2. Endocrinology

Endocrinology

Endocrinology

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Found in most species of the animal kingdom, the endocrine system consists of glands that secrete hormones, and receptors that detect and react to the hormones. In response to environmental stimuli, the endocrine system secretes hormones and uses them as chemical messengers to orchestrate physiological, developmental and reproductive changes that affect the entire body for a long period of time. In order to maintain the proper functioning of the body through its entire life cycle, the endocrine system utilizes a complex feedback mechanism to fine-tune the balance of hormones in the bloodstream. Even a slight disruption to endocrine system’s function can throw off the delicate balance of hormones in the human body and lead to an endocrine disorder, or endocrine disease, such as diabetes, adrenal insufficiency, hyper- or hypothyroidism, and polycystic ovary syndrome (PCOS).

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N15754
    3-Hydroxy-2-methylglutaric acid 54665-33-7
    3-Hydroxy-2-methylglutaric acid is a carboxylic acid metabolite. 3-Hydroxy-2-methylglutaric acid can be isolated from the flower Veronica incana L. 3-Hydroxy-2-methylglutaric acid can be used for upper respiratory tract diseases, malignant neoplasms, gastrointestinal tract and genitourinary system disorders and diabetes mellitus research.
    3-Hydroxy-2-methylglutaric acid
  • HY-N1919A
    Ajmalicine hydrochloride 4373-34-6 98%
    Ajmalicine (Raubasine) hydrochloride is a potent adrenolytic agent which preferentially blocks α1-adrenoceptor. Ajmalicine hydrochloride is an reversible but non-competitive nicotine receptor full inhibitor, with an IC50 of 72.3 μM. Ajmalicine hydrochloride also can be used as anti-hypertensive, and serpentine, with sedative activity.
    Ajmalicine hydrochloride
  • HY-N2534R
    Karanjin (Standard) 521-88-0
    Karanjin (Standard) is the analytical standard of Karanjin. This product is intended for research and analytical applications. Karanjin is an orally active furanoflavonoid which can be isolated from several Leguminosae. Karanjin exhibits evident anti-diabetic, anti-cancer, anti-inflammatory, antioxidant, anticolitis, anti-ulcer, anti-Alzheimer properties and multiple insect repellent/insecticidal, acaricide properties, suggesting the potential of Karanjin to be applied to relevant research.
    Karanjin (Standard)
  • HY-N6257R
    Cafestol (Standard) 469-83-0
    Cafestol (Standard) is the analytical standard of Cafestol. This product is intended for research and analytical applications. Cafestol is an orally active diterpenoid and an inhibitor of ERK2. Cafestol has elevated blood lipids, anti-inflammatory, anti-angiogenic and anti-diabetic activities. In addition, Cafestol induces tumor cell apoptosis and autophagy, which can be used in the study of cancer.
    Cafestol (Standard)
  • HY-N6678S
    (Rac)-Zearalanone-d6 1795020-90-4 98%
    (Rac)-Zearalanone-d6 is the racemate of Zearalanone. Zearalenone is a nonsteroidal estrogenic mycotoxin produced by Fusarium species, which colonizes several grains. Zearalenone has low acute toxicity and carcinogenicity. Due to its agonistic effect on the estrogen receptor, Zearalenone exhibits distinct estrogenic and anabolic properties in several animal species, resulting in severe effects on the reproductive system.
    (Rac)-Zearalanone-d6
  • HY-N6741R
    β-Zearalenol (Standard) 71030-11-0
    β-Zearalenol (Standard) is the analytical standard of β-Zearalenol. This product is intended for research and analytical applications. β-Zearalenol is a non-steroidal estrogenic mycotoxin synthesized by Fusarium species. β-Zearalenol potentially influences transcription and effects gene expression on translational level.
    β-Zearalenol (Standard)
  • HY-N6896R
    Isoviolanthin (Standard) 40788-84-9
    Isoviolanthin (Standard) is the analytical standard of Isoviolanthin (HY-N6896). This product is intended for research and analytical applications. Isoviolanthin is a flavonoid glycoside. Isoviolanthin can be extracted from Dendrobium officinale. Isoviolanthin has a strong affinity for binding to KDM6B, CHAC2, ESCO2, and IPO4. Isoviolanthin decreases MMP-2 and MMP-9. Isoviolanthin inhibits TGF-β/Smad and PI3K/Akt/mTOR signaling pathways. Isoviolanthin increases Fhl3 expression. Isoviolanthin has cytoprotective effects. Isoviolanthin has anticancer activity against hepatocellular carcinoma.
    Isoviolanthin (Standard)
  • HY-N7748A
    Epi-cryptoacetalide 132152-57-9 98%
    Epi-cryptoacetalide is a natural diterpenoid. Epi-cryptoacetalide reveals high affinity to ER-α and PGE2 receptor (EP2 subtype) with Ki values of 0.3 μM and 1.92 μM, respectively. Epi-cryptoacetalide has anti-endometriosis activities.
    Epi-cryptoacetalide
  • HY-N7781R
    (-)-(E)-Guggulsterone (Standard) 39025-24-6 98%
    (-)-(E) -guggulsterone (Standard) is the analytical standard for (-)-(E) -guggulsterone ((E)-Guggulsterone) (HY-N7781). (-)-(E)-Guggulsterone is an orally active natural stereoisomer of Guggulsterone (HY-107738). (-)-(E)-Guggulsterone is an antagonist for the Farnesoid X Receptor (FXR) with an IC50 of 24.06 μM and possesses potent hypolipidemic properties. (-)-(E)-Guggulsterone suppresses dengue virus (DENV) replication by upregulating antiviral interferon responses by inducing HO-1 expression via Nrf2 activation. (-)-(E)-Guggulsterone exhibits antibacterial activities against Bacillus subtilis, Staphylococcus aureus and Pseudomonas aeruginosa. (-)-(E)-Guggulsterone has cardiac protective and antioxidant activities in rats.
    (-)-(E)-Guggulsterone (Standard)
  • HY-N8593S
    Undecane-d24 164858-54-2 98%
    Undecane-d24 is the deuterium labeled Undecane (HY-N8593).Undecane is a potent cAMP agonist with anti-allergic and anti-inflammatory activities. Undecane inhibits degranulation and the secretion of histamine and TNF-α. Undecane reverses the increased levels of p38 phosphorylation, NF-κB transcriptional activity and target cytokine/chemokine genes, including thymus and activation-regulated chemokine (TARC), macrophage-derived chemokine (MDC) and interleukin-8 (IL-8). Undecane can be used for the study of skin inflammatory disorders, such as atopic dermatitis.
    Undecane-d24
  • HY-N9457R
    Norcholic acid (Standard) 60696-62-0
    Ethambutol (dihydrochloride) (Standard) is the analytical standard of Ethambutol (dihydrochloride). This product is intended for research and analytical applications. 0
    Norcholic acid (Standard)
  • HY-NP0209
    Hydrocortisone-OVA 98%
    Hydrocortisone-OVA is a conjugate of Hydrocortisone (HY-N0583) and OVA peptide. Hydrocortisone (Cortisol) is a steroid hormone or glucocorticoid secreted by the adrenal cortex.
    Hydrocortisone-OVA
  • HY-NP0234
    Human prealbumin 98%
    Human prealbumin (Human transthyretin) is a homotetrameric protein mainly synthesised by the liver and the choroid plexus. Human prealbumin transports the thyroid hormone thyroxine and the retinol-binding protein bound to retinol in plasma and cerebrospinal fluid.
    Human prealbumin
  • HY-P0009B
    Cetrorelix diacetate 130143-01-0 98%
    Cetrorelix diacetate (SB-075 diacetate) is a potent gonadotropin-releasing hormone (GnRH) receptor antagonist with an IC50 of 1.21 nM.
    Cetrorelix diacetate
  • HY-P0036A
    Octreotide dihydrochloride 1607842-55-6 98%
    Octreotide (SMS 201-995) hydrochloride is a somatostatin receptor agonist and synthetic octapeptide endogenous somatostatin analogue. Octreotide hydrochloride can bind to the somatostatin receptors which are mainly subtypes 2, 3 and 5. Octreotide hydrochloride increases Gi activity and reduces intracellular cAMP production. Octreotide hydrochloride has antitumor activity, mediates apoptosis and may also be used in disease studies in acromegaly.
    Octreotide dihydrochloride
  • HY-P0036B
    Octreotide pamoate 135467-16-2 98%
    Octreotide (SMS 201-995) pamoate is a somatostatin receptor agonist and synthetic octapeptide endogenous somatostatin analogue. Octreotide pamoate can bind to the somatostatin receptors which are mainly subtypes 2, 3 and 5. Octreotide pamoate increases Gi activity and reduces intracellular cAMP production. Octreotide pamoate has antitumor activity, mediates apoptosis and may also be used in disease studies in acromegaly.
    Octreotide pamoate
  • HY-P0053A
    Fertirelin acetate 66002-66-2 98%
    Fertirelin acetate is a GnRH and LH-RH analogue. Fertirelin acetate can be used of the study for reversing cow follicular cysts.
    Fertirelin acetate
  • HY-P0201F
    Substance P, FAM-labeled 98%
    Substance P, FAM-labeled is a FAM labeled Substance P (HY-P0201).
    Substance P, FAM-labeled
  • HY-P0206B
    Bradykinin triacetate 5979-11-3 98%
    Bradykinin triacetate is an effective endothelium-dependent vasodilator that can lower blood pressure. Bradykinin triacetate can induce contraction of bronchial and intestinal non-vascular smooth muscle, increase vascular permeability, and participate in the mechanism of pain.
    Bradykinin triacetate
  • HY-P0221B
    PACAP (1-38) free acid TFA 98%
    PACAP (1-38) free acid TFA is an endogenous neuropeptide. PACAP (1-38) free acid TFA potently stimulates antral motility and somatostatin secretion, inhibits the secretion of gastrin and stimulates the release of vasoactive intestinal polypeptide, gastrin releasing peptide and substance P. PACAP (1-38) free acid TFA also enhances N-methyl-D-aspartate receptor function and expression of brain-derived neurotrophic factor through RACK1.
    PACAP (1-38) free acid TFA
Cat. No. Product Name / Synonyms Application Reactivity