2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Cathepsin

Cathepsin

Cathepsin

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Cathepsins are protease enzymes, categorized into multiple families. Cathepsins can be serine protease, cysteine protease, or aspartyl protease. There are about 15 classes of cathepsins in humans (Cathepsin A, B, C, D, E, F, G, H, K, L, O, S, V, W, and Z). Cathepsins are active in the low pH milieu of lysosomes and are versatile in their functions. Like other enzymes, they are vital for the normal physiological functions such as digestion, blood coagulation, bone resorption, ion channel activity, innate immunity, complement activation, apoptosis, vesicular trafficking, autophagy, angiogenesis, proliferation, and metastasis, among scores of others.

Numerous pathologies have been attributed to the dysregulated cathepsins, some of which include arthritis, periodontitis, pancreatitis, macular degeneration, muscular dystrophy, atherosclerosis, obesity, stroke, Alzheimer's disease, schizophrenia, tuberculosis, and Ebola.

Cathepsin Isoform Specific Products:

Cathepsin Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-RS03328
    CTSD Human Pre-designed siRNA Set A
    		Inhibitor

    CTSD Human Pre-designed siRNA Set A contains three designed siRNAs for CTSD gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    CTSD Human Pre-designed siRNA Set A
  • HY-138208
    Z-Phe-Tyr(tBu)-diazomethylketone
    		Inhibitor ≥99.0%
    Z-Phe-Tyr(tBu)-diazomethylketone is a potent cathepsin L inhibitor. Z-Phe-Tyr(tBu)-diazomethylketone mediates reovirus disassembly. Z-Phe-Tyr(tBu)-diazomethylketone decreases viral detection.
    Z-Phe-Tyr(tBu)-diazomethylketone
  • HY-RS03329
    Ctsd Mouse Pre-designed siRNA Set A
    		Inhibitor

    Ctsd Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ctsd gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Ctsd Mouse Pre-designed siRNA Set A
  • HY-RS03340
    CTSL Human Pre-designed siRNA Set A
    		Inhibitor

    CTSL Human Pre-designed siRNA Set A contains three designed siRNAs for CTSL gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    CTSL Human Pre-designed siRNA Set A
  • HY-171045
    Abz-FRF(4NO2)
    Abz-FRF(4NO2) is an Abz-tripeptide substrate commonly used for studying the activity of enzymes, especially cysteine proteases such as Cathepsin X.
    Abz-FRF(4NO2)
  • HY-128523
    Kgp-IN-1
    		Inhibitor
    Kgp-IN-1 is an arginine-specific gingipain (Rgp) inhibitor extracted from patent WO2017201322A1, compound 13-R.
    Kgp-IN-1
  • HY-RS03322
    CTSB Human Pre-designed siRNA Set A
    		Inhibitor

    CTSB Human Pre-designed siRNA Set A contains three designed siRNAs for CTSB gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    CTSB Human Pre-designed siRNA Set A
  • HY-144813
    Gü2602
    		Inhibitor 98.13%
    Gü2602 is a potent, reversible cathepsin K (CatK) inhibitor with a Ki of 0.013 nM for mature CatK (mCatK). Gü2602 suppresses the autocatalytic activation of the cathepsin K zymogen.
    Gü2602
  • HY-128523A
    Kgp-IN-1 hydrochloride
    		Inhibitor
    Kgp-IN-1 hydrochloride is an arginine-specific gingipain (Rgp) inhibitor extracted from patent WO2017201322A1, compound 13-R.
    Kgp-IN-1 hydrochloride
  • HY-112318
    GSK-2793660 free base
    		Inhibitor
    GSK-2793660 (free base) is an oral, irreversible inhibitor of Cathepsin C (CTSC). GSK-2793660 (free base) can be used for the research of bronchiectasis.
    GSK-2793660 free base
  • HY-P1759
    N-CBZ-Phe-Arg-AMC
    		99.88%
    N-CBZ-Phe-Arg-AMC (Z-FR-AMC) is a cathepsin substrate used in assessment activity of lysosomal cathepsin enzymes.
    N-CBZ-Phe-Arg-AMC
  • HY-103353A
    SID 26681509 quarterhydrate
    		Inhibitor 98.02%
    SID 26681509 quarterhydrate is a potent, reversible, competitive, and selective inhibitor of human cathepsin L with an IC50 of 56 nM. SID 26681509 quarterhydrate inhibits in vitro propagation of malaria parasite Plasmodium falciparum and inhibits Leishmania major with IC50s of 15.4 μM and 12.5 μM, respectively. SID 26681509 quarterhydrate shows no inhibitory activity against cathepsin G.
    SID 26681509 quarterhydrate
  • HY-153613
    Ac-PLVE-FMK
    		Inhibitor 98.0%
    Ac-PLVE-FMK (Ac-Pro-Leu-Val-Glu(OMe)-CH2F), a tetrapeptidyl m-FMKs, is a Cats inhibitor. Ac-PLVE-FMK can be used for the research of cancer.
    Ac-PLVE-FMK
  • HY-P4340
    Arg-Arg-AMC
    Arg-Arg-AMC is a highly selective substrate of Cathepsin B. Arg-Arg-AMC can be used to cathepsin B activity assay in cancer cells, while cathepsin B is assocaited with cell invasive and metastatic phenotype in numerous types of cancer.
    Arg-Arg-AMC
  • HY-W796158
    Z-DEVD-CMK
    		Inhibitor
    Z-DEVD-CMK is an irreversible inhibitor of most of the cathepsins in vitro.
    Z-DEVD-CMK
  • HY-122161
    JNJ-10311795
    		Inhibitor 98.66%
    JNJ-10311795 (RWJ-355871), a potent dual inhibitor of neutrophil cathepsin G (Ki = 38 nM) and mast cell chymase (Ki = 2.3 nM), exhibits noteworthy antiinflammatory activity.
    JNJ-10311795
  • HY-152204
    Cathepsin L/S-IN-1
    		Inhibitor
    Cathepsin L/S-IN-1 is a dual inhibitor of Cathepsin L and Cathepsin S with IC50s of 4.10 μM and 1.79 μM, respectively. Cathepsin L/S-IN-1 shows a significant antimetastatic and invasive effects on pancreatic cancer BxPC-3 and PANC-1 cells.
    Cathepsin L/S-IN-1
  • HY-137392
    Cathepsin L-IN-4
    Cathepsin L-IN-4 is an inhibitor of cathepsin L with IC50 at nanomolar concentrations.
    Cathepsin L-IN-4
  • HY-162477
    TS-24
    		Inhibitor 98.96%
    TS-24 is an inhibitor for cathepsin S, with an IC50 of 4.3 μM. TS-24 exhibits radiosensitizing activity in wild type breast cancer susceptibility gene 1 (BRCA1) and in TNBC xenograft mice model, through induction of apoptosis.
    TS-24
  • HY-RS03325
    CTSC Human Pre-designed siRNA Set A
    		Inhibitor

    CTSC Human Pre-designed siRNA Set A contains three designed siRNAs for CTSC gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    CTSC Human Pre-designed siRNA Set A
Cat. No. Product Name / Synonyms Species Source
Cat. No. Product Name / Synonyms Application Reactivity
Cathepsin Isoform Comparison

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