β-Glu-PAB(CH2NH2)-Exatecan

Cat. No.: HY-173703 Purity: 96.60%: Data Sheet
COA

SDS
Handling Instructions
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β-Glu-PAB(CH2NH2)-Exatecan (Compound 9a) is a topoisomerase I inhibitor. β-Glu-PAB(CH2NH2)-Exatecan binds to the topoisomerase I-DNA complex to prevent DNA strand reconnection, thereby inducing DNA breakage and cell apoptosis. β-Glu-PAB(CH2NH2)-Exatecan can be specifically cleaved by β-glucuronidase highly expressed in the tumor microenvironment to release Exatecan for cytotoxic effect. β-Glu-PAB(CH2NH2)-Exatecan is also an intermediate of Mal((3S,3aR,6S,6aR) -hexahydrofuro [3, 2-B]furan-3,6-diamine-PEG12)-β -Glu-Pab-Exatecan. β-Glu-PAB(CH2NH2)-Exatecan is promising for research of cancers.

For research use only. We do not sell to patients.

β-Glu-PAB(CH2NH2)-Exatecan Chemical Structure

CAS No. : 3025108-11-3

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Topoisomerase Topo I Topo II

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

Topoisomerase

Molecular Weight

790.74

Formula

C₃₉H₃₉FN₄O₁₃

CAS No.

3025108-11-3

Appearance

Solid

Color

Off-white to light yellow

SMILES

NCC(C=C1COC(N[C@@H]2C3=C4C(C(N5C4)=CC([C@](O)(C(OC6)=O)CC)=C6C5=O)=NC7=CC(F)=C(C)C(CC2)=C73)=O)=C(C=C1)O[C@@H]8O[C@@H]([C@H]([C@@H]([C@H]8O)O)O)C(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (126.46 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.2646 mL	6.3232 mL	12.6464 mL
5 mM	0.2529 mL	1.2646 mL	2.5293 mL
10 mM	0.1265 mL	0.6323 mL	1.2646 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 96.60%

Select Batch:

Data Sheet (279 KB) SDS (252 KB)

COA (262 KB) HNMR (418 KB) RP-HPLC (294 KB) MS (71 KB)

Handling Instructions (2659 KB)

References

[1]. krishna BAJJURI, et al. β-GLUCURONIDE LINKER-PAYLOADS, PROTEIN CONJUGATES THEREOF, AND METHODS THEREOF. WO2024006272A1. 2024-09-26.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.2646 mL	6.3232 mL	12.6464 mL	31.6160 mL
	5 mM	0.2529 mL	1.2646 mL	2.5293 mL	6.3232 mL
	10 mM	0.1265 mL	0.6323 mL	1.2646 mL	3.1616 mL
	15 mM	0.0843 mL	0.4215 mL	0.8431 mL	2.1077 mL
	20 mM	0.0632 mL	0.3162 mL	0.6323 mL	1.5808 mL
	25 mM	0.0506 mL	0.2529 mL	0.5059 mL	1.2646 mL
	30 mM	0.0422 mL	0.2108 mL	0.4215 mL	1.0539 mL
	40 mM	0.0316 mL	0.1581 mL	0.3162 mL	0.7904 mL
	50 mM	0.0253 mL	0.1265 mL	0.2529 mL	0.6323 mL
	60 mM	0.0211 mL	0.1054 mL	0.2108 mL	0.5269 mL
	80 mM	0.0158 mL	0.0790 mL	0.1581 mL	0.3952 mL
	100 mM	0.0126 mL	0.0632 mL	0.1265 mL	0.3162 mL