2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N15569
    Fendleryl B 2098405-74-2 98%
    Fendleryl B is a compound isolated from the extract of the edible mushroom Gambas edible mushroom. Fendleryl B can be used in the study of neurological diseases.
    Fendleryl B
  • HY-N15571
    Hedopeptolide 98%
    Hedopeptolide can be found in the marine cyanobacteria Okeania sp. Hedopeptolide inhibits LSP-induced NO production in RAW264.7 cells (IC50: 4 μM). Hedopeptolide exhibits anti-inflammatory activity.
    Hedopeptolide
  • HY-N15626
    Speciophylline 4697-68-1 98%
    Speciophylline (Uncarine D) is a pentacyclic indole alkaloid that can be extracted from cat's claw.
    Speciophylline
  • HY-N1570R
    Pterosin B (Standard) 34175-96-7
    Pterosin B (Standard) is the analytical standard of Pterosin B (HY-N1570). This product is intended for research and analytical applications. Pterosin B is an indanone. Pterosin B can be obtained from Pteridium aquilinum. Pterosin B is a Sik3 signaling inhibitor. Pterosin B inhibits Klf5 expression and reduces β-amyloid deposition. Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice. Pterosin B inhibits cardiomyocyte hypertrophy, improves cognitive impairment, and lowers blood glucose. Pterosin B can be used in research on arthritis, Alzheimer's disease, pathological cardiac hypertrophy and diabetes.
    Pterosin B (Standard)
  • HY-N15730
    3-Hydroxymycophenolic acid 172608-85-4 98%
    3-Hydroxymycophenolic acid (Compound 5) is a microbial transformation product of Mycophenolic acid (HY-B0421) by Cunninghamella echinulata. 3-Hydroxymycophenolic acid has low cytotoxicity against AGS cells and fibroblasts. 3-Hydroxymycophenolic acid can be used for immune-mediated renal diseases research.
    3-Hydroxymycophenolic acid
  • HY-N16632
    1-O-Caffeoylglycerol 123134-23-6
    1-O-Caffeoylglycerol is a compound with anti-inflammatory activity isolated from Sorghum bicolor. 1-O-Caffeoylglycerol significantly inhibits LPS (HY-D1056) induced NO production (IC50 = 18.5 μM) and dose dependently inhibits iNOS protein expression. 1-O-Caffeoylglycerol can be used for research on inflammatory conditions.
    1-O-Caffeoylglycerol
  • HY-N16639
    (+)-Catechin-3′-O-β-D-glucoside 105330-51-6 98%
    (+)-Catechin-3’-O-β-D-glucoside is a mono glucoside derivative of (+)-catechins after biotransformation. (+)-Catechin-3’-O-β-D-glucoside is a potential antioxidant.
    (+)-Catechin-3′-O-β-D-glucoside
  • HY-N16656
    Ladyginoside A 38424-95-2
    Ladyginoside A is a triterpenoid saponin found in the leaves of Polyscias fruticosa (L.) Harms. Ladyginoside A has inhibitory activities against α-amylase and α-glucosidase, and can regulate carbohydrate metabolism. Ladyginoside A also exhibits potential anti-inflammatory and mast cell stabilizing effects. Ladyginoside A can be used for the researches of inflammation and metabolic disease, such as diabetes.
    Ladyginoside A
  • HY-N1677R
    2,6-Dimethoxy-1,4-benzoquinone (Standard) 530-55-2
    2,6-Dimethoxy-1,4-benzoquinone, a natural phytochemical, is a known haustorial inducing factor. 2,6-Dimethoxy-1,4-benzoquinone exerts anti-cancer, anti-inflammatory, anti-adipogenic, antibacterial, and antimalaria effects.
    2,6-Dimethoxy-1,4-benzoquinone (Standard)
  • HY-N1939R
    Icariside I (Standard) 56725-99-6
    Icariside I (Standard) is the analytical standard of Icariside I (HY-N1939). This product is intended for research and analytical applications. Icariside I (GH01) is an orally active metabolite of icalin. Icariside I improves estrogen deficiency-induced osteoporosis by simultaneously regulating osteoblast and osteoclast differentiation. Icariside I promotes ATP (HY-B2176) or Nigericin (HY-127019)-induced mtROS production and NLRP3 inflammasome activation and causes idiosyncratic hepatotoxicity. Icariside I does not alter the activation of NLRC4 and AIM2 inflammasomes. Icariside I inhibits breast cancer proliferation, apoptosis, invasion, and metastasis by targeting the IL-6/STAT3 pathway. Icariside I is a kynurenine-AhR pathway inhibitor that alleviates cancer by blocking tumor immune escape.
    Icariside I (Standard)
  • HY-N1949R
    Homoplantaginin (Standard) 17680-84-1
    Homoplantaginin (Standard) is the analytical standard of Homoplantaginin. This product is intended for research and analytical applications. Homoplantaginin is a flavonoid from a traditional Chinese medicine Salvia plebeia with antiinflammatory and antioxidant properties. Homoplantaginin could inhibit TNF-α and IL-6 mRNA expression, IKKβ and NF-κB phosphorylation.
    Homoplantaginin (Standard)
  • HY-N1965R
    Gaultherin (Standard) 490-67-5
    Gaultherin (Standard) is the analytical standard for Gaultherin (HY-N1965). Gaultherin is an orally active non-steroidal anti-inflammatory agent. Gaultherin selectively inhibits NF-κB, MAPK, COX-2 (IC50 = 0.35 mg/mL), LOX (IC50 = 0.56 mg/mL) and HYAL (IC50 = 28.58 μg/mL) to exert anti-inflammatory, antipyretic and analgesic effects. Gaultherin exhibits modest direct antioxidant capacity, greater in cell-based models. Gaultherin does not affect COX-1 so that avoids the common gastrointestinal side effects of Aspirin (HY-14654).
    Gaultherin (Standard)
  • HY-N1973R
    Sennoside D (Standard) 37271-17-3
    Sennoside D (Standard) is the analytical standard of Sennoside D. This product is intended for research and analytical applications. Sennoside D is an anthraquinone glycoside, found in leaves and pods of Senna (Cassia angustifolia).
    Sennoside D (Standard)
  • HY-N1980R
    3'-Hydroxypuerarin (Standard) 117060-54-5
    3'-Hydroxypuerarin (Standard) is the analytical standard of 3'-Hydroxypuerarin. This product is intended for research and analytical applications. 3'-Hydroxypuerarin is an isoflavone isolated from the roots of Pueraria lobata (Willd.) Ohwi. 3'-Hydroxypuerarin is a antioxidant, which shows marked ONOO(-), NO?, total ROS scavenging activities.
    3'-Hydroxypuerarin (Standard)
  • HY-N1996R
    Chebulagic acid (Standard) 23094-71-5
    Chebulagic acid (Standard) is the analytical standard of Chebulagic acid. This product is intended for research and analytical applications. Chebulagic acid is a COX-LOX dual inhibitor isolated from the fruits of Terminalia chebula Retz, on angiogenesis. Chebulagic acid is a M2 serine to asparagine 31 mutation (S31N) inhibitor and influenza antiviral. Chebulagic acid also against SARS-CoV-2 viral replication with an EC50 of 9.76 μM.
    Chebulagic acid (Standard)
  • HY-N2006R
    Ganoderic acid B (Standard) 81907-61-1
    Ganoderic acid B (Standard) is the analytical standard of Ganoderic acid B. This product is intended for research and analytical applications. Ganoderic acid B is a triterpene isolated from a mushroom Ganoderma lucidum. Ganoderic acid B inhibits the activation of Epstein-Barr virus (EBV) antigens as telomerase inhibitor. Ganoderic acid B is a moderately active inhibitor against HIV-1 protease (IC50: 170 μM).
    Ganoderic acid B (Standard)
  • HY-N2007R
    Veratric acid (Standard) 93-07-2 99.99%
    Veratric acid (Standard) is the analytical standard of Veratric acid. This product is intended for research and analytical applications. Veratric acid (3,4-Dimethoxybenzoic acid) is an orally active phenolic compound derived from vegetables and fruits, has antioxidant and anti-inflammatory activities. Veratric acid also acts as a protective agent against hypertension-associated cardiovascular remodelling. Veratric acid reduces upregulated COX-2 expression, and levels of PGE2, IL-6 after UVB irradiation.
    Veratric acid (Standard)
  • HY-N2013R
    Aristolactam I (Standard) 13395-02-3
    Aristolactam I (Standard) is the analytical standard of Aristolactam I. This product is intended for research and analytical applications. Aristolactam I is an AQP1 inhibitor and Aristolochic acid I metabolite. Aristolactam I can be isolated from Aristolochia plants. Aristolactam I downregulates Twist1 expression, increases E-cadherin expression, and activates the TGF-β/Smad signaling pathway. Aristolactam I has anticancer activity against breast cancer. Aristolactam I is nephrotoxic. Aristolactam I is mainly used in the study of breast cancer and kidney diseases such as renal interstitial fibrosis.
    Aristolactam I (Standard)
  • HY-N2014R
    Verbenalin (Standard) 548-37-8
    Verbenalin (Standard) is the analytical standard of Verbenalin. This product is intended for research and analytical applications. Verbenalin is an orally active terpenoid glycoside that can be extracted from the medicinal plant Verbena officinalis. Verbenalin has anti-inflammatory, antiviral, and neuroprotective effects. Verbenalin has a strong binding affinity to the nsp-12 protein of the SARS-CoV-2 virus. Verbenalin can be used in the research of inflammatory and nervous system diseases such as hepatitis and Alzheimer's disease.
    Verbenalin (Standard)
  • HY-N2022R
    Castanospermine (Standard) 79831-76-8
    Castanospermine is a natural alkaloid that can be extracted from black beans or the Moreton Bay chestnut tree (Castanospermum australae). Castanospermine is an α/ β-glucosidase inhibitor. Castanospermine has anti-inflammatory, antiviral replication and anti-metastatic effects on prostate cancer. Castanospermine can be used as an immunosuppressant to prevent transplant rejection.
    Castanospermine (Standard)
Cat. No. Product Name / Synonyms Application Reactivity