2. Cell Cycle/DNA Damage
  3. CDK
  4. Indazole 1

Indazole 1 is a potent CDC2-like kinase 2 (CLK2) inhibitor (IC50=12.3 nM). Indazole 1 inhibits the phosphorylation of SR proteins (e.g., SRSF1, SRSF3) and modulates alternative splicing of Wnt signaling-related genes. Indazole 1 is promising for research of osteoarthritis.

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Indazole 1

Indazole 1 Chemical Structure

CAS No. : 2252153-37-8

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Indazole 1 Related Antibodies

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Description

Indazole 1 is a potent CDC2-like kinase 2 (CLK2) inhibitor (IC50=12.3 nM). Indazole 1 inhibits the phosphorylation of SR proteins (e.g., SRSF1, SRSF3) and modulates alternative splicing of Wnt signaling-related genes. Indazole 1 is promising for research of osteoarthritis[1].

IC50 & Target

CLK2

 

Molecular Weight

324.42

Formula

C19H24N4O
CAS No.
SMILES

CC(C)C[C@H](N)COC1=CC(C2=CC3=C(NN=C3C)C=C2)=CN=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Indazole 1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Indazole 12252153-37-8Indazole1Indazole-1CDKCyclin dependent kinaseCLK2SRSF1SRSF3osteoarthritisInhibitorinhibitorinhibit

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