2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-124896
    Bonannione A 97126-57-3 98%
    Bonannione A (6-Geranylnaringenin; Mimulone), a prenylflavonoid, is an orally active and potent protein tyrosine phosphatase 1B (PTP1B) inhibitor with an IC50 of 14 µM. Bonannione A triggers caspase-dependent apoptosis. Bonannione A induces autophagy through p53-mediated AMPK/mTOR pathway. Bonannione A shows anti-inflammatory, antiradical and anti-cancer activity.
    Bonannione A
  • HY-124941
    7-Deacetylgedunin 10314-90-6 98%
    7-Deacetylgedunin is an activator of Keap1/Nrf2/HO-1. 7-Deacetylgedunin alleviates mice mortality induced by LPS. 7-Deacetylgedunin inhibits Keap1 expression and suppresses macrophage proliferation. 7-Deacetylgedunin suppresses inflammation in vivo and in vitro.
    7-Deacetylgedunin
  • HY-124954
    MN-25 501926-82-5 98%
    MN-25 (compound 4a) is an orally active indolpyridone that serves as a novel cannabinoid ligand. MN-25 has Ki of 245 nM and 11 nM for CB1 and CB2. MN-25 has CB2 agonist activity and inhibits TNF-R release in human peripheral blood mononuclear cells in vitro with an IC50 of 33 μM. MN-25 shows efficacy in a mouse acute inflammation model at oral doses up to 50 mg/kg>[1].
    MN-25
  • HY-124987
    MRS4458 2225834-49-9 98%
    MRS4458 is a P2Y14 receptor antagonist with anti-inflammatory activity. MRS4458 mediates inflammatory activity by activating the motility of neutrophils. The design of MRS4458 is based on the interaction with the P2Y14 receptor and optimized by molecular dynamic simulation. MRS4458 performs well in terms of shape and complementarity with the receptor. The prediction that the 5-phenyl group of MRS4458 is substituted with thiophene is generally consistent with empirical results. The biological activity of MRS4458 was verified by fluorescence assay, showing its potent antagonistic effect.
    MRS4458
  • HY-124995
    BMS-986126 1610017-20-3 98%
    BMS-986126 is a potent, selective, and orally active IRAK4 inhibitor (IC50 = 5.3 nM). BMS-986126 broadly inhibits MyD88-dependent signaling pathways. BMS-986126 demonstrates robust activity in the MRL/lpr and NZB/NZW murine models of lupus, inhibiting multiple pathogenic responses. BMS-986126 can be used for autoimmune diseases research, such as lupus erythematosus (SLE).
    BMS-986126
  • HY-125020
    NCGC00135472 862811-76-5 98%
    NCGC00135472 is a potent agonist of resolvin D1 receptor (DRV1), with the EC50 of 0.37 nM and 0.05 μM for β-arrestin and cAMP activities, respectively.
    NCGC00135472
  • HY-125050
    KCA-1490 909719-71-7 98%
    KCA-1490 is a dual PDE3/4 inhibitor with IC50 values of 369 nM and 42 nM, respectively. KCA-1490 exhibits potent bronchodilatory and anti-inflammatory activity. KCA-1490 suppresses Histamine (HY-B1204)-induced bronchoconstriction in vivo, which is promising for research of asthma and chronic obstructive pulmonary disease (COPD).
    KCA-1490
  • HY-125082
    SB 204144 141396-10-3 98%
    SB 204144 is an HIV protease inhibitor. SB 204144 can be used in research on immune system diseases.
    SB 204144
  • HY-125122
    Mulberrofuran A 68978-04-1 98%
    Mulberrofuran A is a natural product, that can be isolated from the root bark of mulberry tree. Mulberrofuran A inhibits the formations of 12-hydroxy-,8,10-heptadecatrienoic acid (HHT) and thromboxane B2 (cyclooxygenase products), but it increases the formation of 12-hydroxy-5,8,10,14-eicosatetraenoic acid (12-HETE) (12-lipoxygenase product).
    Mulberrofuran A
  • HY-125131
    Buddlejasaponin IV 139523-30-1 98%
    Buddlejasaponin IV (BS‐IV) exerts anti-inflammatory and cytotoxic effects against cancer cells.
    Buddlejasaponin IV
  • HY-125134
    Alloaromadendrene 25246-27-9 98%
    Alloaromadendrene, an antioxidant, can be isolated from the leaves of mixed-type C. osmophloeum. Alloaromadendrene protects C. elegans against oxidative stress induced by walnut quinone and prolongs the life of C. elegans.
    Alloaromadendrene
  • HY-125141
    δ-CEHC 84599-16-6
    δ-CEHC is a δ-tocopherol (HY-113026) metabolite. δ-CEHC has antioxidant activity.
    δ-CEHC
  • HY-125157
    Me-Indoxam 172732-62-6 98%
    Me-Indoxam is a potent and cell-impermeable secreted phospholipase A2 (sPLA2) inhibitor.
    Me-Indoxam
  • HY-125197
    BRD5631 2446154-91-0 98%
    BRD5631 is an autophagy enhancer, enhances autophagy through an mTOR-independent pathway. BRD5631 affects several cellular disease phenotypes previously linked to autophagy, including protein aggregation, cell survival, bacterial replication, and inflammatory cytokine production.
    BRD5631
  • HY-125201
    Indazole 1 2252153-37-8 98%
    Indazole 1 is a potent CDC2-like kinase 2 (CLK2) inhibitor (IC50=12.3 nM). Indazole 1 inhibits the phosphorylation of SR proteins (e.g., SRSF1, SRSF3) and modulates alternative splicing of Wnt signaling-related genes. Indazole 1 is promising for research of osteoarthritis.
    Indazole 1
  • HY-125251
    D159153 1158231-00-5 98%
    D159153 is a highly selective phosphodiesterase 4 (PDE4) inhibitor. D159153 is promising for research of asthma, chronic obstructive pulmonary disease (COPD), and neuroinflammatory disorders.
    D159153
  • HY-125279
    OAT-2068 2221950-65-6 98%
    OAT-2068 is a selective, high activity and orally active inhibitor of mouse chitotriosidase (mCHIT1) (IC50=29 nM) and displays 143-fold selectivity over m AMCase (IC50=4170 nM). OAT-2068 displays a good pharmacokinetic profile and is an ideal tool to study the role of CHIT1 in biological systems, including animal models of human diseases.
    OAT-2068
  • HY-125301
    Thymoctonan 107489-37-2 98%
    Thymoctonan (THF-γ2) is the immunomodulatory octapeptide, thymic humoral factor γ2. Thymoctonan has the half-life less than 6 min at 37 °C in blood from human, rat and mouse.
    Thymoctonan
  • HY-125313
    PSB-1737 139896-80-3 98%
    PSB-1737 is a human-selective GPR17 agonist with an EC50 for human GPR17 of 27 nM, and its activity on murine GPR17 is relatively weak (EC50 > 10 μM). PSB-1737 shows no significant inhibition at the glycine binding site of NMDA receptors, and has no significant agonistic or antagonistic activity on P2Y receptor subtypes. PSB-1737 can be used in demyelinating diseases (such as multiple sclerosis) or inflammatory-related anemia.
    PSB-1737
  • HY-125360
    Mazipredone free base 13085-08-0 98%
    Mazipredone free base, a glucocorticoid derivative, is an anti-inflammatory and anti-allergic agent. Mazipredone free base is sensitive to oxidation, acidic and basic media.
    Mazipredone free base
Cat. No. Product Name / Synonyms Application Reactivity