2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

Related Products

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-124099
    SCH 40120 110545-79-4 98%
    SCH 40120 is a potent leukotriene inhibitor with antiinflammatory effects. SCH 40120 suppresses T cell proliferative responses, antigen-specific and poly-clonally-induced in vitro antibody responses. SCH 40120 suppresses an edematous response and inhibits the recruitment of circulating neutrophils into sites of inflammation. SCH 40120 is proming for rasearch of anti-psoriatic agents.
    SCH 40120
  • HY-124153
    GNE-431 1433820-83-7 98%
    GNE-431 is a potent, selective and noncovalent “pan-BTK” inhibitor against C481R, T474I and T474Ms mutants. GNE-431 shows potency against wild-type BTK (IC50= 3.2 nM) and potency against C481S mutant (IC50= 2.5 nM). GNE-431 is proming for rasearch of haematological disorders and autoimmune diseases.
    GNE-431
  • HY-124240
    SRTCX1003 1203480-86-7 98%
    SRTCX1003 is an orally active SIRT1 activator. SRTCX1003 suppresses inflammatory responses.
    SRTCX1003
  • HY-124241
    N-Cyclopropyl bimatoprost 1138395-12-6 98%
    N-Cyclopropyl bimatoprost (Formula II), a prostaglandin analog, can be used in the study of epithelial-related conditions.
    N-Cyclopropyl bimatoprost
  • HY-124270
    Sibenadet hydrochloride 154189-24-9 98%
    Sibenadet hydrochloride (AR-C68397AA) is a dual D2 dopamine receptor, beta2-adrenoceptor agonist with bronchodilator activity. Investigation in animal models of key chronic obstructive pulmonary disease (COPD) symptoms has demonstrated that Sibenadet hydrochloride effectively inhibits sensory nerve activity, thereby reducing reflex cough, mucus production and tachypnoea.
    Sibenadet hydrochloride
  • HY-124283
    LEI-101 free base 1228660-00-1 98%
    LEI-101 free base is a selective and orally bioavailable CB2 receptor agonist with the potential to inhibit diseases associated with inflammation and/or oxidative stress. LEI-101 free base has a binding potency to CB2 receptors that is approximately 100 times higher than that to CB1 receptors. Its pEC50 value on CB2 receptors is 8, while its pKi value on hERG is less than 4. LEI-101 may have an inhibitory effect on conditions such as kidney disease.
    LEI-101 free base
  • HY-124286
    N-cis-Tetradec-9Z-enoyl-L-homoserine lactone 1675245-06-3 98%
    N-cis-Tetradec-9Z-enoyl-L-homoserine lactone (C14-9Z-HSL) is an autoinducer in C. rodentium, that serves as signal molecule, coordinates the gene expression and behaviors through diffusion into cells of different bacterial species.
    N-cis-Tetradec-9Z-enoyl-L-homoserine lactone
  • HY-124345
    2-Trifluoromethyl-2'-methoxychalcone 1309371-03-6 98%
    2-Trifluoromethyl-2'-methoxychalcone is a chalcone derivative. 2-Trifluoromethyl-2'-methoxychalcone is a potent Nrf2 activator. 2-Trifluoromethyl-2'-methoxychalcone can be used for oxidative stress and inflammation related diseases research.
    2-Trifluoromethyl-2'-methoxychalcone
  • HY-124356
    Alcaftadine carboxylic acid 147083-93-0 98%
    Alcaftadine carboxylic acid is a broad-spectrum antihistamine compound with high affinity for histamine H1 and H2 receptors and low affinity for H4 receptors. Alcaftadine carboxylic acid has also demonstrated effects on modulating immune cell recruitment and stabilizing mast cells. Alcaftadine carboxylic acid is more effective than placebo in preventing ocular itching associated with allergic conjunctivitis and is at least as effective as olopatadine 0.01%.
    Alcaftadine carboxylic acid
  • HY-124378
    MAGL-IN-17 1643657-35-5 98%
    MAGL-IN-17 (Compound ) is an inhibitor for MAGL with a Ki of 0.4 μM. MAGL-IN-17 inhibits mouse MAGL and rat MAGL with IC50 of 0.18 and 0.24 μM. MAGL-IN-17 exhibits anti-inflammatory activity in mouse experimental autoimmune encephalitis models.
    MAGL-IN-17
  • HY-124388
    PDE4-IN-20 1396397-03-7 98%
    PDE4-IN-20 is a selective submicromolar phosphodiesterase-4 (PDE4) inhibitor with anti-TNF-α properties. PDE4-IN-20 exhibits significant biological activity in vitro and in vivo. The mechanism of action of PDE4-IN-20 is supported by molecular modeling studies, which reveal its binding mode with PDE4. PDE4-IN-20 was optimized in further conformational analysis and showed pharmacological characteristics similar to those of known PDE4 inhibitors.
    PDE4-IN-20
  • HY-124556
    Elasnin 68112-21-0 98%
    Elasnin is a selective granulocyte elastase inhibitor. Elasnin is almost ineffective for pancreatic elastase, trypsin, chymotrypsin, thermolysin and papain.
    Elasnin
  • HY-124557
    Mahanimbine 21104-28-9 98%
    Mahanimbine is an orally active alkaloid from Murraya koenigii. Mahanimbine inhibits progression of high-fat diet (HFD)-induced metabolic complications in mice.
    Mahanimbine
  • HY-124635
    BC-54 534579-04-9 98%
    BC-54 is a selective inhibitor of enzymes from the cAMP-specific PDE4 and PDE7 families. BC-54 displays potent anti-inflammatory properties and can induce cancer cells apoptosis. BC-54 can be used for the researches of cancer and inflammation, such as chronic lymphocytic leukemia.
    BC-54
  • HY-124655
    S1PL-IN- 2 1897406-94-8 98%
    S1PL-IN-2 (Compound 28) is a potent sphingosine-1-phosphate lyase (S1PL) inhibitor with an IC50 of 120 nM. S1PL-IN-2 shows an IC50 of 230 nM on HEK293 cells. S1PL-IN-2 block the conversion of Vitamin B6 into the active pyridoxal-4-phosphate cofactor required for S1P lyase activity. S1PL-IN-2 can be used for the researches of inflammation and immunology, such as rheumatoid arthritis.
    S1PL-IN- 2
  • HY-124665
    LMP-420 473870-63-2 98%
    LMP-420 is a selective tumor necrosis factor-α (TNF-α) inhibitor. LMP-420 reduces the release of pro-inflammatory cytokines (e.g., IL-1β, IL-2), inducing the expression of anti-inflammatory cytokine IL-10 and anti-apoptotic molecules SOCS-1 and Mn-SOD. LMP-420 also downregulates chemokines (e.g., IP-10, MCP-1) to reduce immune cell infiltration. LMP-420 is promising for research of type 1 diabetes mellitus, inflammatory diseases (e.g., colitis), and HIV-Mycobacterium tuberculosis coinfection.
    LMP-420
  • HY-124668
    CCR1 antagonist 12 921208-19-7 98%
    CCR1 antagonist 12 (Compound 12) is an antagonist for CCR1 with IC50 of 3 nM for human CCR1. CCR1 antagonist 12 inhibits CCL3-induced transwell chemotaxis with an IC50 of 0.009 µM. CCR1 antagonist 12 exhibits good pharmacokinetic characters in rats model.
    CCR1 antagonist 12
  • HY-124748
    ENMD-1068 789488-77-3 98%
    ENMD-1068 is a selective protease-activated receptor 2 (PAR2) antagonist. ENMD-1068 reduces hepatic stellate cell activation and collagen expression by inhibiting TGF-β1/Smad signaling. ENMD-1068 also inhibits the proliferation of endometrial cells and induces apoptosis of epithelial cells in the lesion. ENMD-1068 can be used in the study of endometriosis and liver fibrosis.
    ENMD-1068
  • HY-124852
    ZPL-5212372 916136-25-9 98%
    ZPL-5212372 (PF 5212372) is a cPLA2α inhibitor (IC50 = 7 nM). ZPL-5212372 inhibits the release of prostaglandin D2 (PGD2), cysteyl leukotrienes, leukotriene B4, thromboxane A2, and PGD2 from human lung cells. ZPL-5212372 inhibits delayed bronchoconstriction and airway hyperresponsiveness in a sheep allergic inflammation model. ZPL-5212372 may be used in asthma research.
    ZPL-5212372
  • HY-124857
    7DG 26927-01-5 98%
    7DG (7-Desacetoxy-6,7-dehydrogedunin) is a protein kinase R (PKR) inhibitor. 7DG protects macrophages from lethal toxin-induced pyroptosis.
    7DG
Cat. No. Product Name / Synonyms Application Reactivity