2. Peptides
  3. Peptide and Derivatives
  4. Inhibitors and Substrates
  5. β4-TAT

β4-TAT is a kind of β-sheet peptide foldamer. β4-TAT is composed of two parts: the β4 sequence (derived from the β-sheet fragment of the RRM domain of fused in sarcoma (FUS)) and the TAT sequence (a nuclear localization signal peptide that helps the entire peptide penetrate the nuclear membrane). β4-TAT influences FUS aggregation by targeting its RNA recognition motifs (RRM). β4-TAT effectively induces FUS aggregation within cells, leading to the death of cancer cells. β4-TAT can be used for the study of FUS.

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β4-TAT

β4-TAT Chemical Structure

CAS No. : 2780353-11-7

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β4-TAT Related Antibodies

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Description

β4-TAT is a kind of β-sheet peptide foldamer. β4-TAT is composed of two parts: the β4 sequence (derived from the β-sheet fragment of the RRM domain of fused in sarcoma (FUS)) and the TAT sequence (a nuclear localization signal peptide that helps the entire peptide penetrate the nuclear membrane). β4-TAT influences FUS aggregation by targeting its RNA recognition motifs (RRM). β4-TAT effectively induces FUS aggregation within cells, leading to the death of cancer cells. β4-TAT can be used for the study of FUS[1].

Molecular Weight

2205.62

Formula

C96H169N39O21
CAS No.
Sequence

Ile-Lys-Val-Ser-Phe-Ala-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg
Sequence Shortening

IKVSFAYGRKKRRQRRR
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Purity & Documentation
References
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β4-TAT Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

β4-TAT2780353-11-7FUS(364-369)-TATOthersFUS proteinβ4-TAT peptidehomologous targetingpeptide self-assemblyprotein aggregationcancer therapyRNA recognition motif (RRM)nuclear localization signal (TAT)Inhibitorinhibitorinhibit

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