2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

Related Products

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-122292
    Celastramycin A 188988-62-7 98%
    Celastramycin A is an antibiotic isolated from Streptomyces MaB-QuH-8, which exhibits antimicrobial activity against series of gram-negative bacteria and mycobacteria, with MICs between 0.05-3.1 μg/ml. Celastramycin A exhibits immunosuppressing efficacy in ex vivo Drosophila through immune deficiency pathway (IC50 of 0.008 μg/ml), inhibits the immunoresponse in human innate immunity through TNF-α signaling, inhibits IL-8 production in HUEVCs with IC50 of 0.06 μg/ml.
    Celastramycin A
  • HY-122384
    Alcindoromycin 72586-21-1 98%
    Alcindoromycin is an anthracycline antitumor antibiotic.
    Alcindoromycin
  • HY-12238G
    IWR-1 (GMP) 1127442-82-3 98%
    IWR-1 (IWR-1-endo) (GMP) is the IWR-1 (HY-12238) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. IWR-1 (IWR-1-endo) is a tankyrase inhibitor targeting Wnt/β-catenin (IC50 = 180 nM). IWR-1 compromises critical steps of the canonical Wnt signaling, namely translocation of β-catenin to the nucleus and subsequent TCF/LEF activation and expression of Wnt/β-catenin downstream targets. IWR-1 promotes β-catenin phosphorylation by promoting stability of Axin-scaffolded destruction complexes. IWR-1 can be studied in research for anti-tumor purposes, and diseases such as osteosarcoma, colorectal cancer and psoriasis.
    IWR-1 (GMP)
  • HY-122437
    Quinuronium disulfate 135-14-8 98%
    Quinuronium disulfate, a babesicidal agent, possesses anticholinesterase activity.
    Quinuronium disulfate
  • HY-122483
    Diethyl pyimDC 1821370-64-2 98%
    iethyl pyimDC is a collagen prolyl 4-hydroxylase (CP4H1) inhibitor inhibitor with the IC50 of 2.6μM. Diethyl pyimDC can be used for study of antifibrotic and antimetastatic.
    Diethyl pyimDC
  • HY-122518
    8-Deazafolic acid 51989-25-4 98%
    8-Deazafolic acid is an antimicrobial drug for the folate-dependent bacteria, Streptococcus faecium (ATCC 8043) and Lactobacillus casei (ATCC 74691). 8-Deazafolic acid has activity against lymphoid leukemia L1210 in mice.
    8-Deazafolic acid
  • HY-122521
    Sootepin D 1154518-97-4 98%
    Sootepin D (compound 6), a triterpene from the apical bud of Gardenia sootepensis, inhibits TNF-α-induced NF-κB activity with an IC50 of 8.3μM. Sootepin D has anti-inflammatory activity.
    Sootepin D
  • HY-122655
    HMCEF 2002363-68-8 98%
    HMCEF is an orally active P-selectin inhibitor and inhibits P-selectin expression. HMCEF blocks the interaction between P-selectin and natural ligands, such as PSGL-1. HMCEF inhibits thrombosis and inflammation in mice.
    HMCEF
  • HY-122704
    Surfen 3811-56-1 98%
    Surfen is a potent heparan sulfate antagonist. Surfen inhibits FGF2 binding and signal transduction. Surfen binds to glycosaminoglycans and reduces tau hyperphosphorylation. Surfen inhibits the activity of recombinant uronyl 2-O-sulfotransferase with an IC50 of approximately 2 μM. Surfen inhibits HSV-1 viral infection. Surfen inhibits neural differentiation, delays remyelination, and alleviates EAE.
    Surfen
  • HY-122767
    Romurtide 78113-36-7 98%
    Romurtide (Muroctasin), a synthetic muramyl dipeptide derivative, is a cytokines inducer. Romurtide can increase peripheral neutrophils and monocytes in vivo and enhance production of colony-stimulating factors (CSFs), IL-1 and IL-6 in vitro.
    Romurtide
  • HY-122769
    Adapiprazine 57942-72-0 98%
    Adapiprazine is a methyl-replaced Prochlorperazine, which has immunosuppressive and anesthetic effects.
    Adapiprazine
  • HY-122772
    (-)-Integerrimine 480-79-5 98%
    (-)-Integerrimine, a pyrrolizidine alkaloid, has antiulcerogenic activity. (-)-Integerrimine is also a mutagenic and weakly clastogenic agent in Drosophila.
    (-)-Integerrimine
  • HY-122822
    GSK699 2260944-68-9 98%
    GSK699 is a PCAF/GCN5 PROTAC degrader. GSK699 promotes the ubiquitination and degradation of PCAF/GCN5. GSK699 inhibits the production of cytokines/chemokines (e.g., IL-6, CXCL1/GROα). GSK699 can be used in the research of inflammatory diseases (target protein ligand: HY-101027, CRBN ligand: HY-103596).
    GSK699
  • HY-12290A
    Arg-Gly-Asp-Ser TFA 98%
    Arg-Gly-Asp-Ser (TFA) is an integrin binding sequence that inhibits integrin receptor function. Arg-Gly-Asp-Ser (TFA) directly and specifically bind pro-caspase-8, pro-caspase-9 and pro-caspase-3, while it does not bind pro-caspase-1.
    Arg-Gly-Asp-Ser TFA
  • HY-122916
    7-Acetyllycopsamine 73544-48-6 98%
    7-Acetyllycopsamine, a pyrrolizidine alkaloid, is a mild hepatotoxin. 7-Acetyllycopsamine can induce liver inflammation in mice.
    7-Acetyllycopsamine
  • HY-122953
    Daturaolone 41498-80-0 98%
    Daturaolone is a natural triterpenoid with anti-inflammatory and antinociceptive potentials. Daturaolone displays a COX-1 inhibitory activity.
    Daturaolone
  • HY-122961
    Dehydromiltirone 116064-77-8 98%
    Dehydromiltirone (1,2-Didehydromiltirone) is a diterpenoid quinone with an anti-inflammatory effect. Dehydromiltirone prevents liver injury by modifying the MAPK and NF-κB signaling pathways, reducing neuroinflammatory responses, and inhibiting platelet aggregation. Dehydromiltirone can be used for osteoporosis research.
    Dehydromiltirone
  • HY-122970
    1,2-Dihydrotanshinone 77769-21-2 98%
    1,2-Dihydrotanshinone (1,2-Dihydrotanshinquinone) is an abietane diterpene. 1,2-Dihydrotanshinone inhibits the formation of the pathogenic complex formed between (CUG)n-RNA and the splicing-factor muscleblind-like 1 (MBNL1). 1,2-Dihydrotanshinone can be used for the research of myotonic dystrophy type 1.
    1,2-Dihydrotanshinone
  • HY-123013
    Y 9000 53944-40-4 98%
    Y 9000 is an orally active anti-allergic agent .
    Y 9000
  • HY-123025
    Schizozygine 2047-63-4 98%
    Schizozygine is an alkaloid that can be isolated from Schizozygia caffaeoides. Schizozygia caffaeoides has been used as a traditional medicine for skin disease. The leaf extracts has high antifungal and antimicrobial activity.
    Schizozygine
Cat. No. Product Name / Synonyms Application Reactivity