2. Signaling Pathways
  3. GPCR/G Protein
    Immunology/Inflammation
  4. CCR

CCR

CC chemokine receptor

CCR

Related Products

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CCR (Chemokine receptors) are cytokine receptors found on the surface of certain cells that interact with a type of cytokine called achemokine. There have been 19 distinct chemokine receptors described in mammals. Each has a 7-transmembrane (7TM) structure and couples to G-protein for signal transduction within a cell, making them members of a large protein family of G protein-coupled receptors. Following interaction with their specific chemokine ligands, chemokine receptors trigger a flux in intracellular calcium (Ca2+) ions (calcium signaling). This causes cell responses, including the onset of a process known as chemotaxis that traffics the cell to a desired location within the organism. Chemokine receptors are divided into different families, CXC chemokine receptors, CC chemokine receptors, CX3C chemokine receptors and XC chemokine receptors that correspond to the 4 distinct subfamilies of chemokines they bind. Specific chemokine receptors provide the portals for HIV to get into cells, and others contribute to inflammatory diseases and cancer.

CCR Isoform Specific Products:

CCR Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-14230
    INCB9471
    		Antagonist
    INCB9471 is a potent, selective and orally active CCR5 antagonist. INCB9471 shows anti-HIV-1 activity.
    INCB9471
  • HY-111321
    Fuscin
    		Inhibitor
    Fuscin, a fungal metabolite, CCR5 receptor antagonist with anti-HIV effects. Fuscin is a respiration and oxidative phosphorylation inhibitor, and also a mitochondrial SH-dependent transport-linked functions inhibitor.
    Fuscin
  • HY-B0155
    Vicriviroc
    		Antagonist
    Vicriviroc (SCH 417690) is an orally active CCR5 antagonist with the IC50 of 10 nM, and also inhibts MIP-1α and intracellular calcium release induced by the ligand RANTES (10 nM) with the IC50 values of 0.91 nM and 16 nM,,respectively. Vicriviroc can inhibits human immunodeficiency virus type 1 (HIV-1) infection, and can also used for study of cancer.
    Vicriviroc
  • HY-RS02152
    Ccr2 Mouse Pre-designed siRNA Set A
    		Inhibitor

    Ccr2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ccr2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Ccr2 Mouse Pre-designed siRNA Set A
  • HY-173491
    CXCR2/CCR7 antagonist-1
    		Antagonist
    CXCR2/CCR7 antagonist-1 (compound 6) is a potent CXCR2 and CCR7 dual antagonist with IC50s of 0.0046 and 0.0014 μM, respectively. CXCR2/CCR7 antagonist-1 can be used in the study of cancer metastasis and autoimmune diseases.
    CXCR2/CCR7 antagonist-1
  • HY-P991168
    Velaprumig
    		Inhibitor
    Velaprumig is a monoclonal antibody targeting human CD99, CCL25, and anti-human Aβ (Aβ-47F). Velaprumig regulates immune cell migration and reduces β-amyloid-related pathological processes, exerting immunomodulatory and potential anti - Alzheimer's disease activities.
    Velaprumig
  • HY-RS02153
    Ccr2 Rat Pre-designed siRNA Set A
    		Inhibitor

    Ccr2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ccr2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Ccr2 Rat Pre-designed siRNA Set A
  • HY-12079
    CP-481715
    		Antagonist
    CP-481715 is a potent, reversible and selective CCR1 antagonist with a Kd of 9.2 nM for human CCR1. CP-481715 is >100-fold selective for CCR1 as compared with a panel of G-protein-coupled receptors including related chemokine receptors. CP-481715 has the potential for rheumatoid arthritis and other inflammatory diseases research.
    CP-481715
  • HY-RS02157
    CCR4 Human Pre-designed siRNA Set A
    		Inhibitor

    CCR4 Human Pre-designed siRNA Set A contains three designed siRNAs for CCR4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    CCR4 Human Pre-designed siRNA Set A
  • HY-136788A
    ALK4290 dihydrochloride
    		Inhibitor
    ALK4290 dihydrochloride (AKST4290 dihydrochlorid) is a potent and orally active CCR3 inhibitor extracted from patent US20130261153A1, compound Example 2, with a Ki of 3.2 nM for hCCR3. ALK4290 can be used for the research of neovascular age-related macular degeneration and Parkinsonism.
    ALK4290 dihydrochloride
  • HY-14388
    PF-232798
    		Antagonist
    PF-232798 is an orally active CCR5 antagonist with anti-HIV effects.
    PF-232798
  • HY-101038
    ZK 756326
    		Agonist
    ZK756326 is a nonpeptide chemokine receptor agonist for the CC chemokine receptor CCR8.
    ZK 756326
  • HY-13245B
    (Rac)-PF-4136309
    		Antagonist ≥98.0%
    (Rac)-PF-4136309 is an isoform of PF-4136309 (HY-13245), which is a potent, selective, and orally bioavailable CCR2 antagonist, with IC50s of 5.2 nM, 17 nM and 13 nM for human, mouse and rat CCR2.
    (Rac)-PF-4136309
  • HY-171685
    Anti-CCL2 (Carlumab)-MC-Vc-PAB-DMEA-PEG2-Duocarmycin SA
    		Antagonist
    Anti-CCL2 (Carlumab)-MC-Vc-PAB-DMEA-PEG2-Duocarmycin SA is an antibody-drug conjugate (ADC) consisting of the humanized anti-CCL2 (chemokine ligand 2) antibody Carlumab (HY-P99188) conjugated with the linker MC-Vc-PAB-DMEA-PEG2 and the DNA alkylator Duocarmycin SA (HY-12456). Anti-CCL2 (Carlumab)-MC-Vc-PAB-DMEA-PEG2-Duocarmycin SA can be used in cancer research.
    Anti-CCL2 (Carlumab)-MC-Vc-PAB-DMEA-PEG2-Duocarmycin SA
  • HY-50084
    CCR2-RA
    		Antagonist
    CCR2-RA is a allosteric antagonist of chemokine (C-C motif) receptor 2 (CCR 2), and it can be used in cancer research.
    CCR2-RA
  • HY-13245A
    (s)-PF-4136309
    		Control 98.93%
    (s)-PF-4136309 is the isomer of PF-4136309 (HY-13245), and can be used as an experimental control. PF-4136309 is a potent, selective, and orally bioavailable CCR2 antagonist, with IC50s of 5.2 nM, 17 nM and 13 nM for human, mouse and rat CCR2.
    (s)-PF-4136309
  • HY-RS02154
    CCR3 Human Pre-designed siRNA Set A
    		Inhibitor

    CCR3 Human Pre-designed siRNA Set A contains three designed siRNAs for CCR3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    CCR3 Human Pre-designed siRNA Set A
  • HY-P991541
    HGS101
    		Ligand
    HGS101 is a fully human CCR5 monoclonal antibody with high affinity to CCR5. HGS101 binds to the 2nd extracellular loop (ECL-2) and acts as a signal antagonist. HGS101 restores Maraviroc (HY-13004) inhibition of Maraviroc-resistant HIV-1 infection of PBMCs. HGS101 shows anti-HIV activity by inhibiting CCR5 signaling in simian immunodeficiency virus-uninfected RMs models.
    HGS101
  • HY-B0155B
    Vicriviroc malate
    		Antagonist
    Vicriviroc (SCH 417690) malate is an orally active CCR5 antagonist with the IC50 of 10 nM, and also inhibts MIP-1α and intracellular calcium release induced by the ligand RANTES (10 nM) with the IC50 values of 0.91 nM and 16 nM,,respectively. Vicriviroc malate can inhibits human immunodeficiency virus type 1 (HIV-1) infection, and can also used for study of cancer.
    Vicriviroc malate
  • HY-176255
    TBK1 degrader-4
    		Inhibitor
    TBK1 degrader-4 (Compound 30) is a molecular glue degrader targeting TBK1. TBK1 degrader-4 effectively inhibits cyst growth, alleviates inflammation, and reduces the levels of pro-inflammatory factors such as Ccl2, IFNβ, and IL-6. TBK1 degrader-4 is promising for research of autosomal dominant polycystic kidney disease (ADPKD).
    TBK1 degrader-4
Cat. No. Product Name / Synonyms Species Source
Cat. No. Product Name / Synonyms Application Reactivity
CCR Isoform Comparison

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