2. Endocrinology

Endocrinology

Endocrinology

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Found in most species of the animal kingdom, the endocrine system consists of glands that secrete hormones, and receptors that detect and react to the hormones. In response to environmental stimuli, the endocrine system secretes hormones and uses them as chemical messengers to orchestrate physiological, developmental and reproductive changes that affect the entire body for a long period of time. In order to maintain the proper functioning of the body through its entire life cycle, the endocrine system utilizes a complex feedback mechanism to fine-tune the balance of hormones in the bloodstream. Even a slight disruption to endocrine system’s function can throw off the delicate balance of hormones in the human body and lead to an endocrine disorder, or endocrine disease, such as diabetes, adrenal insufficiency, hyper- or hypothyroidism, and polycystic ovary syndrome (PCOS).

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-173622
    PPARγ agonist 18 98%
    PPARγ agonist 18 (Compound (I)) is a PPARγ inhibitor (KD: 3.75 μM). PPARγ agonist 18 can inhibit CDK5-mediated phosphorylation of PPARγ at Ser245. PPARγ agonist 18 can be used in insulin resistance research.
    PPARγ agonist 18
  • HY-17382R
    Metoclopramide (Standard) 364-62-5
    Metoclopramide (Standard) is the analytical standard of Metoclopramide. This product is intended for research and analytical applications. Metoclopramide is a potent antagonist of 5-HT3 and dopamine D2 receptor, with IC50s of 308 nM and 483 nM, respectively. Metoclopramide can be used for the research of nausea and vomiting, gastro-oesophageal reflux, and gastroparesis.
    Metoclopramide (Standard)
  • HY-17382S
    Metoclopramide-d3 1216522-89-2 98%
    Metoclopramide-d3 is deuterium labeled Metoclopramide. Metoclopramide is a potent antagonist of 5-HT3 and dopamine D2 receptor, with IC50s of 308 nM and 483 nM, respectively. Metoclopramide can be used for the research of nausea and vomiting, gastro-oesophageal reflux, and gastroparesis.
    Metoclopramide-d3
  • HY-17416S
    Guanfacine-d2 hydrochloride 1398065-88-7 98%
    Guanfacine-d2 (hydrochloride) is the deuterium labeled Guanfacine hydrochloride. Guanfacine hydrochloride, an anti-hypertensive agent, is a selective α2A-adrenoceptor agonist with Kd of 31 nM and displays 60-fold selectivity over α2B-adrenoceptors.
    Guanfacine-d2 hydrochloride
  • HY-17428A
    Tripelennamine 91-81-6 98%
    Tripelennamine, an ethylenediamine derivative, is a potent histamine H1-receptor antagonist. Tripelennamine lessens the allergic response of the organism caused by histamine. Tripelennamine can be used for the research of rhinitis, conjunctivitis, and allergic and anaphylactic reactions.
    Tripelennamine
  • HY-17428B
    Tripelennamine citrate 6138-56-3 98%
    Tripelennamine citrate, an ethylenediamine derivative, is a potent histamine H1-receptor antagonist. Tripelennamine citrate lessens the allergic response of the organism caused by histamine. Tripelennamine citrate can be used for the research of rhinitis, conjunctivitis, and allergic and anaphylactic reactions.
    Tripelennamine citrate
  • HY-17428R
    Tripelennamine hydrochloride (Standard) 154-69-8
    Tripelennamine (hydrochloride) (Standard) is the analytical standard of Tripelennamine (hydrochloride). This product is intended for research and analytical applications. Tripelennamine hydrochloride, an ethylenediamine derivative, is a potent histamine H1-receptor antagonist. Tripelennamine hydrochloride lessens the allergic response of the organism caused by histamine. Tripelennamine hydrochloride can be used for the research of rhinitis, conjunctivitis, and allergic and anaphylactic reactions.
    Tripelennamine hydrochloride (Standard)
  • HY-17453S
    Salmeterol-d3 xinafoate 98%
    Salmeterol-d3 (xinafoate) is the deuterium labeled Salmeterol xinafoate. Salmeterol (GR 33343X) xinafoate is a potent and selective human β2 adrenoceptor agonist. Salmeterol shows potent stimulation of cAMP accumulation in CHO cells expressing human β2, β1 and β3 adrenoceptors with pEC50s of 9.6, 6.1, and 5.9, respectively.
    Salmeterol-d3 xinafoate
  • HY-17461S
    Cortisone-13C3 2350278-95-2 98%
    Cortisone-13C3 is the 13C-labeled Cortisone. Cortisone (17-Hydroxy-11-dehydrocorticosterone), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acts as an immunosuppressant and anti-inflammatory agent. Cortisone can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations.
    Cortisone-13C3
  • HY-17462R
    Adrenosterone (Standard) 382-45-6 98.58%
    Adrenosterone (Standard) is the analytical standard of Adrenosterone. This product is intended for research and analytical applications. Adrenosterone ((+)-Adrenosterone) is a competitive hydroxysteroid (11-beta) dehydrogenase 1 (HSD11β1) inhibitor. Adrenosterone is a steroid hormone with weak androgenic effect. Adrenosterone is a dietary supplement that can decrease fat and increase muscle mass. Adrenosterone acts as a suppressor of metastatic progression of human cancer cells.
    Adrenosterone (Standard)
  • HY-17463S
    Prednisolone-d8 98%
    Prednisolone-d8 is the deuterium labeled Prednisolone. Prednisolone is a potent, orally active corticosteroid and a glucocorticoid. Prednisolone possesses about four times the anti-inflammatory activity of hydrocortisone while causing less salt and water retention. Prednisolone can be used for ocular, anti-inflammatory research.
    Prednisolone-d8
  • HY-17497S
    Acebutolol-d7 2701782-36-5 98%
    Acebutolol-d7 is a deuterium labeled Acebutolol. Acebutolol is a selective β1 adrenergic receptor antagonist used in the treatment of hypertension, angina pectoris and cardiac arrhythmias.
    Acebutolol-d7
  • HY-17498B
    Atenolol hydrochloride 51706-40-2 98%
    Atenolol hydrochloride is a cardioselective β1-adrenergic receptor blocker, with a Ki of 697 nM at β1-adrenoceptor in guine pig left ventricle membrane. Atenolol hydrochloride can be used for the research of hypertension and angina pectoris.
    Atenolol hydrochloride
  • HY-175000
    L14-8 98%
    L14-8 is a potent ferroptosis inducer. L14-8 promotes PLK1 degradation via ubiquitination, increasing TP53 phosphorylation to enhance SAT1 transcription, thereby triggering ferroptosis and cancer cell death. L14-8 can be used for the study of advanced prostate cancer.
    L14-8
  • HY-17503C
    Metoprolol fumarate 80274-67-5 98%
    Metoprolol fumarate (CGP 2175C) is an orally active, selective β1-adrenoceptor antagonist. Metoprolol fumarate shows anti-inflammation, antitumor and anti-angiogenic properties.
    Metoprolol fumarate
  • HY-175085
    17-Phenyl trinor 8-iso prostaglandin E2
    17-Phenyl trinor 8-iso prostaglandin E2 is a prostaglandin analog that reduces intraocular pressure (IOP) in both normal and glaucomatous monkey eyes. 17-Phenyl trinor 8-iso prostaglandin E2 lowers IOP primarily by increasing trabecular outflow facility.
    17-Phenyl trinor 8-iso prostaglandin E2
  • HY-175105
    17-Phenoxy trinor prostaglandin F2α isopropyl ester
    17-Phenoxy trinor prostaglandin F2α isopropyl ester is a PGF2α (HY-12956) analog. PGF2α is an orally active agonist of the PGF receptor (FP receptor). PGF2α plays a key role in labor and delivery.
    17-Phenoxy trinor prostaglandin F2α isopropyl ester
  • HY-175178
    Arrestin-3 modulator-1 1214645-87-0 98%
    Arrestin-3 modulator-1 (Compound LSH-3) is an arrestin-3 modulator. Arrestin-3 modulator-1 binds arrestin-3 at the interdomain interface. Arrestin-3 modulator-1 enhances recruitment of arrestin-3 to phosphorylation-deficient β2AR in cells with increase of FRET levels. Arrestin-3 modulator-1 can be used for congenital disorders like retinal degeneration, hyperthyroidism and obesity research.
    Arrestin-3 modulator-1
  • HY-175434
    CIMBA hydrochloride
    CIMBA hydrochloride is a selective G protein-coupled estrogen receptor (GPER) antagonist. CIMBA hydrochloride is used in the research of cholesterol gallstones in women.
    CIMBA hydrochloride
  • HY-175669
    ANO1-IN-5 98%
    ANO1-IN-5 is an orally active ANO1 inhibitor with an IC50 of 4.57 μM. J ANO1-IN-5 demonstrates 118-, 642-, and 10000-fold selectivity over α1A-,α1B-, andα1D-AR, respectively. ANO1-IN-5 exhibits significant inhibitory effects on osteoclast differentiation and function. ANO1-IN-5 can used for the study of osteoporosis.
    ANO1-IN-5
Cat. No. Product Name / Synonyms Application Reactivity