2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. CDK

CDK

Cyclin dependent kinase

CDK

Related Products

PDF 1.19 MB

CDKs (Cyclin-dependent kinases) are serine-threonine kinases first discovered for their role in regulating the cell cycle. They are also involved in regulating transcription, mRNA processing, and the differentiation of nerve cells. CDKs are relatively small proteins, with molecular weights ranging from 34 to 40 kDa, and contain little more than the kinase domain. In fact, yeast cells can proliferate normally when their CDK gene has been replaced with the homologous human gene. By definition, a CDK binds a regulatory protein called a cyclin. Without cyclin, CDK has little kinase activity; only the cyclin-CDK complex is an active kinase.

There are around 20 Cyclin-dependent kinases (CDK1-20) known till date. CDK1, 4 and 5 are involved in cell cycle, and CDK 7, 8, 9 and 11 are associated with transcription.

CDK levels remain relatively constant throughout the cell cycle and most regulation is post-translational. Most knowledge of CDK structure and function is based on CDKs of S. pombe (Cdc2), S. cerevisia (CDC28), and vertebrates (CDC2 and CDK2). The four major mechanisms of CDK regulation are cyclin binding, CAK phosphorylation, regulatory inhibitory phosphorylation, and binding of CDK inhibitory subunits (CKIs).

CDK Isoform Specific Products:

CDK Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-145389
    SZ-015268
    		Inhibitor
    SZ-015268 is a CDK7 inhibitor with an IC50 of 23.56 nM. SZ-015268 has extremely significant anti-tumor advantages. SZ-015268 inhibits HCC70, OVCAR-3, HCT116 and HCC1806 cells proliferation with IC50s of 33, 80.56, 12.53, and 61.55 nM, respectively.
    SZ-015268
  • HY-149963
    PROTAC CDK9 degrader-6
    		Inhibitor
    PROTAC CDK9 degrader-6 is a PROTAC targeting to CDK9 sepcifically. PROTAC CDK9 degrader-6 mediates CDK9 degradation via the proteasome. PROTAC CDK9 degrader-6 degrades CDK9 with DC50s of 0.10 μM and 0.14 μM for the CDK942 and CDK955 isoforms, respectively.
    PROTAC CDK9 degrader-6
  • HY-RS02360
    Cdk13 Mouse Pre-designed siRNA Set A
    		Inhibitor

    Cdk13 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cdk13 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Cdk13 Mouse Pre-designed siRNA Set A
    Cdk13 Mouse Pre-designed siRNA Set A
  • HY-173510
    CLK2/3-IN-1
    		Inhibitor
    CLK2/3-IN-1 (Compound 7c) is an orally active CLK2/3 inhibitor (EC50: 5.07 nM and 30.03 nM, respectively). CLK2/3-IN-1 binds to Lys193 and Lys186 of CLK2/3 via hydrogen bonds. CLK2/3-IN-1 can inhibit the proliferation of SW480 tumor cells (IC50: 163 nM). CLK2/3-IN-1 can be used to study CLK-related tumor diseases.
    CLK2/3-IN-1
  • HY-156795
    PROTAC CDK9/CycT1 Degrader-2
    		Inhibitor
    PROTAC CDK9/CycT1 Degrader-2 is a inhibitor of CDK9, with the IC50 of 45 nM.
    PROTAC CDK9/CycT1 Degrader-2
  • HY-161978
    CDK4/6-IN-22
    		Inhibitor
    CDK4/6-IN-22 (Compound 1-A) is a CDK4 and CDK6 dual inhibitor.
    CDK4/6-IN-22
  • HY-161768
    VCC972839:01
    		Inhibitor
    VCC972839:01 is an inhibitor for cyclin dependent kinase (CDK9), with IC50 of 7 nM. VCC972839:01 inhibits the cell viability of SCLC cells in nanomolar levels. VCC972839:01 induces apoptosis through an intrinsic pathway. VCC972839:01 exhibits antitumor activity in mouse model.
    VCC972839:01
  • HY-113831
    CLK1/2-IN-3
    		Inhibitor
    LK1/2-IN-3 (compound 3) is a potent and selective CLK1 and CLK2 inhibitor with IC50 values of 1.1, 2.1, 130, 260, 260 nM for CLK1, CLK2, SRPK1, SRPK2, SRPK3, respectively. CLK1/2-IN-3 shows anti-proliferative activity. CLK1/2-IN-3 reduces the levels of endogenous phosphorylated SR proteins and increases the expression of S6K mRNAs.
    CLK1/2-IN-3
  • HY-162985
    JHD205
    		Inhibitor
    JHD205 is a CDK4/6 inhibitor that induces apoptosis and DNA damage. JHD205 inhibits DNA repair by upregulating Caspase3 and p-H2AX. JHD205 has superior potency to Abemaciclib (HY-16297A) in a xenograft chick embryo breast cancer model..
    JHD205
  • HY-118902
    Aloisine B
    		Inhibitor
    Aloisine B (compound 9) is a cyclin-dependent kinase (CDK) inhibitor. Aloisine B inhibits cell proliferation by arresting cells in both G1 and G2 via competing with ATP-binding pocket.
    Aloisine B
  • HY-146680
    FLT3/ITD-IN-4
    		Inhibitor
    FLT3/ITD-IN-4 (Compound 16) is a selective FMS-like tyrosine kinase 3 internal tandem duplications (FLT3-ITD) inhibitor with an IC50 of 2.3 nM. FLT3/ITD-IN-4 can be used for acute myeloid leukemia research.
    FLT3/ITD-IN-4
  • HY-P3893
    PSTAIR
    		Inhibitor
    PSTAIR is a monoclonal antibody that recognizes the PSTAIR sequence in Cdc28, PSTAIR can be used as loading control.
    PSTAIR
  • HY-163640
    CDK4 degrader 1
    		Degrader
    CDK4 degrader 1 (ML 1–71) is a molecular glue degrader that targets CDK4.
    CDK4 degrader 1
  • HY-N6954R
    Garcinone C (Standard)
    		Inhibitor
    Garcinone C (Standard) is the analytical standard of Garcinone C. This product is intended for research and analytical applications. Garcinone C, a xanthone derivative, is a natural compound extracted from Garcinia oblongifolia that is used as an anti-inflammatory, astringency and granulation-promoting medicine, and has potential cytotoxic effects on certain cancers. Garcinone C stimulates the expression levels of ATR and 4E-BP1, arrests the cell cycle, inhibits cell viability of the human Nasopharyngeal carcinoma (NPC) cell lines CNE1, CNE2, HK1 and HONE1 in a time‑ and dose‑dependent manner through inhibition of Hedgehog signaling pathway. Garcinone C is orally active.
    Garcinone C (Standard)
  • HY-RS02350
    Cdk1 Rat Pre-designed siRNA Set A
    		Inhibitor

    Cdk1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Cdk1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Cdk1 Rat Pre-designed siRNA Set A
    Cdk1 Rat Pre-designed siRNA Set A
  • HY-173348
    BLINK15
    		Inhibitor
    BLINK15 is a BBB-penetrant CDK5 inhibitor. BLINK15 lowers CDK5 activity for both complexes CDK5/p35 (IC50 = 29.34 nM) and CDK5/p25 (IC50 = 12.08 nM). BLINK15 offers anti-diabetic and neuroprotective benefits. BLINK15 lowers blood glucose, enhances cognition, and reduces neurodegeneration in T2D mice.
    BLINK15
  • HY-RS02376
    Cdk2 Rat Pre-designed siRNA Set A
    		Inhibitor

    Cdk2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Cdk2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Cdk2 Rat Pre-designed siRNA Set A
    Cdk2 Rat Pre-designed siRNA Set A
  • HY-160941
    CDK2-IN-29
    		Inhibitor
    CDK2-IN-29 (Compound 13q) is an inhibitor for cyclin-dependent kinase (CDK), with IC50 of 96 nM and 360 nM, for CDK 2 and CDK 4, respectively.
    CDK2-IN-29
  • HY-170992
    Autophagy agonist-1
    		Inhibitor
    Autophagy agonist-1 (compound 22) is an Autophagy agonist. Autophagy agonist-1 exhibits significant anticancer activity against HepG2 cells and normal cells with IC50s of 8.8 μM and > 50 μM. Autophagy agonist-1 induces G1/S phase cell cycle arrest and inhibits CDK4 and CyclinD1 expression while upregulating P21. Autophagy agonist-1 promotes the accumulation of autophagosomes and the proteins LC3 and PINK1, enhancing autophagy and mitophagy in HepG2 cells.
    Autophagy agonist-1
  • HY-176142
    YX0798
    		Inhibitor
    YX0798 is a selective and orally active CDK9 inhibitor (Kd: 0.28 nM). YX0798 downregulates the oncoprotein c-MYC and pro-survival protein MCL-1. YX0798 disrupts the cell cycle and results in transcriptomic reprogramming, eventually leading to cell apoptosis. YX0798 has antitumor activity.
    YX0798
Cat. No. Product Name / Synonyms Species Source
Cat. No. Product Name / Synonyms Application Reactivity
CDK Isoform Comparison

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.