercuric acetate is an organomercurial activator of matrix metalloproteinases (MMP). P-Aminophenylmercuric acetate participates in the activation and inhibition of MMP-8 by attacking protein sulfhydryl or inducing cysteine switching reaction. p-Aminophenylmercuric acetate promotes the shedding of betacellulin precursor (pro-BTC). p-Aminophenylmercuric acetate influences the binding of agonists and antagonists to the opiate receptor.

HY-P1645

Papain
Papain is a cysteine protease of the peptidase C1 family, which is used in food, pharmaceutical, textile, and cosmetic industries.

HY-106058

NCO-700	Inhibitor
NCO-700 is a dual cathepsin B and calcium-activated neutral protease (CANP) inhibitor with IC₅₀ values of 0.8 and 46 μM, respectively. NCO-700 reduces the degradation of myocardial fibrin by inhibiting protease activity. NCO-700 also has inhibitory effects on hormone-independent tumor cells, such as prostate cancer cells, and induces apoptosis. NCO-700 can be used to study myocardial ischemia and refractory hormone-independent tumors.

HY-14360

MK 1256	Inhibitor
MK 1256 is a highly selective and orally active inhibitor of tissue protease K (Cat K) with an IC₅₀ of 0.62 nM. MK 1256 shows extremely high selectivity towards other tissue proteases (all > 1100 times), with only a slightly lower selectivity for tissue protease F (Cat F) (110 times). MK 1256 exhibits strong anti-bone resorption activity in the osteoporosis model of rhesus monkeys with ovariectomy. MK 1256 can be used for research on osteoporosis.

HY-P1645A

Papain (1.5-10 units/mg)
Papain (1.5-10 units/mg) is a plant proteolytic enzyme in the cysteine protease family, widely used in food, medicine and other fields.

HY-100229

Aloxistatin	Inhibitor	99.94%
Aloxistatin (E64d) is a cell-permeable and irreversible broad-spectrum cysteine protease inhibitor. Aloxistatin (E64d) exhibits entry-blocking effect for MERS-CoV.

HY-16594

Lactacystin	Inhibitor	98.20%
Lactacystin is a potent, orally active, irreversible, cell-permeable, selective 20S proteasome inhibitor (IC₅₀ = 4.8 μM). Lactacystin also inhibits the lysosomal enzyme cathepsin A. Lactacystin inhibits cell growth and induces apoptosisand cell cycle arrest, and has antiviral and antioxidative activity. Lactacystin induces neurite outgrowth and hypertension. Lactacystin has the potential for the research of cancer, Neurological Disease, hypertension and Malaria, and so on^[2]^[6].

HY-W011063

Gly-Phe-β-naphthylamide		99.92%
Gly-Phe-β-naphthylamide is the substrate of Cathepsin C. Gly-Phe-β-naphthylamide can be used to study intralysosomal hydrolysis, lysosomal membrane permeability, and the function of cathepsin C.

HY-134434

Z-Arg-Arg-AMC hydrochloride		99.83%
Z-Arg-Arg-AMC hydrochloride is a selective substrate of cathepsin B.

HY-103351

Cathepsin G Inhibitor I	Inhibitor	≥99.0%
Cathepsin G Inhibitor I (compound 7) is an effective, selective, reversible, competitive, non-peptide cathepsin G inhibitor (IC₅₀=53 nM; K_i=63 nM).

HY-100231

Cathepsin inhibitor 1	Inhibitor	99.28%
Cathepsin inhibitor 1 (Compound 25) is a potent and selective inhibitor of Cathepsin, with pIC₅₀s of 7.9, 6.7, 6.0, 5.5 and 5.2 for CatL, CatL2, CatS, CatK, and CatB, respectively. Cathepsin inhibitor 1 is promising for research of osteoarthritis.

HY-D0843S

N-Ethylmaleimide-d₅	Inhibitor	99.90%
N-Ethylmaleimide-d₅ is the deuterium labeled N-Ethylmaleimide. N-Ethylmaleimide (NEM), a reagent that alkylates free sulfhydryl groups, is a cysteine protease inhibitor. N-ethylmaleimide specific inhibits phosphate transport in mitochondria. N-Ethylmaleimide is also a deubiquitinating enzyme inhibitor.

HY-P4217

Z-Gly-Pro-Arg-AMC hydrochloride	Inhibitor	98.63%
Z-Gly-Pro-Arg-AMC hydrochloride a fluorescent trypsin and cathepsin K substrate. Z-Gly-Pro-Arg-AMC hydrochloride can be used to determine trypsin and cathepsin K activity.

HY-118355

ALLM	Inhibitor	98.60%
ALLM (Calpain inhibitor II) is a potent inhibitor of calpain and cathepsin proteases. ALLM inhibits neuronal cell death and improves chronic neurological function after spinal cord injury (SCI).

HY-146985

Cathepsin X-IN-1	Inhibitor	99.62%
Cathepsin X-IN-1 (compound 25) is a potent Cathepsin X inhibitor with an IC₅₀ of 7.13 µM. Cathepsin X-IN-1 decreases PC-3 cell migration with low cytotoxic.

HY-P1315

Papain inhibitor	Inhibitor	99.60%
Papain inhibitor (Glycylglycyl-L-tyrosyl-L-arginine) acts as an effective competitive inhibitor to papain, with a K_i of 9 μM at pH 6.2.

HY-112818

S130	Inhibitor	99.43%
S130 is a high affinity, selective inhibitor of ATG4B (a major cysteine protease) with an IC₅₀ of 3.24 µM. S130 suppresses autophagy flux.

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