2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-P3355
    p-fin4 2883747-74-6 98%
    p-fin4 is a peptide inhibitor of STEP Phosphatase-GluA2 AMPA receptor interaction with a Ki of 0.4 μM. p-fin4 restores the memory deficits and displays anxiolytic and antidepressant effects in a scopolamine-treated rat model. p-fin4 is a promising lead compound for novel cognitive enhancers and/or behavioral modulators.
    p-fin4
  • HY-P3376
    Riminkefon 2168572-99-2 98%
    Riminkefon is a kappa opioid receptor agonist.
    Riminkefon
  • HY-P3392
    Zilganersen 2305355-56-8
    Zilganersen (ION373) is a glial fibrillary acidic protein (GFAP) inhibitor, an antisense oligonucleotide. Zilganersen can be used in Alexander disease (AxD) research.
    Zilganersen
  • HY-P3414
    Proteasome-activating peptide 1 1565763-62-3 98%
    Proteasome-activating peptide 1 is a peptide, which increases the chymotrypsin-like proteasomal catalytic activity and, consequently, proteolytic rates both in vitro and in culture. Proteasome-activating peptide 1 prevents protein aggregation in a cellular model of amyotrophic lateral sclerosis.
    Proteasome-activating peptide 1
  • HY-P3445
    Anrikefon 2269511-95-5 98%
    Anrikefon (HSK21542) is a kappa opioid receptor agonist with analgesic effect.
    Anrikefon
  • HY-P3483
    Maxadilan 135374-80-0 98%
    Maxadilan is a specific irreversible PAC1 receptor agonist and a potent vasodilator peptide present in the salivary glands of sand flies. Maxadilan exhibits anti-apoptotic activity in hADSCs. Maxadilan inhibits pro-inflammatory cytokines (TNF-α) and enhances anti-inflammatory mediators (IL-10). Maxadilan can activate leukocytes and inhibit vascular permeability through PAC1 receptors. Maxadilan promotes neural differentiation of human adipose-derived stem cells. Maxadilan can be used to study endotoxin shock, atherosclerosis, and neurodegenerative diseases[1][2][3][4][5].
    Maxadilan
  • HY-P3515
    β-Lipotropin (61-69) 59481-79-7 98%
    β-Lipotropin (61-69) is a potent opioid agonist.
    β-Lipotropin (61-69)
  • HY-P3517
    β-Endorphin (6-31), human 77761-27-4 98%
    β-Endorphin, an endogenous opioid neuropeptide, is an opioid receptor agonist. β-Endorphin binds preferentially to μ-opioid receptors and is produced in certain neurons of the central and peripheral nervous system and is one of three endorphins produced in humans. β-Endorphin can be used to reduce stress and maintain homeostasis in the body and is involved in neurological pain perception regulation.
    β-Endorphin (6-31), human
  • HY-P3528
    GPR 47295-77-2 98%
    GPR is a three amino acid peptide. GPR can rescue cultured rat hippocampal neurons from Aβ-induced neuronal death by inhibiting caspase-3/p53 dependent apoptosis. GPR can be used for the research of Alzheimer's disease (AD).
    GPR
  • HY-P3539
    Exendin-4 (3-39) 196109-31-6 98%
    Exendin-4 (3-39) is a peptide. Exendin-4 (3-39) is a truncated form of Exendin-4 (HY-13443) that lacks the first two amino acids. Exendin-4 is a potent Glucagon-like peptide-1 receptor (GLP-1r) agonist. Exendin-4 (3-39) and Exendin-4 can be used for the research of diabetic and hypothalamic-pituitary-adrenal (HPA) axis.
    Exendin-4 (3-39)
  • HY-P3541
    Dirucotide 152074-97-0 98%
    Dirucotide (MBP8298) is a synthetic peptide that consists of 17 amino acids linked in a sequence identical to that of a portion of human myelin basic protein. Dirucotide can be used for the research in autoimmune disorder of the central nervous system, such as Multiple sclerosis (MS).
    Dirucotide
  • HY-P3546
    [DPen2, Pen5] Enkephalin 88373-72-2 98%
    [DPen2, Pen5] Enkephalin is a δ-opioid receptor selective analog of [Leu5]-Enkephalin (HY-P0288).
    [DPen2, Pen5] Enkephalin
  • HY-P3548
    [D-Ala2]-Met-Enkephalinamide 61090-95-7 98%
    [D-Ala2]-Met-Enkephalinamide, an opioid peptide, is a potent opioid agonist. [D-Ala2]-Met-Enkephalinamide decreases bile flow by a central mechanism. [D-Ala2]-Met-Enkephalinamide has analgesic properties.
    [D-Ala2]-Met-Enkephalinamide
  • HY-P3549
    [D-Ala2] Leu-Enkephalinamide 65189-64-2 98%
    [D-Ala2] Leu-Enkephalinamide is an enkephalin analog. [D-Ala2] Leu-Enkephalinamide has great corneal permeability and analgesic effect. [D-Ala2] Leu-Enkephalinamide can be used for the research of ocular diseases.
    [D-Ala2] Leu-Enkephalinamide
  • HY-P3550
    β-Lipotropin (60-65) 60117-19-3 98%
    β-Lipotropin (60-65) (β-LPH (60-65)), an opioid peptide, is a potent opioid agonist.
    β-Lipotropin (60-65)
  • HY-P3553
    Alsactide 34765-96-3 98%
    Alsactide, a heptadecapeptide analogue, is an adrenocorticotropic hormone (ACTH) agonist. Alsactide can be used in research of central nervous system.
    Alsactide
  • HY-P3561
    Agouti-related Protein (AGRP) (83-132) Amide (human) 98%
    Agouti-related Protein (AGRP) (83-132) Amide (human) is a fragment of agouti-related protein (AGRP) which is a protein found in abundance in the arcuate nucleus of the hypothalamus. AgRP primarily acts as an inverse agonist for the melanocortin-4 receptor (MC4R) to increase food intake.
    Agouti-related Protein (AGRP) (83-132) Amide (human)
  • HY-P3567
    (p-Iodo-Phe7)-ACTH (4-10) 159600-82-5 98%
    (p-Iodo-Phe7)-ACTH (4-10) is a adrenocorticotrophic hormone (ACTH) derivative, which is produced and secreted by the anterior pituitary gland. (p-Iodo-Phe7)-ACTH (4-10) serves as a melanocortin (MC) receptor antagonist and inhibits α-melanocyte-stimulating hormone (α-MSH)-induced excessive grooming behavior in rats.
    (p-Iodo-Phe7)-ACTH (4-10)
  • HY-P3576
    Biotin-Gastrin Releasing Peptide, human 98%
    Biotin-Gastrin Releasing Peptide, human is a biotinylated gastrin releasing peptide (GRP). Gastrin-releasing peptide (GRP) is a neuropeptide with growth-stimulatory and tumorigenic properties.
    Biotin-Gastrin Releasing Peptide, human
  • HY-P3591
    YMRF-NH2 83903-32-6 98%
    YMRF-NH2 is a neuropeptide. YMRF-NH2 binds to FMRFa-R with an EC50 value of 31 nM.
    YMRF-NH2
Cat. No. Product Name / Synonyms Application Reactivity