2. Natural Products
  3. Plants
  4. Menispermaceae
  5. Stephania venosa

Stephania venosa

Stephania venosa (2):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N2255
    Crebanine 25127-29-1 99.83%
    Crebanine is an isoquinoline-like alkaloid that can be derived from Stephania. Crebanine is an antagonist of the α7-nAChR with an IC50 of 19.1 μM. Crebanine suppresses the proliferation, migration, and invasion of cancer cells, triggers reactive oxygen species (ROS) burst, and promotes apoptosis. Crebanine inhibits the AKT/FoxO3a, NF-κB and MAPK signaling pathways. Crebanine attenuates NOX2 hyperactivation, exhibits antioxidant properties by reducing reactive oxygen species and peroxidation. Crebanine inhibits voltage-dependent Na+ current in guinea-pig ventricular myocytes. Crebanine has high inhibitory activity against gram-positive animal pathogenic bacteria. Crebanine ameliorates ischemia-reperfusion brain damage in middle cerebral artery occlusion and reperfusion (MCAO/R) rats. Crebanine significantly improves Scopolamine (HY-N0296)-induced cognitive deficits in ICR mice. Crebanine can be used for the study of hepatocellular carcinoma (HCC), cerebral ischemia and Alzheimer's disease.
    Crebanine
  • HY-N3709
    Dehydrocrebanine 77784-22-6
    Dehydrocrebanine is an alkaloid that can be isolated from the tuber and leaves of Stephania venosa. Dehydrocrebanine has in vitro anti-cancer activity.
    Dehydrocrebanine