2. Metabolic Enzyme/Protease GPCR/G Protein
  3. Phospholipase Prostaglandin Receptor Leukotriene Receptor
  4. ZPL-5212372

ZPL-5212372 (PF 5212372) is a cPLA2α inhibitor (IC50 = 7 nM). ZPL-5212372 inhibits the release of prostaglandin D2 (PGD2), cysteyl leukotrienes, leukotriene B4, thromboxane A2, and PGD2 from human lung cells. ZPL-5212372 inhibits delayed bronchoconstriction and airway hyperresponsiveness in a sheep allergic inflammation model. ZPL-5212372 may be used in asthma research.

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ZPL-5212372

ZPL-5212372 Chemical Structure

CAS No. : 916136-25-9

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ZPL-5212372 Related Antibodies

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Description

ZPL-5212372 (PF 5212372) is a cPLA2α inhibitor (IC50 = 7 nM). ZPL-5212372 inhibits the release of prostaglandin D2 (PGD2), cysteyl leukotrienes, leukotriene B4, thromboxane A2, and PGD2 from human lung cells. ZPL-5212372 inhibits delayed bronchoconstriction and airway hyperresponsiveness in a sheep allergic inflammation model. ZPL-5212372 may be used in asthma research[1].

Molecular Weight

823.34

Formula

C42H38ClF3N2O6S2
CAS No.
SMILES

O=C(O)CCC1=CC=C(S(=O)(CCC2=C(CCNS(=O)(CC3=CC=CC=C3C(F)(F)F)=O)N(C(C4=CC=CC=C4)C5=CC=CC=C5)C6=C2C=C(Cl)C=C6)=O)C=C1
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ZPL-5212372 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ZPL-5212372916136-25-9PF 5212372ZPL5212372ZPL 5212372PF5212372PF-5212372PhospholipaseProstaglandin ReceptorLeukotriene ReceptorcPLA2α inhibitorhuman lung cellssheep allergic inflammation modelasthmaInhibitorinhibitorinhibit

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