2. Endocrinology

Endocrinology

Endocrinology

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Found in most species of the animal kingdom, the endocrine system consists of glands that secrete hormones, and receptors that detect and react to the hormones. In response to environmental stimuli, the endocrine system secretes hormones and uses them as chemical messengers to orchestrate physiological, developmental and reproductive changes that affect the entire body for a long period of time. In order to maintain the proper functioning of the body through its entire life cycle, the endocrine system utilizes a complex feedback mechanism to fine-tune the balance of hormones in the bloodstream. Even a slight disruption to endocrine system’s function can throw off the delicate balance of hormones in the human body and lead to an endocrine disorder, or endocrine disease, such as diabetes, adrenal insufficiency, hyper- or hypothyroidism, and polycystic ovary syndrome (PCOS).

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-P10013
    Codactide 22572-04-9 98%
    Codactide is a synthetic octadecapeptide, with corticotropin-like action.
    Codactide
  • HY-P10015
    Orenetide 1124168-43-9 98%
    Orenetide is an innovative peptide drug developed in the study to restore sexual desire and concomitant functions in women with HSDD (Hypoactive desire disorder)
    Orenetide
  • HY-P10034
    Pheromonotropin (pseudaletia separata) 141281-40-5 98%
    Pheromonotropin (Pseudaletia separata) (Pss-PT) is an armyworm (Pseudaletia separata) pheromone with the C-terminal pentapeptide FXPRL-amide. Pheromonotropin (Pseudaletia separata) belongs to the PK/PBAN family and stimulates sex pheromone biosynthesis in moths, mediating feeding (intestinal muscle contraction), development (embryonic diapause, pupal diapause, and pupation), and defense against natural enemy insects wait.
    Pheromonotropin (pseudaletia separata)
  • HY-P1019A
    [Ala1,​3,​11,​15]​-​Endothelin (53-63) (TFA) 98%
    [Ala1,3,11,15]-Endothelin (53-63) (TFA) is an ETB agonist. [Ala1,3,11,15]-Endothelin (53-63) (TFA) has selectivity for ETB with IC50 values range from 0.33 nM to 0.61 nM. [Ala1,3,11,15]-Endothelin (53-63) (TFA) can be used for the research of vasoconstriction.
    [Ala1,​3,​11,​15]​-​Endothelin (53-63) (TFA)
  • HY-P10248
    Atriopeptin I (rat, mouse) 89139-53-7 98%
    Atriopeptin I rat, mouse is an atrial natriuretic peptide, which stimulates the testosterone production with half-maximum stimulation of 38 nM.
    Atriopeptin I (rat, mouse)
  • HY-P10256
    Kiss2 peptide 1111070-93-9 98%
    Kiss2 peptide is a positive regulator of reproduction. Kiss2 peptide binds with its cognate receptor Kiss2R (GPR54) in COS-7 cells, activates PKA and PKC signaling pathways through Gas and Gaq proteins, and thus enhances the activity of cAMP response element-dependent luciferase (CRE-luc) and serum response element-dependent luciferase (SRE-luc).
    Kiss2 peptide
  • HY-P10277
    Palopegteriparatide 2222514-07-8 98%
    Palopegteriparatide (Transcon PTH) is a prodrug of parathyroid hormone PTH 1-34, which can maintain normal and stable calcium concentrations without the need for calcium and active vitamin D replacement. Palopegteriparatide can be used in research on hypoparathyroidism.
    Palopegteriparatide
  • HY-P10278
    Anantin 133658-45-4 98%
    Anantin binds competitively to the receptor of atrial natriuretic factor (ANF) from bovine adrenal cortex (Kd = 0.6 μM) and acts as natriuretic peptide receptor A antagonist.
    Anantin
  • HY-P10309
    [Nle8,18,Tyr34]-pTH (3-34) amide (human) 120527-89-1 98%
    [Nle8,18,Tyr34]-pTH (3-34) amide human ([Nle8,18,Tyr34]hPTH (3-34) amide) is a parathyroid hormone (PTH) analog.
    [Nle8,18,Tyr34]-pTH (3-34) amide (human)
  • HY-P10318
    SHR-2042 98%
    SHR-2042 is a selective agonist of the GLP-1 receptor.SHR-2042 improves glycemic control by activating the GLP-1 receptor, enhancing insulin secretion and inhibiting glucagon secretion. SHR-2042 combined with sodium N-(8-[2-hydroxybenzoyl] amino) caprylate (SNAC) promotes monomerization through the formation of micelles and improves oral absorption efficiency.
    SHR-2042
  • HY-P1032F
    Biotinyl-Angiotensin I (human, mouse, rat) 1815618-04-2 98%
    Biotinyl-Angiotensin I (human, mouse, rat) is biotin-labeled Angiotensin I . Angiotensin I (human, mouse, rat) is the precursor to the vasoconstrictor peptide angiotensin II, cleaved by the angiotensin-converting enzyme (ACE).
    Biotinyl-Angiotensin I (human, mouse, rat)
  • HY-P10337
    OXM-7 98%
    OXM-7 is a dual agonist of GLP-1R (EC50=0.024 nM) and GCGR (EC50=0.082 nM). OXM-7 can enhance glucose-stimulated insulin secretion and hepatic glucose output. OXM-7 lowers blood glucose levels. OXM-7 improves lipid metabolism.
    OXM-7
  • HY-P10413
    SHBG(141–161) 98%
    SHBG 141-161 is a GPRC6A receptor agonist. SHBG 141-161 mimics the action of GPRC6A endogenous agonist uncarboxylated osteocalcin by binding to GPRC6A and promoting downstream signaling to increase testosterone and insulin secretion. SHBG 141-161 also reduces the affinity of GPRC6A to GDP protein by binding to the outer cell domain of GPRC6A thus affecting the dynamics of signal transduction. SHBG 141-161 can be used to study GPRC6A in energy metabolism and endocrine regulation.
    SHBG(141–161)
  • HY-P10472
    Azaline B 134457-28-6 98%
    Azaline B is an antagonist for gonadotropin-releasing hormone (GnRH) with IC50 of 1.37 nM, Azaline B can be used in research of sex hormone-related pathological states, ovulation induction and male contraception.
    Azaline B
  • HY-P10572
    HG1 Toxin 98%
    HG1 Toxin is a peptide found in the venom of the scorpion Heterometrus fulvipes, which has the activity of inhibiting potassium channel Kv1.3. HG1 Toxin also has the activity of inhibiting trypsin (Ki=107 nM) and can be used in the study of autoimmune diseases.
    HG1 Toxin
  • HY-P10594
    Myr-Arf1(2–17) 143244-89-7 98%
    Myr-Arf1(2–17) is a sarcosinated peptide that mimics the localization and function of Arf1 protein on the cell membrane. Myr-Arf1(2–17) can be used to study the desensitization mechanism of luteinizing hormone/chorionic gonadotropin receptor (LH/CGR).
    Myr-Arf1(2–17)
  • HY-P10780
    RFRP-3 (mouse) 98%
    RFRP-3 (mouse) is a functional ortholog of avian gonadotropin inhibitory hormone (GnIH), binding to GPR147. RFRP-3 (mouse) reduces Progesterone synthesis by inhibiting FSHR and key enzymes involved in steroidogenesis (P450scc, 3β-HSD, StAR). RFRP-3 (mouse) induces Apoptosis (increase of p53). RFRP-3 (mouse) also suppresses the ERK signaling pathway. RFRP-3 (mouse) can be used for research of follicular development.
    RFRP-3 (mouse)
  • HY-P10806
    kCAL01 1364717-03-2 98%
    kCAL01 is a CAL inhibitor with a Ki value of 2.3 μM. kCAL01 is promising for research of cystic fibrosis (CF).
    kCAL01
  • HY-P10964
    Tezusomant 2802416-72-2 98%
    Tezusomant is a growth hormone receptor antagonist. Tezusomant is promising for research of diseases such as acromegaly caused by excessive growth hormone secretion.
    Tezusomant
  • HY-P11164
    PRKGGRRRRAWGRRRRRRRRRRRRRRAPRKRLTLA
    PRKGGRRRRAWGRRRRRRRRRRRRRRAPRKRLTLA is a peptide. PRKGGRRRRAWGRRRRRRRRRRRRRRAPRKRLTLA has a higher affinity for CR3 and DNA binding domain than FOXO4 and DRI. PRKGGRRRRAWGRRRRRRRRRRRRRRAPRKRLTLA can be used in the research of aging.
    PRKGGRRRRAWGRRRRRRRRRRRRRRAPRKRLTLA
Cat. No. Product Name / Synonyms Application Reactivity