2. Cell Cycle/DNA Damage Apoptosis
  3. CDK c-Myc Apoptosis Bcl-2 Family
  4. YX0798

YX0798 is a selective and orally active CDK9 inhibitor (Kd: 0.28 nM). YX0798 downregulates the oncoprotein c-MYC and pro-survival protein MCL-1. YX0798 disrupts the cell cycle and results in transcriptomic reprogramming, eventually leading to cell apoptosis. YX0798 has antitumor activity.

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YX0798 Chemical Structure

YX0798 Chemical Structure

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YX0798 Related Antibodies

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Description

YX0798 is a selective and orally active CDK9 inhibitor (Kd: 0.28 nM). YX0798 downregulates the oncoprotein c-MYC and pro-survival protein MCL-1. YX0798 disrupts the cell cycle and results in transcriptomic reprogramming, eventually leading to cell apoptosis. YX0798 has antitumor activity[1].

IC50 & Target[1]

CDK9

0.28 nM (Kd)

Mcl-1

 

Molecular Weight

465.86

Formula

C21H19ClF3N5O2
SMILES

O=C([C@H]1CCC[C@H](C1)NC(C(F)(F)F)=O)NC2=NC=C(C(C3=CC=NC4=C3C=CN4)=C2)Cl
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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YX0798 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

YX0798YX 0798YX-0798CDKc-MycApoptosisBcl-2 FamilyCyclin dependent kinaseMycantitumorMCLCDK9iInhibitorinhibitorinhibit

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